Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats

Tubuloside A, a phenylethanoid glycoside, alleviates diclofenac induced hepato‐nephro oxidative injury via Nrf2/HO‐1

“…These results indicate oxidative damage that leads to an increase in lipid peroxidation and a decrease in antioxidant enzyme activities due to the drug's toxicity. In line with the results of our study, some studies have shown that DF treatment in rats increases lipid peroxidation and reduces the effectiveness of antioxidants 37–39 . However, the significant decrease in MDA and increase in GSH levels and SOD and CAT activities observed with TA treatment demonstrate its regulatory effects against oxidative damage by reducing free radical production.…”

“…In line with the results of our study, some studies have shown that DF treatment in rats increases lipid peroxidation and reduces the effectiveness of antioxidants. [37][38][39] However, the significant decrease in MDA and increase in GSH levels and SOD and CAT activities observed with TA treatment demonstrate its regulatory effects against oxidative damage by reducing free radical production. This is consistent with previous reports of the ability of TA, a phenylethanoid compound, to improve tissue antioxidant status in rats exposed to drugs.…”

“…Here, DF induces an inflammatory response by activating the NF ‐ κB pathway and then increasing the release of inflammatory mediators. In this context, it has been revealed that DF treatment causes an increase in the levels of NF ‐ κB , 46 IL ‐ 1β 37 and TNF ‐ α , 47 which are effective in inflammation, and the levels of Cas ‐ 3 and Bax , which are effective in the apoptotic process, while causing a decrease in the expression of the anti‐apoptotic gene Bcl ‐ 2 39 and Cox ‐ 2 expression 48 in the liver and kidney tissues of rats. On the other hand, TA supplementation has prevented increased inflammation and apoptosis with DF on the Nrf2 / HO ‐ 1 signal.…”

Downregulation of inflammatory erectile dysfunction by Mantisa religiosa egg-cake through NO-cGMP-PKG dependent NF-kB signaling cascade activated by mixture of salt intake

“…Also, a pleiotropic transcription factor called NF-kB plays important roles in the immune system. Members of the NF-kB family regulate the transcriptional activity of several cell surface receptors, transcription factors, adhesion molecules, and promoters of pro-inflammatory cytokines that are implicated in inflammation [50] , [51] , [52] . Our finding shows that sub-acute exposure (14 days) of rats to NaCl only, MSG only and NaCl + MSG up-regulated the penile NF-kB molecule, reflecting endothelial dysfunction that contributes to erectile dysfunction [53] .…”

Investigation of Some Metabolic Enzyme Activities in Samples of Serum and Humor Aqueous of Cataract Cases with Pseudoexfoliation Syndrome

“…Overproduction of ROS damages cells by causing OS in them. As a result, cells have antioxidant defense systems to counteract excess ROS and maintain redox balance, both of which are essential for cell survival [38][39][40]. Several active oxidative agents are known to exist in aqueous humor, such as superoxide anions and hydrogen peroxide [41].…”