Ciliated hepatic foregut cyst with extensive squamous metaplasia: report of a case

Mena, N. Ben; Zalinski, Stéphane; Svrcek, Magali; Lewin, M.; Fléjou, Jean‐François; Wendum, Dominique; Paye, François

doi:10.1007/s00428-006-0320-4

Cited by 31 publications

(13 citation statements)

References 12 publications

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“…One case had concomitant squamous cell carcinoma as well as gastric antral metaplasia, and one case had only gastric metaplasia [ 16 , 33 ]. Tumor marker serologies were performed in 4 of the metaplastic/malignant cases (3 squamous cell carcinoma, 1 squamous metaplasia), and all were within normal limits [ 10 , 13 , 15 , 17 ]. Our series reports the third case of gastric metaplasia arising within a CHFC, and it is the second known case of gastric metaplasia in CHFC not associated with malignancy.…”

Section: Discussionmentioning

confidence: 99%

Ciliated hepatic foregut cyst: a report of 6 cases and a review of the English literature

et al. 2015

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BackgroundCiliated hepatic foregut cyst (CHFC) is a rare cystic lesion most commonly identified in segment 4 of the liver that arises from the embryonic foregut. The classic histologic pattern is comprised of 4 distinct layers (inner ciliated epithelial lining, smooth muscle, loose connective tissue, fibrous capsule). Although rare, cases of metaplastic and malignant epithelial lining have been described in CHFC.MethodsWe report 6 additional cases of CHFC, one of which had gastric metaplasia of the cyst lining, and review all reported cases of CHFC in the English literature. We describe the clinicopathologic analysis of 6 cases, with selective immunohistochemical analysis on 1 case with gastric metaplasia.ResultsCases occurred in 4 women and 2 men (average age 55 years, range 42 to 67 years). Cysts ranged in size from 0.7 to 17 cm (average 7.2 cm) and were grossly tan-pink to white with blood-filled contents. The majority were located in segment 4 of the liver, however 2 were located in the porta hepatis. Tumor serologies (CA19-9 and/or CEA) were performed in 3 cases; 1 case demonstrated elevated CA19-9, and 2 cases had laboratory values within normal limits. All cases showed the classic histologic findings, however one case additionally had extensive gastric metaplasia.ConclusionsIn conclusion, CHFC is a rare diagnostic entity that should be considered in the differential diagnosis for cystic hepatic lesions, particularly those located in segment 4 of the liver. Metaplasia and squamous carcinoma can occur, therefore complete surgical excision is the recommended treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/s13000-015-0321-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Ciliated hepatic foregut cyst: a report of 6 cases and a review of the English literature

et al. 2015

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“…However, there have been cases reported with presentations of portal hypertension [18], jaundice [19], elevated liver enzymes [16,20], and right upper quadrant abdominal pain [9,12,17], which is typically moderate in severity and vague or gradual in onset. The sudden, severe pain observed in the current case is therefore unusual, and is intuitively, if not causally, related to the occurrence of hemorrhage, which is itself an uncommon finding, observed in only 6.2% of reported cases.…”

Section: Discussionmentioning

confidence: 99%

“…The most common histology was squamous cell carcinoma in 4 (80%) of the 5 cases of malignancy [7][8][9][10]; the other one was a cystadenocarcinoma arising within a CHFC [11]. Extensive squamous metaplasia was reported in one case [12]. The size of cysts that contained a malignancy (median 10 cm, range 3.2 -13 cm) was significantly greater that those that did not (median 3 cm, range <1 -11 cm, P < 0.01 by two-tailed Mann-Whitney test) (Figure 3).…”

Section: Literature Review and Analysismentioning

confidence: 99%

Ciliated Hepatic Foregut Cyst: 103 Cases in the World Literature

Ambe¹,

Gonzalez‐Cuyar²,

Farooqui³

et al. 2012

OJPathology

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Ciliated hepatic foregut cysts (CHFC) are rare, typically benign, lesions whose incidence has been increasing recently. Despite this increase in incidence, they remain rare and several key characteristics remain poorly understood, including the range of presentation and the risk of malignant conversion. To better understand CHFC, an extensive review of the international literature was performed. Characteristics including size, location, contents, presenting symptoms, and risk of malignancy were analyzed. In addition, an illustrative case is presented to highlight a potential pitfall in diagnosis: Although the presentation is thought to be typically painless or vaguely painful, these lesions may also present with hemorrhage and sudden severe abdominal pain. Importantly, although malignant degeneration is uncommon, analysis revealed that malignancy is significantly associated with size, which was significantly larger (median 10 cm) in malignant CHFC compared with the typical benign CHFC (3 cm) (p < 0.01). Large or symptomatic cysts, or small asymptomatic cysts that are atypical, should be resected.

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“…They are generally asymptomatic benign lesions and they generally do not communicate with the gallbladder although there is only one case communicating with the gallbladder [7]. Squamous metaplasia and even squamous cell carcinoma may arise in a hepatic foregut cyst [8, 9]. Laparoscopic excision is preferred for the treatment, as a minimally invasive procedure [10].…”

Section: Discussionmentioning

confidence: 99%

Ciliated Foregut Cyst of the Gallbladder: Report of a Case and Review of Literature

Bulut

Karayalçın

2010

Pathology Research International

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Cystic lesions of the gallbladder are very rare and they are generally lined by single columnar or mucinous epithelium. A ciliated cyst of foregut origin is extremely rare in gallbladder. To our knowledge, only five cases have been reported so far. Here, we present the sixth case found incidentally in ultrasonographic examination in a 41-year-old woman suffering from chronic right upper quadrant pain. Laparoscopic cholecystectomy was performed for the gallstones and a benign appearing cyst in ultrasonography. Macroscopically, a submucosal unilocular cyst was located in the neck of the gallbladder. There was no communication with the lumen. Histologically, the cyst was lined by pseudostratified ciliated epithelium containing goblet cells and had a muscular wall. The postoperative course was uneventful. Patient was discharged on the second day of the operation and was well after 2 months.

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Ciliated hepatic foregut cyst with extensive squamous metaplasia: report of a case

Cited by 31 publications

References 12 publications

Ciliated hepatic foregut cyst: a report of 6 cases and a review of the English literature

Ciliated hepatic foregut cyst: a report of 6 cases and a review of the English literature

Ciliated Hepatic Foregut Cyst: 103 Cases in the World Literature

Ciliated Foregut Cyst of the Gallbladder: Report of a Case and Review of Literature

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