Churg–Strauss syndrome complicated by central retinal artery occlusion: case report and a review of the literature

Asako, Kurumi; Takayama, Maki; Kono, Hajime; Kikuchi, Hirotoshi

doi:10.1007/s10165-011-0422-y

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…Thus far, 17 cases of EGPA presenting with CRAO have been reported (3,(5)(6)(7)(8)(9); however, no case developed vasculitis symptoms during treatment with an anti-IL-5 receptor monoclonal antibody. Improvement in visual acuity was obtained in only four cases (5)(6)(7).…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Granulomatosis with Polyangiitis Presenting with Central Retinal Artery Occlusion During Treatment with Anti-interleukin-5 Receptor Monoclonal Antibody

et al. 2021

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Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophilic cytoplasm antibody (ANCA)associated vasculitis characterized by asthma and eosinophilia. Although EGPA involves multiple organs, ocular involvement is infrequent and often carries a poor visual prognosis. We herein report a rare case of EGPA presenting with central retinal artery occlusion (CRAO) in which visual loss developed during treatment with anti-interleukin (IL)-5 receptor monoclonal antibody, and improvement in visual outcomes was attained after treatment combining high-dose oral corticosteroids, cyclophosphamide and an anticoagulant. Physicians should consider CRAO as an ophthalmic manifestation of EGPA in patients with severe eosinophilic asthma.

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Section: Discussionmentioning

confidence: 99%

Eosinophilic Granulomatosis with Polyangiitis Presenting with Central Retinal Artery Occlusion During Treatment with Anti-interleukin-5 Receptor Monoclonal Antibody

et al. 2021

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“…[ 2 , 3 ] GPA (a typical type of c-ANCA-associated vasculitis), which had been referred to as Wegener's granulomatosis, is reportedly associated with ocular complications including scleritis, orbital inflammatory pseudotumor, peripheral corneal ulcer, iritis, and ocular ischemia due to temporal arteritis; and there are also reports of concurrent onset of CRAO. [ 5 – 15 ] For MPA (a type of p-ANCA-associated vasculitis), the reported ocular complications include conjunctival lithiasis, peripheral corneal ulcer, and retinal vein occlusion. For EGPA, which had been referred to as allergic granulomatous angiitis and Churg-Strauss syndrome, uveitis, retinal artery occlusion, and other ocular complications are reported.…”

Section: Discussionmentioning

confidence: 99%

Development of central retinal artery occlusion accompanied by choroidal folds in a patient with antineutrophil cytoplasmic antibody-associated vasculitis

et al. 2020

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Rationale: We report a case of central retinal artery occlusion (CRAO) accompanied by choroidal folds in a patient positive for myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA). Patient concerns: The study involved a 67-year-old female patient who presented at the Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan on October 24, 2016 after becoming aware of a sudden decrease of visual acuity (VA) in her right eye. Other than suffering with scleritis 6-months previous, there was no obvious past history. Diagnosis: Upon examination, the VA in her right eye was hand motion, and the anterior segment of that eye showed thinning of the superior sclera. Macular edema in the inner retina and cherry red spots were observed in the ocular fundus, and optical coherence tomography (OCT) findings showed hyperreflectivity of the inner retina and choroidal folds. Fluorescein angiography (FA) examination of the fundus showed scattered areas of no retinal perfusion, and indocyanine green angiography (IA) findings of the fundus indicated a possible choroidal circulatory disturbance in her right eye. Blood test findings revealed the patient to be positive for MPO-ANCA. Based on the above findings, the patient was diagnosed with CRAO and choroidal circulatory disturbance due to ANCA-associated vasculitis. Interventions: For treatment, steroid semi-pulse therapy was initiated. Outcomes: Post treatment initiation, the fundus features and choroidal folds gradually improved, and her VA slightly improved to 0.08. Lessons: Based on the FA, IA, and OCT findings, the present case was considered to have CRAO accompanied by choroidal circulatory disturbance due to ANCA-associated vasculitis, a rare disease that may be complicated by choroidal circulatory disturbances.

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“…The clinical profiles of six reported patients with this disease with CRAO are summarized in Table (7)(8)(9)(10)(11)(12). The diagnoses include CSS in five patients and giant cell arteritis in one patient.…”

Section: Discussionmentioning

confidence: 99%

ANCA-associated Vasculitis with Central Retinal Artery Occlusion Developing during Treatment with Methimazole

et al. 2012

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A 63-year-old woman suddenly developed central retinal artery occlusion following a slight fever while being treated with methimazole (MMI) for hyperthyroidism. She was diagnosed to have anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) based on increased inflammatory reactions with positive myeloperoxidase-ANCA in the serum. Her visual acuity remained low despite immediate treatment with corticosteroids and cyclophosphamide after cessation of MMI, which may have played a role in the pathogenesis of AAV. Central retinal artery occlusion is a rare manifestation of AAV; however, it is important with regard to the possibility of serious sequelae.

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Churg–Strauss syndrome complicated by central retinal artery occlusion: case report and a review of the literature

Cited by 7 publications

References 18 publications

Eosinophilic Granulomatosis with Polyangiitis Presenting with Central Retinal Artery Occlusion During Treatment with Anti-interleukin-5 Receptor Monoclonal Antibody

Eosinophilic Granulomatosis with Polyangiitis Presenting with Central Retinal Artery Occlusion During Treatment with Anti-interleukin-5 Receptor Monoclonal Antibody

Development of central retinal artery occlusion accompanied by choroidal folds in a patient with antineutrophil cytoplasmic antibody-associated vasculitis

ANCA-associated Vasculitis with Central Retinal Artery Occlusion Developing during Treatment with Methimazole

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