Chrysin-induced sperm parameters and fatty acid profile changes improve reproductive performance of roosters

Al-Tawash, Ali Sami Amin; Shahneh, Ahmad Zare; Moravej, Hossein; Ansari, M H Khadem

doi:10.1016/j.theriogenology.2017.07.022

Cited by 30 publications

(16 citation statements)

References 52 publications

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“…In contrast, in our study, male and female gerbils supplemented with 50 mg/kg/day of chrysin did not show a significant increase in testosterone levels at any of the analysed time points (3, 7, and 21 days). A recent study by Altawash and coworkers demonstrated that roosters treated for 12 consecutive weeks with chrysin at 25, 50 and 75 mg/kg/day showed an increase in serum testosterone levels only at 75 mg/kg/day . Thus, we believe that the chrysin dose employed in our study, as well as the short exposure times, was not sufficient to promote testosterone‐boosting responses in male and female gerbils.…”

Section: Discussionmentioning

confidence: 55%

Short‐term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils

Campos

Silva

Lima

et al. 2019

Int J Experimental Path

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Summary Chrysin (5,7‐dihydroxyflavone) is a bioactive compound found in different fruits, vegetables, honey and propolis. This flavone has been suggested for the treatment of reproductive dysfunction, mainly because of its antioxidant and hormonal properties. However, the effects of this polyphenol on the prostate are still poorly understood. The purpose of this study was to evaluate the effects of short‐term chrysin exposure on the ventral male and female prostates of adult gerbils. To evaluate the androgenic potential of chrysin, gerbils were also exposed to testosterone. Male and female gerbils were exposed to chrysin (50 mg/kg/day, orally) or testosterone cypionate (1 mg/kg/week, subcutaneously) for 3, 7 and 21 days. Prostates were dissected for morphological, stereological and immunohistochemical analyses. Serum levels of testosterone and 17β‐estradiol were measured by ELISA. Serum testosterone levels were not increased by chrysin supplementation in males or females. However, only females treated with chrysin for 21 days showed an increase in estradiol levels. Increased androgen receptor immunoreactivity, higher proliferation rates and glandular hyperplasia were observed in male and female prostates for all chrysin treatment times. Additionally, increased oestrogen receptor alpha immunoreactivity was observed in all chrysin‐treated females. Although chrysin and testosterone promoted similar morphological changes in the gerbil prostate, chrysin supplementation was less deleterious to prostate health, since it resulted in lower incidence of hyperplasia and an absence of neoplastic foci.

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Section: Discussionmentioning

confidence: 55%

Short‐term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils

Campos

Silva

Lima

et al. 2019

Int J Experimental Path

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show abstract

“…Studies demonstrated an increase in serum testosterone levels when rodents were exposed to chrysin doses ranging between 25 and 80 mg/ kg/day [3,6,26]. Still, in a recent study, roosters supplemented with chrysin (25, 50 or 75 mg/kg/day) during 12 weeks showed a testosterone increase only when exposed to the higher dosage (75 mg/kg) [27]. Thus, we hypothesized that the chrysin dose employed in this study (25 mg/kg/day) was not sufficient to cause testosterone boosting and consequent prostate development in male and female pubertal gerbils.…”

Section: Discussionmentioning

confidence: 92%

“…Since the bioavailability of chrysin from plant foods is low, the intake of flavonoid-rich supplements has grown greatly in recent years, mainly due to its anticancer, antioxidant and anti-inflammatory properties [4,10]. However, many studies suggest that excessive chrysin intake can be harmful to health, particularly in specific populations, such as pregnant women, newborns and patients with hormone-dependent tumors, since chrysin can interfere with biological responses evoked by estrogens [1,27]. In rodents, postnatal development and maturation of the prostate extends to the end of puberty end (~3 months old) [34].…”

Section: Discussionmentioning

confidence: 99%

Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils

et al. 2018

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Chrysin is a plant-derived polyphenol that has the potential to increase endogenous testosterone levels both by inhibiting the aromatase enzyme and by stimulating testicular steroidogenesis. The effects of chrysin on the prostate are unknown, especially during its development and functional maturation. Thus, the aim of this study was to evaluate the effects of chrysin prepubertal exposure on the male and female prostates of both pubertal and adult gerbils. To evaluate the possible androgenic responses of chrysin, gerbils were also exposed to testosterone. Male and female gerbils were exposed to chrysin or to testosterone cypionate from postnatal day 15 to 42. Male and female gerbils were euthanized at either 43days or 90days age. The prostates were collected for biometrical, morphological and immunohistochemical analysis. The results showed that prepubertal exposure to chrysin had differential effects on the prostate of both pubertal and adult animals. The prostates of male and female pubertal gerbils showed no histological alterations, although there was increased frequency of androgen receptor (AR) in males and females, and estrogen receptor alpha (ERα) in females. Adult males and females presented developed prostate glands, with higher cell proliferative rate. In addition, AR and ERα frequency remained high in the prostate of adult animals. These results demonstrated that prepubertal exposure to chrysin disrupts steroid receptors regulation in the prostate, potentiating the response of this gland to the biological effects of endogenous steroids. In this context, excessive consumption of phytoestrogens during the critical stages of development should be considered with caution.

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“…In contrast, testosterone is metabolized to estradiol by aromatase [148]. Chrysin increased testosterone levels by inhibiting aromatase activity [71]. Although detailed mechanistic studies and clinical trials are required to validate the findings, the effects of these foods on testosterone provide potential therapeutic options.…”

Section: Discussionmentioning

confidence: 99%

“…Chrysin is a flavonoid extracted from Passiflora coerulea or honeycombs. Altawash et al reported that chrysin increased testosterone in roosters by inhibiting aromatase activity [71]. However, chrysin affects thyroid function [72].…”

Section: Chrysinmentioning

confidence: 99%

A Review of foods and food supplements increasing testosterone levels

Kataoka¹,

Hotta²,

Kimura³

2021

JOMH

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Androgens are essential for male physical activity. Age-related androgen deﬁciency, known as late-onset hypogonadism (LOH), is considered a risk factor for several diseases. There are many men's health supplements on the market. Therefore, the purpose of this review is to summarize the food ingredients that have been suggested in published literature to increase testosterone levels. A review of previously reported animal studies suggested that 5 representative nutritional components, 7 food ingredients, and 25 supplements were associated with testosterone. Some food and supplements inﬂuence testosterone levels in various animals by directly increasing testosterone or suppressing the decrease in testosterone production due to testicular toxicity. There are three mechanisms by which foods or supplements increase testosterone production: 1) regulating luteinizing hormone, the hormone that stimulates testosterone production, 2) regulating testosterone synthase in the testis, and 3) regulating testosterone-degrading enzymes. In contrast, suppressing the decrease in testosterone depends on the antioxidant effect of the foods. Although detailed mechanistic studies and clinical trials are required to validate these ﬁndings, the use of food to regulate testosterone levels is a promising therapeutic option.

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Chrysin-induced sperm parameters and fatty acid profile changes improve reproductive performance of roosters

Cited by 30 publications

References 52 publications

Short‐term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils

Short‐term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils

Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils

A Review of foods and food supplements increasing testosterone levels

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