Cilomilast, tacrolimus and rapamycin modulate dendritic cell function in the elicitation phase of allergic contact dermatitis

Abstract

DC migration into the draining lymph node also takes place in the elicitation phase of allergic contact dermatitis and this migration can be influenced by tacrolimus and rapamycin, and, to a lesser extent, by cilomilast.

Effect of Skin Sensitizers on Inducible Nitric Oxide Synthase Expression and Nitric Oxide Production in Skin Dendritic Cells: Role of Different Immunosuppressive Drugs

“…Although both bind to the same intracellular immunophilin, termed 12-kDa FK506-binding protein (FKBP12), the sirolimus-FKBP12 complex interacts with a distinct molecular target, known as mammalian target of rapamycin (mTOR), which results in the inhibition of multiple biochemical pathways critical for cytokine/growth factor-induced cellular proliferation, ribosome synthesis, translation initiation, and cell cycle progression into S phase (46) . Although sirolimus was shown recently to inhibit DC migration and DC-mediated T-cell activation (48) , our results indicated that sirolimus did not modify the levels of iNOS protein (Figure 3, lane 5, and Figure 5E) and NO production ( Figure 2) elicited by nickel sulfate.…”

Sirolimus (rapamycin): From the soil of Easter Island to a bright future

“…This is a key step in the elicitation phase of allergic contact dermatitis. 23 Thus, there may be a role for its use in selected patients with dermatitis.…”

Density of dendritic cells in the human tracheal mucosa is age dependent and site specific

“…[4][5][6][7][8][9][10][11] DC have been characterised in mouse models in non-lymphoid organs such as the skin, gut and lung. [12][13][14] The major relevance of DC in the uptake of particles in the bronchoalveolar space and the transport to the draining lymph node have recently been described, stressing the significant role of DC in the lung and their traffic to the lymph node. 15 DC are important in the pathophysiology of asthma and might help to explain the ''hygiene hypothesis'', as epidemiological observations suggest a vital role in the development of allergy and/or tolerance during early childhood.…”