Chrysin protects against behavioral, cognitive and neurochemical alterations in a 6-hydroxydopamine model of Parkinson's disease

Fabbro, Lucian Del; Góes, André Rossito; Jessé, Cristiano Ricardo; Gomes, Marcelo Gomes de; Souza, Leandro Cattelan; Ladd, Fernando Vagner Lobo; Ladd, Aliny Antunes Barbosa Lobo; Arantes, Ricardo Vinicius Nunes; Simionato, Astor Reis; Oliveira, Mauro Schneider; Furian, Ana Flávia; Boeira, Silvana Peterini

doi:10.1016/j.neulet.2019.05.036

Cited by 47 publications

(30 citation statements)

References 25 publications

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“…In the MPTPinduced PD mouse model, chrysin pretreatment diminished oxidative stress as evaluated by lipid peroxidation levels; the pretreatment also inhibited reduction of SOD activity and GSH content in the SN region [153]. In agreement with these results, chrysin administration inhibited the increase of NO and NADPH oxidase activity and prevented the reduction of GSH in the ST of 6-OHDA-treated mice [154]. Additionally, chrysin treatment attenuated 6-OHDA-induced decreases in the levels of Na + and K + -ATPase in the ST of mice.…”

Section: Neuroprotective Roles Of Phytochemicalssupporting

confidence: 78%

“…Several neurotoxin-induced in vivo experiments also demonstrated that chrysin increased DA, 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) levels [153,154]. Moreover, chrysin administration very significantly attenuated the cognitive dysfunction and motor impairment in these animals as evaluated by passive avoidance, rotational behavior, and Barnes maze tests [154], as well as beam walk and horizontal and vertical grid tests [153]. Therefore, chrysin presents as a potential diseasemodifying agent that may also prove beneficial for symptom relief in PD.…”

Section: Neuroprotective Roles Of Phytochemicalsmentioning

confidence: 99%

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Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson’s Disease: Current Knowledge and Future Perspectives

Balakrishnan

Azam

Cho

et al. 2021

Oxidative Medicine and Cellular Longevity

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Parkinson’s disease (PD) is the second-most common neurodegenerative chronic disease affecting both cognitive performance and motor functions in aged people. Yet despite the prevalence of this disease, the current therapeutic options for the management of PD can only alleviate motor symptoms. Research has explored novel substances for naturally derived antioxidant phytochemicals with potential therapeutic benefits for PD patients through their neuroprotective mechanism, targeting oxidative stress, neuroinflammation, abnormal protein accumulation, mitochondrial dysfunction, endoplasmic reticulum stress, neurotrophic factor deficit, and apoptosis. The aim of the present study is to perform a comprehensive evaluation of naturally derived antioxidant phytochemicals with neuroprotective or therapeutic activities in PD, focusing on their neuropharmacological mechanisms, including modulation of antioxidant and anti-inflammatory activity, growth factor induction, neurotransmitter activity, direct regulation of mitochondrial apoptotic machinery, prevention of protein aggregation via modulation of protein folding, modification of cell signaling pathways, enhanced systemic immunity, autophagy, and proteasome activity. In addition, we provide data showing the relationship between nuclear factor E2-related factor 2 (Nrf2) and PD is supported by studies demonstrating that antiparkinsonian phytochemicals can activate the Nrf2/antioxidant response element (ARE) signaling pathway and Nrf2-dependent protein expression, preventing cellular oxidative damage and PD. Furthermore, we explore several experimental models that evaluated the potential neuroprotective efficacy of antioxidant phytochemical derivatives for their inhibitory effects on oxidative stress and neuroinflammation in the brain. Finally, we highlight recent developments in the nanodelivery of antioxidant phytochemicals and its neuroprotective application against pathological conditions associated with oxidative stress. In conclusion, naturally derived antioxidant phytochemicals can be considered as future pharmaceutical drug candidates to potentially alleviate symptoms or slow the progression of PD. However, further well-designed clinical studies are required to evaluate the protective and therapeutic benefits of phytochemicals as promising drugs in the management of PD.

