Churg-Strauss syndrome that presented with mediastinal lymphadenopathy and calculous cholecystitis

Innate immune response reflects disease activity in eosinophilic granulomatosis with polyangiitis

“…Lung involvement was defined as consolidation, ground-glass opacity, nodules within a ground-glass opacity, interlobular septal thickening, 38,39 bronchial wall thickening, lymph node enlargement, 40,41 pleural effusion (identified on highresolution computed tomography 38,42 ), or eosinophilic infiltration (detected on lung biopsy). Lung involvement was defined as consolidation, ground-glass opacity, nodules within a ground-glass opacity, interlobular septal thickening, 38,39 bronchial wall thickening, lymph node enlargement, 40,41 pleural effusion (identified on highresolution computed tomography 38,42 ), or eosinophilic infiltration (detected on lung biopsy).…”

“…Sensory nerve dysfunction was assessed subjectively based on symptoms and physical examination. Lung involvement was defined as consolidation, ground-glass opacity, nodules within a ground-glass opacity, interlobular septal thickening, 38,39 bronchial wall thickening, lymph node enlargement, 40,41 pleural effusion (identified on highresolution computed tomography 38,42 ), or eosinophilic infiltration (detected on lung biopsy). Cardiac involvement was defined as cardiac symptoms (chest pain, chest discomfort, back pain, or palpitations) or abnormal signs (identified on cardiac echocardiography, Holter electrocardiogram, plasma B-type natriuretic peptide-level analysis, or myocardial imaging using 123 I-metaiodobenzylguanidine).…”

Necrotizing eosinophilic granulomatous lymphadenitis with ring- and C-shaped granulomas—an underrecognized specific manifestation of nodal Churg-Strauss syndrome

“…GPA is most commonly associated with proteinase 3 ANCAs that correlate with perinuclear and cytoplasmic immunofluorescence patterns, respectively. Nodal involvement as the main or prominent clinical manifestation of CSS/ EGPA has been recognized with increasing frequency since the early 2000's; this presentation has not been described in GPA [4,[9][10][11][12]. Most of these cases describe atypical clinical presentations, probably because in classic cases, a nodal biopsy would not be needed for diagnosis, and most have been reported in non-pathology journals, and thus the description of morphologic and immunophenotypic findings has been limited.…”

“…Most of these cases describe atypical clinical presentations, probably because in classic cases, a nodal biopsy would not be needed for diagnosis, and most have been reported in non-pathology journals, and thus the description of morphologic and immunophenotypic findings has been limited. The reported findings vary from simple lymphoid hyperplasia, plasma cell hyperplasia, hyperplasia with eosinophilia, and hyperplasia with Ballergic granulomas,^the pathognomonic finding of CSS/EGPA [9][10][11][12]. The only detailed immunomorphologic description of nodal CSS/EGPA was done in a case report by Cualing H et al [4] This group emphasized the presence of unusual ring-and C-shaped granulomas surrounding reactive follicles or eosinophilic abscesses in a reactive background.…”

Eosinophilic Granulomatosis with Polyangiitis Presented as Acute Polyneuropathy and Cerebral Vasculitis

“…EGPA can affect multiple organ systems, including the cardiac, pulmonary, renal, nervous, and vascular systems, and is characterized by asthma, fever, eosinophilia, pericarditis, pericardial effusion, myocardial infarction, acute heart failure, renal injury, and peripheral neuropathy [123456]. …”