In silico interactions of statins with cell death-inducing DNA fragmentation factor-like effector A (CIDEA)

Barreto, George E.; González, Janneth; Reiner, Željko; Jamialahmadi, Tannaz; Echeverrı́a, Valentina; Ashraf, Ghulam Md; Sahebkar, Amirhossein

doi:10.1016/j.cbi.2021.109528

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…С помощью спектроскопии и молекулярного докинга установлено взаимодействие ловастатина с малой бо роздкой различных фрагментов ДНК тимуса, ведущее к их конформационными изменениями [25]. Аторвастатин и розувастатин могут связываться с вызывающим гибель клеток эффектором А, подобным фактору фрагментации ДНК (CIDEA), образуя комплекс, участвующий в метабо лизме липидов и регуляции апоптоза [26]. Статины ока зывают регуляторное воздействие на ингибиторы диф ференцировки Id1, Id3, которые вовлечены в контроль клеточного цикла, старения, дифференцировки клеток и ангиогенеза [27].…”

Section: Introductionunclassified

Prospects for the use of statins in antiviral therapy

Мустафин

2023

CMAC

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Inhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies have shown antiviral efficacy of statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses. The ability of statins to inhibit influenza viruses, COVID-19, RSV, HIV, as well as Ebola, Zika, Dengue, Coxsackie, rotaviruses, ADV, HDV, HHV was experimentally confirmed. Statins can also enhance the effects of antiviral drugs, making them more effective in treating infections. Therefore, the use of statins in the complex therapy of viral infections is promising. In addition, the role of influenza viruses, T-cell leukemia and herpesviruses, HIV, HBV, HCV, HPV in the development of atherosclerosis has been identified, so the use of statins in complex treatment is also necessary to correct endothelial dysfunction that occurs under the influence of viruses. Since the activity of retroelements that are evolutionarily related to exogenous viruses increases with aging, it has been suggested that retrotransposons can also be targets for statins. This is evidenced by a change in the expression of non-coding RNAs under the action of statins, since the key sources of non-coding RNAs are retroelements. This property may be an additional factor in the prescription of statins to increase life expectancy, in addition to the prevention and treatment of atherosclerosis, since pathological activation of retroelements are the causes of aging. Viruses, like retroelements, are involved in the pathogenesis of malignant neoplasms, in the treatment of which statins have shown their effectiveness and the ability to enhance the effect of anticancer drugs, overcoming chemoresistance (similar to the potentiation of antiviral drugs). One of the mechanisms of this activity of statins may be their effect on retroelements and viruses.

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Section: Introductionunclassified

Prospects for the use of statins in antiviral therapy

Мустафин

2023

CMAC

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“…In spite of the fact that several new lipid-lowering medications have been introduced in the past decade [26][27][28], statins still remain as the most widely used class of medications prescribed for atherosclerotic cardiovascular disease hyperlipidemia [29,30]. Statins have interesting pleiotropic properties [31][32][33][34][35][36][37][38][39][40], which attract the attention of researchers to use them as potential drugs for improving the recovery and reducing the severity of TBI [29,41,42]. According to Fig.…”

Section: Introductionmentioning

confidence: 99%