Cimetidine does not alter morphine disposition in man.

Mojaverian, Parviz; Fedder, IL; Vlasses, PH; Hh, Rotmensch; Ml, Rocci; Swanson, B N; Ferguson, RK

doi:10.1111/j.1365-2125.1982.tb02041.x

Cited by 36 publications

(9 citation statements)

References 28 publications

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“…Knodell et al (5) compared the effects of cimetidine (an imidazole ring structure) and ranitidine (a furan ring system) on the drug metabolizing activity of rat and human hepatic microsomes. Several recent studies suggest that the imidazole structure of cimetidine and its high binding affinity for cytochrome P450 (5) is primarily responsible for cimetidine-induced inhibition of hepatic drug metabolism rather than its Hj-receptor blocking activity (I, 3,5,8,[16][17][18][19]. ... zole Hy-antagonist, did not show any demonstrable effect on the pharmacokinetics of i.v.…”

Section: Discussionmentioning

confidence: 99%

Cimetidine versus famotidine: the effect on the pharmacokinetics of theophylline in rats

Mojaverian

Rocci

Saccar

et al. 1985

European Journal of Drug Metabolism and Pharmacokinetics

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The effects of cimetidine and a new, potent H2-antagonist, famotidine, on the single dose pharmacokinetics of theophylline were examined in rats. Male Sprague-Dawley rats (6 rats/group) received an i.v. dose of theophylline (6 mg/kg) alone and in conjunction with an i.v. dose of famotidine (10 mg/kg) or cimetidine (10 mg/kg). Venous blood samples were collected serially for seven hours after theophylline infusion and analyzed for theophylline concentration by HPLC. Concomitant famotidine administration did not alter any of the pharmacokinetic parameters of theophylline (AUC0- infinity; 38.1 +/- 8.7 vs. 38.8 +/- 6.3 micrograms.hr.ml-1), while cimetidine demonstrated a significant reduction in theophylline systemic clearance (0.11 +/- 0.02 vs. 0.16 +/- 0.02 L/hr/kg; p less than 0.001), a 40% prolongation of half-life (2.8 +/- 0.9 vs. 2.0 +/- 0.5 hr), with no change in the volume of distribution (0.39 +/- 0.1 vs. 0.41 +/- 0.13 L/kg). These results suggest that in contrast to cimetidine, famotidine, a non-imidazole H2-receptor antagonist, does not interfere with theophylline disposition in the rat.

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Section: Discussionmentioning

confidence: 99%

Cimetidine versus famotidine: the effect on the pharmacokinetics of theophylline in rats

Mojaverian

Rocci

Saccar

et al. 1985

European Journal of Drug Metabolism and Pharmacokinetics

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“…General anesthetics such as cyclopropane, halothane, methoxyflurane and nitrous oxide decrease hepatic blood flow and thus may decrease hydromorphone metabolism [5]. Cimetidine can potentiate opioids, presumably by altering hepatic blood flow and/ or extraction ratio [75]. Barbiturates, phenytoin, and rifampicin induce hepatic metabolism [112].…”

Section: Drug Interactionsmentioning

confidence: 99%

Hydromorphone: pharmacology and clinical applications in cancer patients

Sarhill

Walsh

Nelson

2001

Support Care Cancer

145

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Hydromorphone is a more potent opioid analgesic than morphine and is used for moderate to severe pain. It can be administered by injection, by infusion, by mouth, and rectally. Oral bioavailability is low. The kidney excretes hydromorphone and its metabolites. Some metabolites may have greater analgesic activity than hydromorphone itself but are unlikely to contribute to the pharmacological activity of hydromorphone. With the exception of pruritus, sedation and nausea and vomiting, which may occur less after hydromorphone than after morphine, the side-effects of these drugs are similar. On a milligram basis hydromorphone is five times as potent as morphine when given by the oral route, and 8.5 times as potent as morphine when given intravenously.

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“…Since cimetidine pretreatment appeared to have no effect on morphine pharmacokinetics (3) or on the relationship between morphine plasma con. centration and pupil diameter, additional analysis of the combined data was performed.…”

Section: Resultsmentioning

confidence: 99%