2012
DOI: 10.2165/11596960-000000000-00000
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Cicatricial (Scarring) Alopecias

Abstract: Cicatricial (scarring) alopecia forms a group of disorders in which the common final pathway is the destruction of the hair follicle unit that is replaced by fibrous tissue. Hair loss may occur as a primary event when the follicle is the main target of the disease process (primary cicatricial alopecias) or as a secondary event when the follicle act as an 'innocent bystander' in the course of a disease occurring outside of the follicular unit (secondary cicatricial alopecias). Permanent hair loss may also occur… Show more

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Cited by 46 publications
(55 citation statements)
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“…[5] In the former, a group of rare disorders (lupus erythematosus, lichen planus, graft vs host disease, scleroderma, dermatomyositis, sarcoidosis, malignancy, etc .,) destroys the hair follicles to replace it with scar tissue and cause permanent hair loss. In non-cicatricial alopecia, the underlying cause is usually the drugs apart from androgenic alopecia.…”
Section: Discussionmentioning
confidence: 99%
“…[5] In the former, a group of rare disorders (lupus erythematosus, lichen planus, graft vs host disease, scleroderma, dermatomyositis, sarcoidosis, malignancy, etc .,) destroys the hair follicles to replace it with scar tissue and cause permanent hair loss. In non-cicatricial alopecia, the underlying cause is usually the drugs apart from androgenic alopecia.…”
Section: Discussionmentioning
confidence: 99%
“…In primary cicatricial alopecias, the hair follicle is the chief target of the disorder . A variety of hypothesis (which have overlapping features) have been postulated, but none have been definitely proven and debate still exists . An autoimmune origin is possible, especially for lymphocyte‐mediated alopecias .…”
Section: Supplementmentioning
confidence: 99%
“…An autoimmune origin is possible, especially for lymphocyte‐mediated alopecias . The bulge region with the stem cell reservoir of the follicular unit may be the target leading to the permanent hair loss . Use of anti‐inflammatory medications in scarring alopecias also leads credence to this theory, but does not explain salient points of when, where and how the immune response acts with respect to the pilosebaceous units .…”
Section: Supplementmentioning
confidence: 99%
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“…They have been classified according to the type of inflammatory cell reaction that leads to the destruction of the hair follicle (lymphocytic, neutrophilic and mixed) and its replacement by fibrous tissue. Several excellent published reviews give a detailed overview of the classification and management of the various scarring alopecias even if the literature on this topic is sparse [1,2,3]. Regardless of the type of alopecia the patient is suffering from, the importance of early diagnosis and treatment cannot be overemphasized as scarring alopecias are considered trichologic emergencies [4].…”
Section: Introductionmentioning
confidence: 99%