Chrysoeriol ameliorates TPA-induced acute skin inflammation in mice and inhibits NF-κB and STAT3 pathways

Wu, Jia‐Ying; Chen, Ying‐Jie; Bai, Lu; Liu, Yuxi; Fu, Xiu‐Qiong; Zhu, Peili; Li, Jun‐Kui; Chou, Ji‐Yao; Yin, Chang-Cheng; Wang, Yaping; Bai, Jing‐Xuan; Wu, Ying; Wu, Zhengzhi; Yu, Zhi‐Ling

doi:10.1016/j.phymed.2020.153173

Cited by 66 publications

(35 citation statements)

References 34 publications

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“…491-71-4; Figure 4 A) exhibited the strongest inhibitory activity (97.0 ± 2.20%). Chrysoeriol is present in lemon, Rooibos tea, pepper, and green vegetables such as celery, and exerts antioxidant, anti-inflammatory, and antitumor effects [ 41 , 42 , 43 , 44 , 45 ]. It has been reported that chrysoeriol inhibits CYP1B1 enzyme activity responsible for hydroxylation of 17β-estradiol in MCF-7 breast cancer cells [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

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Chrysoeriol Prevents TNFα-Induced CYP19 Gene Expression via EGR-1 Downregulation in MCF7 Breast Cancer Cells

Min

Jung

Ahn

et al. 2020

IJMS

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Estrogen overproduction is closely associated with the development of estrogen receptor-positive breast cancer. Aromatase, encoded by the cytochrome P450 19 (CYP19) gene, regulates estrogen biosynthesis. This study aimed to identify active flavones that inhibit CYP19 expression and to explore the underlying mechanisms. CYP19 expression was evaluated using reverse transcription PCR, quantitative real-time PCR, and immunoblot analysis. The role of transcription factor early growth response gene 1 (EGR-1) in CYP19 expression was assessed using the short-hairpin RNA (shRNA)-mediated knockdown of EGR-1 expression in estrogen receptor-positive MCF-7 breast cancer cells. We screened 39 flavonoids containing 26 flavones and 13 flavanones using the EGR1 promoter reporter activity assay and observed that chrysoeriol exerted the highest inhibitory activity on tumor necrosis factor alpha (TNFα)-induced EGR-1 expression. We further characterized and demonstrated that chrysoeriol inhibits TNFα-induced CYP19 expression through inhibition of extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated EGR-1 expression. Chrysoeriol may be beneficial as a dietary supplement for the prevention of estrogen receptor-positive breast cancer, or as a chemotherapeutic adjuvant in the treatment of this condition.

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Section: Resultsmentioning

confidence: 99%

“…Chrysoeriol is present in several foods and vegetables [ 41 , 42 , 43 , 44 , 45 ]. Many dietary phenolics are generally poorly bioavailable, limiting their distribution in systemic tissues of their native form, mainly as glycosides and complex oligomeric structures [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Chrysoeriol Prevents TNFα-Induced CYP19 Gene Expression via EGR-1 Downregulation in MCF7 Breast Cancer Cells

Min

Jung

Ahn

et al. 2020

IJMS

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“…[56] Chrysoeriol (115) showed good anti-inflammatory effects and inhibited nuclear factor-kappa B (NF-KB) signaling. [57] Kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-Dglucopyranoside (27) showed significant inhibitory effects on inflammatory mediators such as NO and PGE2, and anti-inflammatory activities in vitro with 106.5 pg/mL. [58] 5,7,3',4',5'-Pentamethoxyflavone (43) exerted the anti-inflammatory activity with an IC50 value of 53.40 μM.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…[72] Chrysoeriol (115), as an antioxidant, could increase the resistance of rice to the white-backed planthopper (WBPH). [57] Kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-Dgalactopyranoside (28) showed antioxidant capacity. [73] Chrysin (45), a natural flavonoid with potent antioxidant activity, showed protective activity against sodium arsenite (SA)-induced hepatotoxicity.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Flavonoids Isolated from the genus Ficus and Their Biological Activities

Zhao¹,

Niu²,

Zhou³

et al. 2021

Med. Res.

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There are about 1000 species in the genus Ficus and many can be used for medicinal purpose. The medicinal plants of this genus mainly contain terpenoids, flavonoids, alkaloids, and coumarins. In this paper, we summarized flavonoids isolated from the genus Ficus and their pharmacological effects including anti-bacterial, anti-inflammatory, antitumor, antioxidant, antiviral, protective activities on the cardiovascular system and other activities.

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“…Western blot assays were performed as described previously [19]. Immunoreactive bands were visualized using the Enhanced Chemiluminescence (ECL) detection system (Invitrogen, Carlsbad, CA, USA).…”

Section: Western Blot Analysismentioning

confidence: 99%

Twenty-four-week oral dosing toxicities of Herba Siegesbeckiae in rats

Chan

Guo

et al. 2020

BMC Complement Med Ther

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Background Herba Siegesbeckiae (HS), the dried aerial parts of Siegesbeckia orientalis L., S. pubescens Makino, or S. glabrescens Makino, is traditionally used for treating chronic diseases in China. However, there is no information about the chronic toxicity of HS. The objective of this study is to evaluate the 24-week oral dosing toxicities of HS aqueous extract (HSE) in rats. Methods S. orientalis-originated HS was reflux-extracted with distilled water. Sprague–Dawley rats were randomly divided into four groups, with 10 males and 10 females in each group. The rats were intragastrically administered with HSE at 5, 1.67 and 0.56 g/kg (experimental groups) or an equal volume of distilled water (control group), 6 days a week, for 24 weeks. The high dose of HSE (5 g/kg) was its maximum tolerated dose. Body weight was recorded every 2 days during the experimental period. Chemical, hematological and histopathological parameters, as well as organ weights, were measured at the end of the experiment. Results Decreased body weight gain; increased liver and lung relative weights; histopathological alterations in liver and lung tissues; elevated serum levels of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase were found after HSE treatments. In liver tissues, HSE treatment upregulated levels of three pro-inflammatory cytokines: IL-6, IL-1β and TNF-α. In lung tissues, HSE treatment caused oxidative stress and activated mitogen-activated protein kinases (MAPKs). Conclusion Long-term oral administration of HSE caused toxicities in rats evidenced by decreased body weight gain, as well as liver and lung damage. Treatment-induced oxidative stress, inflammation and MAPK activation are involved in HSE’s toxicities. Caution should be taken when using HS to treat chronic diseases.

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Chrysoeriol ameliorates TPA-induced acute skin inflammation in mice and inhibits NF-κB and STAT3 pathways

Cited by 66 publications

References 34 publications

Chrysoeriol Prevents TNFα-Induced CYP19 Gene Expression via EGR-1 Downregulation in MCF7 Breast Cancer Cells

Chrysoeriol Prevents TNFα-Induced CYP19 Gene Expression via EGR-1 Downregulation in MCF7 Breast Cancer Cells

Flavonoids Isolated from the genus Ficus and Their Biological Activities

Twenty-four-week oral dosing toxicities of Herba Siegesbeckiae in rats

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