2013
DOI: 10.1016/j.bbrc.2013.02.068
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Cilostazol promotes mitochondrial biogenesis in human umbilical vein endothelial cells through activating the expression of PGC-1α

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Cited by 19 publications
(13 citation statements)
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References 23 publications
(23 reference statements)
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“…Figure 6 illustrates that the PGC1a promoter and ERRa response element activity were significantly and dose-dependently increased by gromwell root extract. To confirm that the increased PGC1a promoter activity led to changes in gene expression, PGC1a mRNA levels were measured in HepG2 cells and in HUVECs (a frequently used model to study PGC1a gene expression and mitochondria biogenesis) (29)(30)(31). PGC1a gene expression was dose-dependently increased in both HepG2 cells (Figure 7A-7C) and HUVECs ( Figure 7D-7 F), which mirrored the promoter activity data.…”
Section: Obesitysupporting
confidence: 65%
“…Figure 6 illustrates that the PGC1a promoter and ERRa response element activity were significantly and dose-dependently increased by gromwell root extract. To confirm that the increased PGC1a promoter activity led to changes in gene expression, PGC1a mRNA levels were measured in HepG2 cells and in HUVECs (a frequently used model to study PGC1a gene expression and mitochondria biogenesis) (29)(30)(31). PGC1a gene expression was dose-dependently increased in both HepG2 cells (Figure 7A-7C) and HUVECs ( Figure 7D-7 F), which mirrored the promoter activity data.…”
Section: Obesitysupporting
confidence: 65%
“…It is well documented that PGC-1a, the master regulator of mitochondrial biogenesis, is regulated by cAMP response elementbinding protein (CREB) [18]. Activation of PGC-1a stimulates the expression of NRF-1 which consequently upregulates the function of TFAM to promote the mitochondrial biogenesis [9].…”
Section: Discussionmentioning
confidence: 99%
“…CREB signal pathway plays important role in mitochondrial biogenesis [18], therefore we investigated the role of CREB signal pathway in the neuroprotective effects of 14,15-EET. Up-regulation of phosphorylated CREB was observed in the cortical neurons treated with 14,15-EET.…”
Section: Creb Knockdown By Sirna Abolished the Protective Effects Of mentioning
confidence: 99%
“…The expression and activity of PGC-1α are affected by sirtuin-1 (SIRT1), a master regulator of mitochondrial biogenesis and function [6]. Activating the expression of PGC-1α in HUVECs promotes mitochondrial biogenesis and protects oxidative stress-induced endothelial dysfunction [7]. Previous studies have indicated that CTRP9 possesses potent vascular protective effect similar to adiponectin [8,9].…”
Section: Introductionmentioning
confidence: 98%