Chrysin suppresses lipopolysaccharide‐induced cyclooxygenase‐2 expression through the inhibition of nuclear factor for IL‐6 (NF‐IL6) DNA‐binding activity

Woo, Kyung Jin; Jeong, Yong-Jin; Inoue, H.; Park, Jong‐Wook; Kwon, Taeg Kyu

doi:10.1016/j.febslet.2004.12.048

Cited by 136 publications

(80 citation statements)

References 39 publications

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“…We also found that a 4-week intake of resveratrol led to upregulation of hepatic expression of SIRT1 in wild type, but not PPARα knockout mice (submitted). Polyphenolic compounds such as apigenin, chrysin (Liang et al, 1999;Woo et al, 2005), and humulon (Yamamoto et al, 2000) suppress COX-2 expression and activate PPARα and/or γ (Liang et al, 2001;Yajima et al, 2004). These findings suggest that various food-derived components have effects on PPARs and COX-2 that are comparable to those of resveratrol.…”

Section: Citral a Component Of Lemongrass Oilsupporting

confidence: 51%

Evaluation of Food-derived Functional Ingredients According to Activation of PPAR and Suppression of COX-2 Expression

Nakata

Takizawa

Takai

et al. 2013

FSTR

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The peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors belonging to the nuclear receptor family. They are considered molecular targets for the prevention of lifestyle-related diseases and are involved in the control of cyclooxygenase (COX)-2 expression. COX-2, the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis, and its expression is partly controlled by PPAR. We have identified several natural chemicals, such as resveratrol, that activate PPARs and suppress COX-2 expression. In this review, we provide an evaluation of food-derived functional ingredients that target PPARs and COX-2.Keywords: PPAR, COX-2, resveratrol, essential oil, anti-lifestyle-related disease *To whom correspondence should be addressed. E-mail: inoue@cc.nara-wu.ac.jp IntroductionThe prevention of lifestyle-related diseases, such as cardiovascular disease, diabetes, and stroke, is of worldwide interest. Individuals tend to focus not only on drug therapy for prevention of these diseases, but also on the functionality of natural chemicals found in food and beverages, such as polyphenols and their polymers. A growing body of evidence supports the theory that polyphenolic compounds have activities that maintain health. Epidemiological studies have demonstrated that dietary polyphenol intake, e.g., red wine consumption, may improve endothelial function and reduce risk for cardiovascular diseases (Stoclet et al., 2004; Cordova et al., 2005;Opie et al., 2007). Although there have been numerous studies investigating food-derived functional components, the molecular mechanisms for their actions remain to be determined. We found that several natural food-derived components, such as resveratrol, activate peroxisome proliferator-activated receptors (PPARs) and suppress expression of cyclooxygenase (COX)-2. These two properties targeted specifically to PPARs and COX-2 will be important for evaluating food-derived functional components. This review discusses the effects of food-derived functional components on PPARs and COX-2, and evaluates novel functions of these compounds in relation to prevention of lifestyle-related diseases. Linkage Between PPAR and COX-2PPARs are members of a nuclear receptor family of ligand-dependent transcription factors (Mangelsdolf et al., 1995). The PPAR subfamily comprises three isotypes, PPARα, β/δ and γ, which play various roles in lipid and carbohydrate metabolism, cell proliferation and differentiation, and inflammation; they are considered molecular targets in the prevention of lifestyle-related diseases (Michalik et al., 2006;Sonoda et al., 2008). For example, PPARα agonists, such as fibrates and thiazolidine derivatives, are used to treat dyslipidemia and diabetes, respectively. Moreover, eicosapentaenoic acid, a natural ligand for PPARα, has been used as a hypolipidemic drug and has been reported to lower plasma and liver cholesterol levels in a PPARα-dependent manner (Sugiyama et al., 2008).PPARs are also invo...

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Section: Citral a Component Of Lemongrass Oilsupporting

confidence: 51%

Evaluation of Food-derived Functional Ingredients According to Activation of PPAR and Suppression of COX-2 Expression

Nakata

Takizawa

Takai

et al. 2013

FSTR

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“…Caffeic acid also presents immunosuppressive activity, inhibiting the early and late events of T cell activation and the consequent release of cytokines such as IL-2 (Marquez et al, 2004) in an unspecific way of inhibition of ion channels (Nam et al, 2009). Chrysin, a flavonoid isolated from propolis, also seems to suppress the expression of COX-2 by inhibiting a nuclear factor for IL-6 (Woo et al, 2005).…”

Section: Anti-inflammatory and Immunomodulatory Response To Isolated mentioning

confidence: 99%

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Araújo

Libério

Guerra

et al. 2012

Rev. bras. farmacogn.

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Many biological properties have been attributed to various types of propolis, including anti-inflammatory, antimicrobial, antioxidant, antitumor, wound healing, and immunomodulatory activities. This article reviewed studies published that investigated the anti-inflammatory activity of propolis of different origins and/ or its isolated components, focusing on the mechanisms of action underlying this activity and also addressing some aspects of immunomodulatory effects. The search was performed of the following databases: PubMed, Science Direct, HighWire Press, Scielo, Google Academics, Research Gate and ISI Web of Knowledgement. The anti-inflammatory activity was associated with propolis or compounds such as polyphenols (flavonoids, phenolic acids and their esters), terpenoids, steroids and amino acids. CAPE is the most studied compounds. The main mechanisms underlying the anti-inflammatory activity of propolis included the inhibition of cyclooxygenase and consequent inhibition of prostaglandin biosynthesis, free radical scavenging, inhibition of nitric oxide synthesis, reduction in the concentration of inflammatory cytokines and immunosuppressive activity. Propolis was found to exert an antiinflammatory activity in vivo and in vitro models of acute and chronic inflammation and others studies, indicating its promising potential as anti-inflammatory agent of natural origin and as a source of chemical compounds for the development of new drugs.

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“…42) Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro (5 μM) and in vivo (0.04% of diet for 8 weeks), but has no effect on SIRT1 activation. 32) Polyphenolic compounds such as apigenin, chrysin, 43,44) and humulon 45) ( Fig. 1) suppress COX-2 expression and also activate PPARα and/or γ.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Study on Resveratrol

Nakata

Takahashi

Inoue

2012

Biological & Pharmaceutical Bulletin

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152

112

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Appropriate long-term drinking of red wine is associated with a reduced risk for lifestyle-related diseases such as cardiovascular disease and cancer, making resveratrol, a constituent of grapes and various other plants, an attractive compound to be studied. Historically, resveratrol has been identified as a phytoalexin, antioxidant, cyclooxygenase (COX) inhibitor, peroxisome proliferator-activated receptor (PPAR) activator, endothelial nitric oxide synthase (eNOS) inducer, silent mating type information regulation 2 homolog 1 (SIRT1) activator, and more. Despite scepticism concerning the biological availability of resveratrol, a growing body of in vivo evidence indicates that resveratrol has protective effects in several stress and disease models. Here, we provide a review of the studies on resveratrol, especially with respect to COX, PPAR, and eNOS activities, and discuss its potential for promoting human health.

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Chrysin suppresses lipopolysaccharide‐induced cyclooxygenase‐2 expression through the inhibition of nuclear factor for IL‐6 (NF‐IL6) DNA‐binding activity

Cited by 136 publications

References 39 publications

Evaluation of Food-derived Functional Ingredients According to Activation of PPAR and Suppression of COX-2 Expression

Evaluation of Food-derived Functional Ingredients According to Activation of PPAR and Suppression of COX-2 Expression

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Recent Advances in the Study on Resveratrol

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