BackgroundPositive traits, such as life satisfaction, optimism, and core self-evaluation (CSE), have garnered increasing attention from researchers and professionals. However, the trilateral relationship among them remains unclear.ObjectiveThis study examines the effect of dispositional optimism on life satisfaction and primarily verified the mediator role of CSEs.MethodsSix hundred thirty college students from two general universities completed a questionnaire packet containing life orientation test–revised (LOT–R), core self-evaluations, and satisfaction with life scale. Confirmatory factor analysis (CFA) was conducted to assess the dimension of LOT–R. Bootstrap was used in structural equation modeling to analyze mediation effect.ResultsResults revealed that dispositional optimism and core self-evaluations were significantly correlated with life satisfaction. CFA identified the bidimensional structure of dispositional optimism. SEM indicated that core self-evaluations partially mediated the effect of dispositional optimism on life satisfaction. The final model also revealed significant paths from optimism and pessimism to life satisfaction through core-self evaluations.ConclusionThe findings extended prior studies and shed light on how dispositional optimism influences life satisfaction. This study provides valuable evidence on how to promote the life satisfaction of human beings in positive psychology. A further study can fully explore the relationship among them in multi-cultural follow-up studies.

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Context: Salvianolic acid B (Sal B) is regarded as a potent antidiabetic agent and has been reported to possess cardioprotective effect in vivo. Objective: This study investigated the cardioprotective effects of Sal B on H9c2 cells injury caused by high glucose in vitro, and clarified the possible mechanisms. Materials and methods: Di ferent concentrations of Sal B were incubated with cells for 12 h prior being exposed to high glucose for 24 h. Cardioprotective effects of Sal B were evaluated using CCK-8 assay, ELISA, Hoechst 33258 nucleus staining, and western blot. Results: Following a 24 h exposure of H9c2 to high glucose, obvious reduction was found in cell viability (45%), GSH (54.8 ± 9.4 ng/mg protein), catalase (1.22 ± 0.12 U/mg protein), and GPX level (67.9 ± 9.4 U/mg protein), which were associated with the increases of GSSG (1.99 ± 0.28 ng/mg protein) and ROS (2.00 ± 0.19 RFU/mg protein) production. High glucose also elevated IL-6 (1.8-fold), IL-1b (1.9-fold), and TNF-a (1.6-fold) level, as well as induced cell apoptosis and NF-kB (6.1-fold) activation. However, Sal B (25 and 50 mM) elevated cell viability (28% and 44%), ameliorated oxidative stress (GSH, 1.3-and 1.6-fold; catalase, 1.9-and 2.0-fold; GPX, 1.1-and 1.4-fold; GSSG, 0.9-and 0.8-fold; ROS, 0.6-and 0.5-fold), and inflammatory response (IL-6, 0.9-and 0.7-fold; IL-1b, 0.8-and 0.6-fold; TNF-a, 0.9-and 0.8-fold), and inhibited cell apoptosis and NF-kB (0.5-and 0.2-fold) expression. Conclusion: Sal B attenuated high glucose-induced injury and cytotoxicity through inhibiting inflammatory cytokine production in H9c2 cardiac cells. ARTICLE HISTORY

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