Pathologic Examination of Ciliary Body Melanoma Treated With Proton Beam Irradiation

Ferry, Andrew P.; Blair, Charles J.; Gragoudas, Evangelos S.; Volk, Stephan C.

doi:10.1001/archopht.1985.01050120083027

Cited by 38 publications

(27 citation statements)

References 9 publications

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“…17 They describe an inflammatory reaction essentially involving the anterior chamber and anterior vitreous, as observed in our patients. Intraocular pressure can also be elevated 18.…”

Section: Discussionsupporting

confidence: 66%

Intraocular inflammation after proton beam irradiation for uveal melanoma

Lumbroso

Desjardins²,

Lévy³

et al. 2001

British Journal of Ophthalmology

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Aim-To describe the inflammatory reaction that can occur following proton beam irradiation of uveal melanomas based on a large series of patients and to try to determine the risk factors for this reaction. Ocular inflammation usually consisted of mild anterior uveitis, resolving rapidly after topical steroids and cycloplegics. The incidence of inflammation after proton beam irradiation of melanomas seems higher than previously reported and is related to larger lesions. Evidence of inflammation associated with uveal melanoma has been described and seems to be associated with tumour necrosis (spontaneous or after irradiation). The appearance of transient inflammation during the follow up of these patients may be related to the release of inflammatory cytokines during tumour necrosis. Conclusion-Inflammation following proton beam irradiation is not unusual. It is correlated with larger initial tumours and may be related to tumour necrosis. (Br J Ophthalmol 2001;85:1305-1308 Radiation therapy is now a recognised conservative treatment option for uveal melanoma. The various modalities of radiation therapy include brachytherapy with scleral plaques and charged particle radiotherapy (protons or helium ions).

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“…17 They describe an inflammatory reaction essentially involving the anterior chamber and anterior vitreous, as observed in our patients. Intraocular pressure can also be elevated 18.…”

Section: Discussionsupporting

confidence: 66%

Intraocular inflammation after proton beam irradiation for uveal melanoma

Lumbroso

Desjardins²,

Lévy³

et al. 2001

British Journal of Ophthalmology

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“…Nonetheless, they often contain viable-appearing tumor cells. [25][26][27][28][29][30][31][32] In studies ofseveral human malignancies, histologically monitored mitotic activity did not correlate with tumor growth.33 '34 In tumors such as uveal melanoma that have relatively slow doubling times, histologic studies of mitotic activity are insensitive measures of cell cycling. [35][36][37][38][39] A number of constraints have restricted the usefulness of tissue culture techniques to study the effectiveness of radiation therapy in uveal melanoma.…”

Section: Introduction Uveal Melanomas Have Been Treated With a Numbermentioning

confidence: 47%

DNA Cell Cycle Studies In Uveal Melanoma

Char¹,

Huhta²,

Waldman³

1989

American Journal of Ophthalmology

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“…Even those patients in the highest risk group had a 76 _+ 7% probability of retaining the irradiated eye five years after treatment [35]. Pathological changes in eyes enucleated after proton beam treatment have been described [36][37][38][39].…”

Section: Eye Retention and Survivalsupporting

confidence: 39%

Proton therapy for uveal melanomas and other eye lesions

Munzenrider

1999

Strahlenther Onkol

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Charged particle beams are ideal for treating intra-ocular lesions, since they can be made to deposit their dose in the target, while significantly limiting dose received by non-involved ocular and orbital structures. Proton beam treatment of large numbers of uveal melanoma patients consistently achieves local control rates in excess of 95%, and eye retention rates of approximately 90%. Visual preservation is related to initial visual acuity, tumor size and location, and dose received by the macula, disc, and lens. The probability of distant metastasis is increased by larger tumor diameter, more anterior tumor location, and older patient age. Proton therapy is also effective treatment for patients with ocular angiomas, hemangiomas, metastatic tumors, and retinoblastomas, and may be beneficial for patients with exudative ("wet") age-related macular degeneration.

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Pathologic Examination of Ciliary Body Melanoma Treated With Proton Beam Irradiation

Cited by 38 publications

References 9 publications

Intraocular inflammation after proton beam irradiation for uveal melanoma

Intraocular inflammation after proton beam irradiation for uveal melanoma

DNA Cell Cycle Studies In Uveal Melanoma

Proton therapy for uveal melanomas and other eye lesions

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