Cigarette smoking and risk of pancreatic cancer: a clinic-based case-control study in the San Francisco Bay Area

Lea, C. Suzanne; Holly, Elizabeth A.; Bracci, Paige M.

doi:10.1016/j.annepidem.2015.08.011

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…For these reasons, both the College of American Pathologists and the Royal College of Pathologists of Canada have put forth recommendations on how the pathological examinations of a pancreatic resections should be performed to reduce the variability of reporting [27]. These recommendations have been implemented in our centre only during the last three years.…”

Section: Discussionmentioning

confidence: 99%

Are Quality Indicators associated with Postoperative Outcomes after Resection for Pancreatic Adenocarcinoma?

Hurton¹,

Urquhart²,

Kendall³

et al. 2016

Pancreat Disord Ther

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Section: Discussionmentioning

confidence: 99%

Are Quality Indicators associated with Postoperative Outcomes after Resection for Pancreatic Adenocarcinoma?

Hurton¹,

Urquhart²,

Kendall³

et al. 2016

Pancreat Disord Ther

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“…Smoking cessation is probably the only available preventive measure for pancreatic cancer [ 103 ]. However, there are some publications that did not find a correlation between smoking and PDAC [ 104 ]. The mechanisms involved have not been clearly established as yet [ 105 ].…”

Section: Part 1: Pancreatic Cancer Riskmentioning

confidence: 99%

Earlier Diagnosis of Pancreatic Cancer: Is It Possible?

Koltai

2023

Cancers

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Pancreatic ductal adenocarcinoma has a very high mortality rate which has been only minimally improved in the last 30 years. This high mortality is closely related to late diagnosis, which is usually made when the tumor is large and has extensively infiltrated neighboring tissues or distant metastases are already present. This is a paradoxical situation for a tumor that requires nearly 15 years to develop since the first founding mutation. Response to chemotherapy under such late circumstances is poor, resistance is frequent, and prolongation of survival is almost negligible. Early surgery has been, and still is, the only approach with a slightly better outcome. Unfortunately, the relapse percentage after surgery is still very high. In fact, early surgery clearly requires early diagnosis. Despite all the advances in diagnostic methods, the available tools for improving these results are scarce. Serum tumor markers permit a late diagnosis, but their contribution to an improved therapeutic result is very limited. On the other hand, effective screening methods for high-risk populations have not been fully developed as yet. This paper discusses the difficulties of early diagnosis, evaluates whether the available diagnostic tools are adequate, and proposes some simple and not-so-simple measures to improve it.

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“…However, there are also studies showing contradictory data to those described above. A clinic-based control study by Lea et al [ 24 ] including a population of the San Francisco Bay Area recruited patients between 2006 and 2011, and revealed no significant association between cigarette smoking and PC. No association was found for either former (OR = 0.85, 95% confidence interval [CI] = 0.66–1.1) or current cigarette smoking (men: OR = 1.0, 95% CI = 0.60–1.7; women: OR = 1.2, 95% CI = 0.73–2.1).…”

Section: Modifiable Risk Factors For Pcmentioning

confidence: 99%

Modifiable and Non-Modifiable Risk Factors for the Development of Non-Hereditary Pancreatic Cancer

Bułdak

2022

Medicina

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Pancreatic cancer is becoming an increasing healthcare concern. Though it is a 14th most common cancer worldwide, its incidence is steadily rising. Results of currently available therapies are still not satisfactory. Therefore, great attention should be put on the identification and reduction of risk factors for pancreatic cancer. A thorough up-to-date review of available data on the impact of well-established and novel risk factors of pancreatic cancer development have been performed. Several risk factors associated with lifestyle have significant impact on the risk of pancreatic cancer (i.e., smoking, obesity, alcohol consumption). Physicians should also be aware of the novel findings suggesting increasing role of microbiome, including viral and bacterial infections, in the development of pancreatic cancer. A growing body of evidence suggest also an increased risk during certain occupational exposures. In general, lifestyle seems to be a major contributor in the development of pancreatic cancer. Special attention should be given to individuals with a vicious cluster consisting of metabolic syndrome, tobacco smoking and alcohol consumption. Physicians should urge patients to comply to healthy diet, cessation of smoking and moderation of alcohol consumption, which may halve pancreatic cancer incidence. Further studies are warranted to explore the potential use of therapeutic approach on novel risk factors (e.g., microbiome).

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Cigarette smoking and risk of pancreatic cancer: a clinic-based case-control study in the San Francisco Bay Area

Cited by 5 publications

References 49 publications

Are Quality Indicators associated with Postoperative Outcomes after Resection for Pancreatic Adenocarcinoma?

Are Quality Indicators associated with Postoperative Outcomes after Resection for Pancreatic Adenocarcinoma?

Earlier Diagnosis of Pancreatic Cancer: Is It Possible?

Modifiable and Non-Modifiable Risk Factors for the Development of Non-Hereditary Pancreatic Cancer

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