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Section: Neuroprotective Roles Of Phytochemicalssupporting

confidence: 78%

Section: Neuroprotective Roles Of Phytochemicalsmentioning

confidence: 99%

Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson’s Disease: Current Knowledge and Future Perspectives

Balakrishnan

Azam

Cho

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Over the last decades, the antioxidant effects of different types of flavonoids have been reported. Moreover, it has been studied whether flavonoids contribute to the neuroprotection and the improvement of locomotor activity through the anti-oxidative effect of them, due to the DA neurons having vulnerability for oxidative stress [ 179 , 221 ]. As mentioned above, flavonoids induce protective effects against neurodegeneration in models of PD in vivo and in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…Flavones: Chrysin, baicalein, apigenin, and luteolin are representative flavones. They suppress diverse neurotoxic events, such as neuroinflammation, abnormal apoptosis, and OS, through activation of ERK1/2, PI3K/Akt, and GSK-3β signaling pathways and upregulation of gene expression related to the anti-oxidative defense system ( Table 3 ) [ 178 , 179 , 180 , 181 , 182 , 183 , 184 ].…”

Section: Natural Antioxidants: Flavonoidsmentioning

confidence: 99%

Control of Reactive Oxygen Species for the Prevention of Parkinson’s Disease: The Possible Application of Flavonoids

et al. 2020

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Oxidative stress reflects an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense systems, and it can be associated with the pathogenesis and progression of neurodegenerative diseases such as multiple sclerosis, stroke, and Parkinson’s disease (PD). The application of antioxidants, which can defend against oxidative stress, is able to detoxify the reactive intermediates and prevent neurodegeneration resulting from excessive ROS production. There are many reports showing that numerous flavonoids, a large group of natural phenolic compounds, can act as antioxidants and the application of flavonoids has beneficial effects in the adult brain. For instance, it is well known that the long-term consumption of the green tea-derived flavonoids catechin and epigallocatechin gallate (EGCG) can attenuate the onset of PD. Also, flavonoids such as ampelopsin and pinocembrin can inhibit mitochondrial dysfunction and neuronal death through the regulation of gene expression of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Additionally, it is well established that many flavonoids exhibit anti-apoptosis and anti-inflammatory effects through cellular signaling pathways, such as those involving (ERK), glycogen synthase kinase-3β (GSK-3β), and (Akt), resulting in neuroprotection. In this review article, we have described the oxidative stress involved in PD and explained the therapeutic potential of flavonoids to protect the nigrostriatal DA system, which may be useful to prevent PD.

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“…The biosynthesis of dopamine starts with tyrosine hydroxylation by tyrosine hydroxylase, and via several reactions, it gets synthesized and stored inside the synaptic vesicles of dopaminergic neurons [64]. Chrysin was shown to reduce dopamine depletion and protect against the neurodegeneration of dopaminergic neurons of the brain [61,65]. It was also observed that chrysin treatment can significantly induce dopamine level recovery in the hippocampus and the prefrontal cortex region of the brain [66].…”

Section: Chrysin As a Mao Inhibitormentioning

confidence: 99%

Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders

Mishra

Bandopadhyay

et al. 2021

Molecules

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Chrysin, a herbal bioactive molecule, exerts a plethora of pharmacological effects, including anti-oxidant, anti-inflammatory, neuroprotective, and anti-cancer. A growing body of evidence has highlighted the emerging role of chrysin in a variety of neurological disorders, including Alzheimer’s and Parkinson’s disease, epilepsy, multiple sclerosis, ischemic stroke, traumatic brain injury, and brain tumors. Based on the results of recent pre-clinical studies and evidence from studies in humans, this review is focused on the molecular mechanisms underlying the neuroprotective effects of chrysin in different neurological diseases. In addition, the potential challenges, and opportunities of chrysin’s inclusion in the neurotherapeutics repertoire are critically discussed.

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Chrysin protects against behavioral, cognitive and neurochemical alterations in a 6-hydroxydopamine model of Parkinson's disease

Cited by 47 publications

References 25 publications

Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson’s Disease: Current Knowledge and Future Perspectives

Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson’s Disease: Current Knowledge and Future Perspectives

Control of Reactive Oxygen Species for the Prevention of Parkinson’s Disease: The Possible Application of Flavonoids

Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders

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