Cimetidine Hydrochloride Compatibility. I: Chemical Aspects and Room Temperature Stability in Intravenous Infusion Fluids

Rosenberg, Howard A.; Dougherty, John T.; Mayron, David; Baldinus, Joseph G.

doi:10.1093/ajhp/37.3.390

Cited by 6 publications

(5 citation statements)

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“…Cimetidine is compatible with standard intravenous solutions of electrolytes and dextrose or fructose [22,23] as well as with various types of parenteral nutrient solutions [24,25]; it can be mixed with these solutions to provide daily dosing with a single infusion set-up, which represents a potential savings in pharmacy costs to patients. Cimetidine may also reduce nursing time.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Cimetidine and Placebo for the Prophylaxis of Upper Gastrointestinal Bleeding Due to Stress-related Gastric Mucosal Damage in the Intensive Care Unit

Karlstadt¹,

Iberti

Silverstein

et al. 1990

J Intensive Care Med

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placebo for the prophylaxis of upper gastrointestinal bleeding due to stress-related gastric mucosal damage in the intensive care unit. J Intensive Care Med A multicenter, randomized, double-blind, placebocontrolled study was conducted with 87 patients in intensive care units to study the effectiveness of constant infusions of cimetidine (50 mg/hr) in the prophylaxis of stress-related mucosal bleeding. Fifty-four patients received cimetidine and 33 received placebo. The groups were comparable by age, sex, and severity of illness. One (2%) of the 54 patients receiving cimetidine had upper gastrointestinal hemorrhage and 7 (21%) of the 33 patients receiving placebo had upper gastrointestinal hemorrhage (p = 0.002). The risk of bleeding for every 100 patient days in intensive care units was reduced by 94% in the patients receiving cimetidine. Constant infusion cimetidine was well tolerated. Only one patient (cimetidine) developed pneumonia during the study, but it was not considered to be related to drug therapy. No patients experienced adverse drug interactions. Two patients (4%) experienced reversible side effects from treatment. Cimetidine, administered as a continuous intravenous 50-mg/hour infusion, is safe and significantly more effective than placebo for preventing upper gastrointestinal bleeding in critically ill patients.

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Section: Discussionmentioning

confidence: 99%

Comparison of Cimetidine and Placebo for the Prophylaxis of Upper Gastrointestinal Bleeding Due to Stress-related Gastric Mucosal Damage in the Intensive Care Unit

Karlstadt¹,

Iberti

Silverstein

et al. 1990

J Intensive Care Med

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“…The HPLC method was validated as stabilityindicating by accelerating the oxidative decomposition of cimetidine (1). Hydrogen peroxide (27% w/w, 0·1 ml) was added to cimetidine (100 g/ml) in 10 ml of TPN mixture and stored for 3 h at 50 C. The chromatogram showed an almost complete disappearance of the cimetidine peak, with decomposition peaks appearing at approximately 3 min and 5 min.…”

Section: Methodsmentioning

confidence: 99%

“…It is essential to ensure that cimetidine is physically compatible and chemically stable after it is added to such mixtures. Rosenberg et al (1) reported on the stability of cimetidine in a range of intravenous infusions including amino acids. Results indicated that cimetidine was stable for 7 days at ambient temperature.…”

Section: Introductionmentioning

confidence: 99%

Long-term stability of cimetidine in total parenteral nutrition

Haugaard¹,

Irving²

1996

J Clin Pharm Ther

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The stability of cimetidine (Tagamet) was investigated in total parenteral nutrition (TPN) mixtures containing different amino acid sources. TPN mixtures were stored at 5 degrees C in ethylvinyl acetate bags for 28 days and analysed by stability-indicating high-pressure liquid chromatography. Results indicated that cimetidine was physically compatible and chemically stable (less than 5% degradation) for at least 28 days in TPN mixtures containing either Freamine III, Vamin 14 or Aminoplex 12 as the amino acid source.

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“…This cyclization occurred over the entire pH range (2)(3)(4)(5)(6)(7)(8) which was investigated. The amine 4a (Scheme I) resulted from both nitrile hydrolysis and cyclization processes, while the cyanoarnine 4b (Scheme I) resulted from only cyclization.…”

Section: Resultsmentioning

confidence: 99%

“…Etintidine sulfoxide (5) and etintidine free base were obtained from Bristol Laboratories (Syracuse, NY). All other chemicals were reagent or HPLC grade.…”

Section: Methodsmentioning

confidence: 99%

Characterization of the Solution Degradation Products of Etintidine, An H2-Receptor Antagonist

Oyler

Naldi

Stefanick

et al. 1989

Journal of Pharmaceutical Sciences

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Cimetidine Hydrochloride Compatibility. I: Chemical Aspects and Room Temperature Stability in Intravenous Infusion Fluids

Cited by 6 publications

References 0 publications

Comparison of Cimetidine and Placebo for the Prophylaxis of Upper Gastrointestinal Bleeding Due to Stress-related Gastric Mucosal Damage in the Intensive Care Unit

Comparison of Cimetidine and Placebo for the Prophylaxis of Upper Gastrointestinal Bleeding Due to Stress-related Gastric Mucosal Damage in the Intensive Care Unit

Long-term stability of cimetidine in total parenteral nutrition

Characterization of the Solution Degradation Products of Etintidine, An H2-Receptor Antagonist

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