CIDE-A gene expression in patients with abdominal obesity and LDL hyperlipoproteinemia qualified for surgical revascularization in chronic limb ischemia

Feldo, Marcin; Kocki, Janusz; Lukasik, S; Bogucki, Jacek; Feldo, Jan; Terlecki, Piotr; Kęsik, Jan; Wroński, Jacek; Zubilewicz, Tomasz

doi:10.2478/pjs-2013-0097

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…This britening process was independent of demographics and body mass index. These preliminary studies complimented the role of CIDEA in healthy metabolic phenotype in humans (Dahlman et al., 2005, Feldo et al., 2013, Gummesson et al., 2007, Nordstrom et al., 2005, Puri et al., 2008, Wu et al., 2013, Zhang et al., 2008).…”

Section: Resultsmentioning

confidence: 75%

“…Various studies have shown a positive association of CIDEA expression with healthy metabolic phenotype in humans (Dahlman et al., 2005, Feldo et al., 2013, Gummesson et al., 2007, Nordstrom et al., 2005, Puri et al., 2008, Wu et al., 2013, Zhang et al., 2008). Our present study deciphers a comprehensive cellular and molecular mechanism of CIDEA in the regulation of improved metabolism via regulating thermogenesis and britening by transcriptional regulation of UCP1 in humans (Figure 6I).…”

Section: Discussionmentioning

confidence: 99%

“…Originally thought to be a mitochondrial protein, CIDEA was later discovered to be a lipid droplet (LD)-associated protein (Christianson et al., 2010, Puri et al., 2008, Reynolds et al., 2015) not localized to mitochondria in adipocytes. Unlike in mice (Zhou et al., 2003), CIDEA expression in human adipocytes correlates with insulin sensitivity (Puri et al., 2008) and lipid disorders in obese patients (Feldo et al., 2013). Furthermore, a CIDEA polymorphism has been associated with a clinical metabolic phenotype (Dahlman et al., 2005, Nordstrom et al., 2005, Wu et al., 2013, Zhang et al., 2008).…”

Section: Introductionmentioning

confidence: 99%

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CIDEA Transcriptionally Regulates UCP1 for Britening and Thermogenesis in Human Fat Cells

et al. 2019

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SummaryOur study identifies a transcriptional role of cell death-inducing DNA fragmentation factor-like effector A (CIDEA), a lipid-droplet-associated protein, whereby it regulates human adipocyte britening/beiging with consequences for the regulation of energy expenditure. The comprehensive transcriptome analysis revealed CIDEA's control over thermogenic function in brite/beige human adipocytes. In the absence of CIDEA, achieved by the modified dual-RNA-based CRISPR-Cas9nD10A system, adipocytes lost their britening capability, which was recovered upon CIDEA re-expression. Uncoupling protein 1 (UCP1), the most upregulated gene in brite human adipocytes, was suppressed in CIDEA knockout (KO) primary human adipocytes. Mechanistically, during induced britening, CIDEA shuttled from lipid droplets to the nucleus via an unusual nuclear bipartite signal in a concentration-dependent manner. In the nucleus, it specifically inhibited LXRα repression of UCP1 enhancer activity and strengthened PPARγ binding to UCP1 enhancer, hence driving UCP1 transcription. Overall, our study defines the role of CIDEA in increasing thermogenesis in human adipocytes.

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Section: Resultsmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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CIDEA Transcriptionally Regulates UCP1 for Britening and Thermogenesis in Human Fat Cells

et al. 2019

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“…This study investigated, for the first time, to our knowledge, the expression of CIDEA in a group of adolescent girls with obesity and different patterns of abdominal body fat distribution. Although, in the current study, no direct comparisons were made with adult forms of obesity, a reduction in CIDEA expression associated with markers of IR has been described in adults with obesity (14,21,22,37,38).…”

Section: Discussionmentioning

confidence: 72%

CIDEA expression in SAT from adolescent girls with obesity and unfavorable patterns of abdominal fat distribution

Tarabra

Nouws

Vash‐Margita

et al. 2021

Obesity

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Objective: This study investigated whether variations in cell death-inducing DNA fragmentation factor alpha subunit-like effector A (CIDEA) mRNA expression and protein levels are modulated by the pattern of abdominal fat distribution in adolescent girls with obesity. Methods: This study recruited 35 adolescent girls with obesity and characterized their abdominal fat distribution by magnetic resonance imaging. Participants had only a periumbilical/abdominal (n = 14) or a paired abdominal and gluteal subcutaneous adipose tissue (SAT) biopsy (n = 21). CIDEA expression was determined by reverse transcription-polymerase chain reaction, CIDEA protein level by Western blot, and the turnover of adipose lipids and adipocytes by 2 H 2 O labeling. In six girls, a second abdominal SAT biopsy was performed (after ~34.2 months) to explore the weight gain effect on CIDEA expression in abdominal SAT.Results: CIDEA expression decreased in abdominal SAT from participants with high visceral adipose tissue (VAT)/(VAT+SAT); CIDEA inversely correlated with number of small adipocytes, with the increase in preadipocyte proliferation, and with adipogenesis. A strong inverse correlation was found between CIDEA protein level with the newly synthetized glycerol (r = −0.839, p = 0.0047). Following weight gain, an increase in adipocytes' cell diameter with a decrease in CIDEA expression and RNAsequencing transcriptomic profile typical of adipocyte dysfunction was observed.Conclusions: Reduced expression of CIDEA in girls with high VAT/(VAT+SAT) is associated with adipocyte hypertrophy and insulin resistance.

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In silico interactions of statins with cell death-inducing DNA fragmentation factor-like effector A (CIDEA)

Barreto

González

Reiner

et al. 2021

Chemico-Biological Interactions

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CIDE-A gene expression in patients with abdominal obesity and LDL hyperlipoproteinemia qualified for surgical revascularization in chronic limb ischemia

Abstract: Due to an important role of Cide-A protein demonstrated in the development of metabolic diseases such as obesity, metabolic syndrome, type 2 diabetes and their vascular complications, CIDE -A gene and protein are potential therapeutic targets in the case of these diseases.

Cited by 3 publications

References 15 publications

CIDEA Transcriptionally Regulates UCP1 for Britening and Thermogenesis in Human Fat Cells

CIDEA Transcriptionally Regulates UCP1 for Britening and Thermogenesis in Human Fat Cells

CIDEA expression in SAT from adolescent girls with obesity and unfavorable patterns of abdominal fat distribution

In silico interactions of statins with cell death-inducing DNA fragmentation factor-like effector A (CIDEA)

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