CIN 2/3 and Cervical Cancer After an ASCUS Pap Smear

Nygård, Jan F.; Sauer, Torill; Skjeldestad, Finn Egil; Skare, Gry Baadstrand; Thoresen, Steinar

doi:10.1159/000326673

Cited by 26 publications

(8 citation statements)

References 39 publications

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“…Most other studies provide information on CIN or worse after a single or initial BNC smear. In these studies CIN 1+ was found in 10–46% and CIN 2+ in 1.7–14% 7,8,9,12,13,20,23,24,26,29,30 . One study, focusing on atypical squamous metaplastic cells 25 even found CIN 1+ in 62% and CIN 2+ in 44%.…”

Section: Discussionmentioning

confidence: 95%

“…In these studies CIN 1+ was found in 10-46% and CIN 2+ in 1.7-14%. 7,8,9,12,13,20,23,24,26,29,30 One study, focusing on atypical squamous metaplastic cells 25 even found CIN 1+ in 62% and CIN 2+ in 44%. Carcinoma following a borderline result was reported in only a limited number of studies and in low frequencies, ranging from 0.1% to 3.8%.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Equivocal cytological abnormalities such as borderline nuclear changes (BNC) from the UK 1 and atypical squamous cells of undetermined significance (ASCUS) and atypical glandular cells (AGC) from Bethesda 2001 2 account for a considerable proportion of false positive results. [2][3][4][5][6][7][8][9][10][11][12][13] While being the least predictive of high-grade lesions, these equivocal abnormalities are usually found in high proportions. 3,4,6,7 ASC-US is defined as Ôcytologic changes that are suggestive of a squamous intraepithelial lesion, but lack criteria for a definitive interpretationÕ 2 where as BNC is used in cases where Ôthe pathologist has genuine doubt as to whether or not the cells are dyskaryoticÕ.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Referral compliance, outcome and predictors of CIN after repeated borderline cervical smears in the Netherlands

2007

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This finding may be used for prioritizing women for colposcopy on the basis of their age. More stringent use of the diagnosis of BNC, higher thresholds for colposcopically directed biopsy and introduction of HPV triage, combined with more specific new techniques or combination of techniques such as molecular markers for P16, MIB-1 and L1 may reduce the unnecessary high referral rate and over treatment of healthy women.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Referral compliance, outcome and predictors of CIN after repeated borderline cervical smears in the Netherlands

2007

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“…In the ASCUS/LSIL study, the diagnostic agreement was of only 55% of the submitted ASCUS cases [34]. Unfortunately, the low sensitivity of the Pap test in this regard affects millions of women because up to 5% of all Pap tests will be classified as ASCUS, and only a small subset of those patients (5-17%) will have a biopsy proving CIN II-III lesions, which definitely require treatment [36]. For this reason, methods for identifying those patients erroneously classified as ASCUS following Pap tests but more likely to have dysplasia are needed.…”

Section: Discussionmentioning

confidence: 99%

The Gastrin-Releasing Peptide Receptor as a Marker of Dysplastic Alterations in Cervical Epithelial Cells

Cornélio¹,

Meurer²,

Schwartsmann³

et al. 2012

Oncology

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Background: Cervical cancer is a leading cancer in women worldwide. The Papanicolaou test (Pap test) remains the main screening tool; however, it produces high rates of false-negative and false-positive results. Gastrin-releasing peptide is a growth factor that has been implicated in many cancers, and its main receptor, the gastrin-releasing peptide receptor (GRPR), is nearly always expressed in cervical dysplasias and invasive carcinomas. The aim of this study was to evaluate the diagnostic potential of GRPR immunocytochemistry in detecting cervical dysplasia and invasive cancer. Methods: Cervical smears were collected from 66 women in Brazil and subjected to GRPR immunocytochemistry and the Pap test. GRPR and p16 immunohistochemistry were performed in biopsies if abnormalities were detected. Results: GRPR immunostaining sensitivity in detecting cervical lesions was 87.5% and its specificity was 76.7%. GRPR immunostaining showed 80% accuracy in identifying atypical squamous cells of undetermined significance (ASCUS), with 88% sensitivity and 71% specificity. Conclusion: This is the first immunocytochemical evaluation of GRPR expression in cervical epithelial cells. This biomarker was strongly associated with cervical dysplasia and invasive cancers. GRPR immunosignaling showed high accuracy in detecting dysplasias in cells classified as ASCUS by Pap tests. Based on these results, immunocytochemistry for GRPR may be regarded as a valuable method for early detection of cervical intraepithelial neoplasia.

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Impact of the more restrictive definition of atypical squamous cells introduced by the 2001 Bethesda System on the sensitivity and specificity of the Papanicolaou test

Thrall

Pambuccian

Stelow

et al. 2008

Cancer

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CIN 2/3 and Cervical Cancer After an ASCUS Pap Smear

Cited by 26 publications

References 39 publications

Referral compliance, outcome and predictors of CIN after repeated borderline cervical smears in the Netherlands

Referral compliance, outcome and predictors of CIN after repeated borderline cervical smears in the Netherlands

The Gastrin-Releasing Peptide Receptor as a Marker of Dysplastic Alterations in Cervical Epithelial Cells

Impact of the more restrictive definition of atypical squamous cells introduced by the 2001 Bethesda System on the sensitivity and specificity of the Papanicolaou test

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