Ciliary Body and Choroidal Melanomas Treated by Proton Beam Irradiation

Seddon, Johanna M.; Gragoudas, Evangelos S.; Albert, Daniel M.

doi:10.1001/archopht.1983.01040020404014

Cited by 66 publications

(37 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…10 Accordingly, in our patient, in whom the interval from treatment to enucle¬ ation was far longer than in any of the previously reported cases ( Table), the degree of tumor necrosis was more marked than it had been in other eyes, and the proportion of apparently via¬ ble residual tumor cells was consider¬ ably lower.…”

Section: Effect Of Irradiation On Tumor Sizementioning

confidence: 45%

Pathologic Examination of Ciliary Body Melanoma Treated With Proton Beam Irradiation

Ferry¹,

Blair²,

Gragoudas³

et al. 1985

Archives of Ophthalmology

View full text Add to dashboard Cite

Section: Effect Of Irradiation On Tumor Sizementioning

confidence: 45%

Pathologic Examination of Ciliary Body Melanoma Treated With Proton Beam Irradiation

Ferry¹,

Blair²,

Gragoudas³

et al. 1985

Archives of Ophthalmology

View full text Add to dashboard Cite

“…The anatomy of the rabbit optic nerve and the behavior of its nerve fibers in the context of demyelinization and remyelinization have been studied extensively in the rabbit [12, 13, 14], facilitating comparison of our data with the literature. Furthermore, we have used the same treatment parameters as for the treatment of malignant melanomas in man with an accelerated proton beam [2, 3, 4, 5, 15, 16, 17, 18]. In addition, most cases, which have been reported in the literature, were investigated with histology only after radiation neuropathy had already become clinically visible.…”

Section: Discussionsupporting

confidence: 42%

“…Uveal melanoma is the most frequent malignant intraocular tumor, and several modalities of treatment have been advocated including radiation therapy with brachytherapy [1]as well as, in recent years, with an accelerated proton beam [2, 3, 4, 5]. Although the tumors are located close to the optic disk in only 5.6% of cases, irradiation of the optic nerve cannot be avoided in up to 74% of these patients [6], and damage to the optic nerve with ensuing severe visual loss may occur after irradiation with an average lag of about 12 months (range: 6–36 months) [7].…”

Section: Introductionmentioning

confidence: 44%

Subclinical Experimental Optic Neuropathy after Accelerated Proton Beam Irradiation

et al. 2002

View full text Add to dashboard Cite

Background: Accelerated proton beam irradiation has been used for several years to treat intraocular tumors. The pathophysiology of proton-beam-induced retinopathy and neuropathy has not been characterized to date. The present study investigates the early effects of irradiation with an accelerated proton beam on the optic nerve of the rabbit. Materials and Methods: The optic nerve head of Albino New Zealand rabbits (n = 14) was irradiated with a narrow beam of accelerated protons using the total dose of 60 and 43 Gy, respectively. This dose was split up into 4 equal sessions taking place on 4 consecutive days. Ophthalmoscopic examination was performed regularly, and the rabbits were sacrificed at 1, 3 and 8 months after irradiation. The eyes were enucleated and processed for light and electron microscopy. Results: Despite the absence of ophthalmoscopically detectable optic neuropathy in all 14 rabbits irrespective of the dose of irradiation, light and electron microscopy of the optic nerve showed a glial and fibrotic perivascular scar made up predominantly of altered astrocytes. This scar formation was seen as early as 1 month after irradiation and was at times accompanied by infiltration with inflammatory cells perivascularly both outside and within the optic nerve. In contrast to the astrocytes, oligodendrocytes did not show degenerative cellular alterations. During the 8-month follow-up, no signs of vascular occlusion were found. Conclusions: The observed lesions in the glial tissues with consecutive fibrosis appear to stem from a direct effect of irradiation. This may represent the initial mechanism of early subclinical irradiation-induced damage to the optic nerve before vascular occlusions may occur at a later stage, which may lead to more severe damage.

show abstract

“…Nonetheless, they often contain viable-appearing tumor cells. [25][26][27][28][29][30][31][32] In studies ofseveral human malignancies, histologically monitored mitotic activity did not correlate with tumor growth.33 '34 In tumors such as uveal melanoma that have relatively slow doubling times, histologic studies of mitotic activity are insensitive measures of cell cycling. [35][36][37][38][39] A number of constraints have restricted the usefulness of tissue culture techniques to study the effectiveness of radiation therapy in uveal melanoma.…”

Section: Introduction Uveal Melanomas Have Been Treated With a Numbermentioning

confidence: 46%

DNA Cell Cycle Studies In Uveal Melanoma

Char¹,

Huhta²,

Waldman³

1989

American Journal of Ophthalmology

View full text Add to dashboard Cite

Ciliary Body and Choroidal Melanomas Treated by Proton Beam Irradiation

Cited by 66 publications

References 11 publications

Pathologic Examination of Ciliary Body Melanoma Treated With Proton Beam Irradiation

Pathologic Examination of Ciliary Body Melanoma Treated With Proton Beam Irradiation

Subclinical Experimental Optic Neuropathy after Accelerated Proton Beam Irradiation

DNA Cell Cycle Studies In Uveal Melanoma

Contact Info

Product

Resources

About