Cicatrização da parede abdominal após hepatectomia parcial

Biondo-Simões, Maria de Lourdes Pessole; Bonato, Flávia Thaiana; Menacho, Aline Moraes; Drechmer, Mariana; Cavalcanti, Tereza Cristina Santos; Felizola, Saulo José Alves

doi:10.1590/s0100-69912011000200011

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…In an experimental review by Biondo-Simões et al, it was shown that the procedure of hepatectomy leads to a delay of the healing process, interfering with collagen synthesis and angiogenesis, which could explain the results of incisional hernia, but not addressing type of incision [20].…”

Section: Discussionmentioning

confidence: 99%

Comparison of J-Shaped Incision and Mercedes Incision for Liver Transplantation

2015

J Surg

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Wound-related and incision-related complications such as wound infections and incisional hernias are common after liver transplantation. Advances in surgical, anesthesiological, critical care, and immunological innovations have led to a dramatic reduction in postoperative morbidity and mortality. Orthotopic liver transplant (OLT) has been first described with traditionally Mercedes type incision. Less traumatic J shaped incision has been used more frequently. We analyzed retrospectively 110 consecutive patients submitted to OLT in our institution from November 2010 to December 2012. In our program, beginning on September 2011, orthotopic liver transplantation (OLT) was performed using J-shaped (J) incision routinely, switching from a previous Mercedes (M) incision. We compared the incidence for surgical site infection (SSI), incisional hernia, and overall satisfaction. Fifty patients submitted to OLT using J-shaped incision were compared to 60 patients with M incision. Age, sex distribution, indication for OLT, and MELD score were similar in both groups. Three patients in the J group developed SSI, 6%, while 13, 21.6%, patients in the M group developed SSI (p=0.02). Incisional hernia was observed in 9 patients in the J group, 18%, compared with 22 patients in M group, 36.6% (p=0.03). Regarding overall satisfaction with the results of the incision, 48 patients, 96%, in J group gave the highest score, while in the M group, 45 patients, 75%, attributed the highest score for the questionnaire. After we have decided to switch from Mercedes type incision to J-shaped incision, OLT was feasible in all patients. When refraining to incise rectus abdominis on both sides, we provide a less traumatic incision, which leads to fewer complications postoperatively. Our results suggest that a J-shaped incision is preferred to other incisions for OLT.

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Section: Discussionmentioning

confidence: 99%

Comparison of J-Shaped Incision and Mercedes Incision for Liver Transplantation

2015

J Surg

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“…The animals were housed in the Laboratory of the Discipline of Surgical Technique and Experimental Surgery of the Federal University of Paraná, where they remained during the quarantine period and throughout the experiment. The sample size was calculated based on previous works with a similar research protocol approved by CEUA-BIO 18 , 19 .…”

Section: Methodsmentioning

confidence: 99%

Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats

Biondo-Simões

Pessini

Ichi

et al. 2021

Rev. Col. Bras. Cir.

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Objective: to evaluate the influence of acetylsalicylic acid (ASA) on cell proliferation after partial hepatectomy in rats. Methods: 40 male Wistar rats were separated into four groups of ten rats each. Groups 1 and 2 (controls): undergoing 30% partial hepatectomy and, after one day (group 1) and seven days (group 2), to euthanasia; daily administration of 0.9% saline solution (1mL per 200g of body weight). Groups 3 and 4 (experimental): undergoing 30% partial hepatectomy and, after one day (group 3) and seven days (group 4), to euthanasia; daily administration of ASA (40mg/mL, 1mL per 200g of body weight). The absolute number of cells stained with PCNA was counted in photomicrographs, in five fields, and it was calculated the mean of positive cells per animal and per group. Results: the final mean of PCNA+ cells per group was: in group 1, 17.57 ± 6.77; in group 2, 19.31 ± 5.30; in group 3, 27.46 ± 11.55; and, in group 4, 12.40 ± 5.23. There was no significant difference at the two evaluation times in the control group (p=0.491), but there was in the experimental group (p=0.020), with a lower number of PCNA+ cells on the seventh day. The comparison between the two groups, on the first day, showed more PCNA+ cells in the livers of the animals that received ASA (p=0.047), and on the seventh day the number was lower in the experimental group (p=0.007). Conclusion: ASA induced greater hepatocyte proliferation.

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Cicatrização da parede abdominal após hepatectomia parcial

Cited by 2 publications

References 19 publications

Comparison of J-Shaped Incision and Mercedes Incision for Liver Transplantation

Comparison of J-Shaped Incision and Mercedes Incision for Liver Transplantation

Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats

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