Ciliary dyskinesia factors in cystic fibrosis and asthma

Wilson, Gregory B.; Fudenberg, H. Hugh

doi:10.1038/266463a0

Cited by 16 publications

(5 citation statements)

References 18 publications

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“…Firstly, ciliary activity in the presence of blood from non-allergic and allergic patients was examined. A ciliary dyskinesia factor in the serum of asthmatic patients has been reported previously (23]. In our study, however, neither blood from a non-allergic subject nor blood from allergic subjects affected the nasal ciliary activity of healthy guinea-pigs.…”

Section: Discussioncontrasting

confidence: 49%

Response of nasal ciliated cells of the guinea-pig during allergic reactions in human blood

Ōhashi¹,

Nakai²,

Ikeoka³

et al. 1988

Eur Respir J

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Nasal mucosal samples from thirty-five guinea-pigs were placed in a chamber, containing the medium RPMI 1640. Ciliary activity (beats.s-1) of the most active cell in each mucosal culture was measured using a photoelectric method. The RPMI 1640 was then replaced by 2 ml of RPMI 1640 and 1 ml of heparinized human blood from a non-allergic patient, with a ragweed-sensitive nasal allergy, or patients with D. farinae-sensitive nasal allergy: the ciliary activity of the same ciliated cell in each culture did not change significantly. We then added 1 micrograms of D. farinae extracts to evoke an in vitro allergic reaction. Ciliary excitation was induced when D. farinae extracts were added to the blood from D. farinae-sensitive subjects but not when added to blood from subjects without sensitivity to D. farinae. The peak and plateau of such an event occurred after 20-30 min. Ciliary stimulations were correlated with D. farinae-induced histamine release from whole blood. Thus, in vitro allergic reactions stimulate activity in cilia from normal nasal mucosa.

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Section: Discussioncontrasting

confidence: 49%

Response of nasal ciliated cells of the guinea-pig during allergic reactions in human blood

Ōhashi¹,

Nakai²,

Ikeoka³

et al. 1988

Eur Respir J

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“…Circulating kinins [1] and esterase activity [16] may be elevated and kininogen decreased [16] in asthma. Ciliary dyskinetic factors have been detected in asthmatic serum [150] as have indices for activation of complement [86]. Hence, the plasma of asthmatic subjects may be particularly noxious.…”

Section: Supply Of Mediatorsmentioning

confidence: 99%

“…Although their origin was not determined, anaphylatoxins have been identified in asthmatic sputa [98]. Asthmatic sputa have been demonstrated to produce smooth muscle contraction [36,54] and inhibition of ciliary motility [150]. The factors responsible for these effects may well have come from the serum.…”

Section: Sputum and Bronchial Lavagementioning

confidence: 99%

Plasma exudation and asthma

Persson

1988

Lung

119

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Several pieces of evidence support the view that exudation of plasma into the airway wall and into the airway lumen occurs in asthma. Vascular leakage of plasma results from inflammatory mediator-induced separation of endothelial cells in postcapillary venules belonging to the tracheobronchial circulation. Whereas proposed mediators of asthma induce reversible leakage, several antiasthma drugs exhibit antileakage effects in animals and humans. Potential consequences of plasma exudation are many. Mucosal/submucosal edema might contribute to airway hyperresponsiveness. Plasma exudate in the airway lumen in asthma may contribute to sloughing of epithelium, impairment of mucociliary transport, narrowing of small airways, and mucus plug formation. Exuded plasma may cause airway inflammation and constriction because of its content of powerful mediators, and chemoattractant factors and plasma proteins may condition the inflammatory cells abundant in asthmatic airways to release mediators in response to stimuli that otherwise would be innocuous to the cells. It is concluded that inflammatory stimulus-induced increase in macromolecular permeability of the tracheobronchial microvasculature and mucosa may be a significant pathogenetic mechanism in asthma and that the postcapillary venular endothelium and airway epithelium that regulate leakage of plasma are important effector cells in this disease.

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“…It was observed amid the study that serum from rabbits with bronchial asthma resulted in ciliary dyskinesia. (16) Together, the inflammation responses induced by asthma can result in more respiratory excreta and thicken the sputum, which might further decrease expectoration.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of COVID-19 patients with asthma in Wuhan, China: a retrospective cohort study

et al. 2020

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Objective Although it is reported that patients with coronavirus disease 2019 (COVID-19) disease who have comorbidities are at higher risk to suffer adverse clinical outcomes, there are inadequate evidence to clarify the association between COVID-19 and asthma. On this ground, this study aims to systematically analyze the clinical characteristics of COVID-19 patients with asthma. Methods In this single-center, retrospective and observational cohort study, 21 COVID-19 patients with asthma and 100 non-asthma COVID-19 patients were statistically matched by propensity score based on age, sex and comorbidities. Meanwhile, a collection and comparison concerning demographic indicators, clinical and laboratory examinations, treatments and outcomes were conducted between two groups to specify their differences. Results Statistically, the COVID-19 patients with asthma had a higher proportion of ICU admission (14.3% [3/21] vs. 2.1% [2/96] p = 0.040) than those who do not have. On top this, a higher level of inflammatory responses, such as interleukin 6, interleukin 8, procalcitonin, leukocytes, neutrophils and CD4 + T cells was presented in asthma patients. Moreover, the increase of organ damage indices like D-dimer, lactate dehydrogenase and high-sensitivity cardiac troponin I, were more pronounced in COVID-19 patients with asthma. Conclusions Exacerbated inflammatory responses and multiple organ damages were triggered in COVID-19 patients with asthma, which highlights more intensive surveillance and supportive treatment.

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Ciliary dyskinesia factors in cystic fibrosis and asthma

Cited by 16 publications

References 18 publications

Response of nasal ciliated cells of the guinea-pig during allergic reactions in human blood

Response of nasal ciliated cells of the guinea-pig during allergic reactions in human blood

Plasma exudation and asthma

Clinical characteristics of COVID-19 patients with asthma in Wuhan, China: a retrospective cohort study

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