Cinguloparietal Atrophy Distinguishes Alzheimer Disease From Semantic Dementia

Boxer, Adam L.; Rankin, Katherine P.; Miller, Bruce L.; Schuff, Norbert; Weiner, Michael D.; Gorno‐Tempini, Maria Luisa; Rosen, Howard J.

doi:10.1001/archneur.60.7.949

Cited by 98 publications

(75 citation statements)

References 41 publications

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“…The findings of our MRI study highlight, as expected, significant GM reduction in the left temporal neocortex (temporal pole, and inferior, middle and superior temporal gyri), and at a lesser degree, in the right temporal neocortex, in accordance with previous quantitative volumetric [7,22,39] and VBM [4,25,26,29,49] studies. This pattern of results is in agreement with the severe semantic memory deficits in our group of SD patients.…”

Section: Discussionsupporting

confidence: 92%

“…Left amygdala atrophy in SD has recently been shown in VBM [4,25] and in volumetric [39,78] MRI studies, and seems to be more pronounced than in Alzheimer"s disease. Davies et al [12] have also stressed the involvement of the parahippocampal gyrus, more precisely, the perirhinal and entorhinal cortices, in SD.…”

Section: Discussionmentioning

confidence: 87%

“…Some studies have shown atrophy in other brain regions, notably the frontal lobes [39,49,64,69] and the amygdala [4,7,22,39,49,64,78]. It is worth noting that, with the evolution of the disease, SD patients develop executive dysfunction and behavioural symptoms [18], in accordance with the role of the frontal lobes in behaviour regulation.…”

Section: Introductionmentioning

confidence: 86%

“…In sum, only a few studies have applied the VBM procedure in SD [4,25,26,29,48,49,64]. Moreover, two of these studies investigated a small group of patients ([48] N = 4;…”

Section: Introductionmentioning

confidence: 99%

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Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Desgranges

Matuszewski

Piolino

et al. 2007

Neurobiology of Aging

140

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Rare studies have used MRI and voxel based morphometry (VBM) to assess atrophy, and only two PET studies used SPM to examine functional changes in semantic dementia (SD). Our aim was to highlight both morphological and functional abnormalities in a same group of 10 SD patients, in the entire brain, using a "state of the art" methodology (optimized VBM procedure, PET data corrected for partial volume effects and voxel based analyses). We also used an extensive neuropsychological battery. We showed that main alterations concerned the left temporal lobe, in accordance with the striking impairment of semantic memory in SD patients, as well as the hippocampal region, which may partly explain their moderate episodic memory deficits. Hypometabolism was more extensive than grey matter loss in both temporal lobes, and specifically concerned the orbitofrontal areas, consistent with the moderate impairment of executive functions and behavioural changes. While PET is more sensitive than MRI, there is striking concordance between morphological and functional abnormalities, which contrast with the discordance observed in Alzheimer"s disease and might be a typical feature of SD.3

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 86%

“…In sum, only a few studies have applied the VBM procedure in SD [4,25,26,29,48,49,64]. Moreover, two of these studies investigated a small group of patients ([48] N = 4;…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Desgranges

Matuszewski

Piolino

et al. 2007

Neurobiology of Aging

140

View full text Add to dashboard Cite

show abstract

“…10 In addition, voxel-based morphometry (VBM), 11 as an automated unbiased analysis of the differences in tissue concentration throughout the brain on structural MR imaging scans, has been widely used in brain tissue loss studies in AD. [12][13][14][15][16] These VBM studies reported bilateral gray matter loss in the hippocampus. However, the above 2 methods cannot accurately detect regional abnormalities of the hippocampal atrophy.…”

mentioning

confidence: 97%

Hippocampal Shape Analysis of Alzheimer Disease Based on Machine Learning Methods

Li¹,

Shi²,

Pu³

et al. 2007

American Journal of Neuroradiology

117

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Visual Assessment of Atrophy on Magnetic Resonance Imaging in the Diagnosis of Pathologically Confirmed Young-Onset Dementias

Likeman¹,

Anderson²,

Stevens³

et al. 2005

Arch Neurol

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Objectives: To investigate the diagnostic accuracy of visual inspection of magnetic resonance imaging (MRI) in a range of pathologically confirmed diseases causing young-onset dementia and to assess the sensitivity and specificity of atrophy patterns for Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD). Design: Sixty-two patients with pathologically confirmed diseases that may present as young-onset dementia were selected from a biopsy and postmortem series. The first diagnostic T1-weighted volumetric MRI was obtained for each patient, together with images from 22 healthy control subjects. All MRIs were assessed for regional atrophy independently by 3 neuroradiologists, blinded to all clinical details except age. Observers were also asked to use their clinical judgment to form a diagnosis. Results: Eighty-seven percent of dementia cases were distinguished from controls after visual inspection of MRI, and a correct pathologically confirmed diagnosis was given in 58% of cases. Hippocampal atrophy was noted in 92% of AD cases but was commonly seen in other dementias and controls. A bilateral symmetrical pattern of hippocampal atrophy discriminated AD from FTLD with 47% specificity, while posterior greater than anterior gradient of atrophy was 92% specific for AD. Atrophy of the anterior, inferior, and lateral temporal lobes was suggestive of FTLD pathology (Ն90% sensitivity), while anterior greater than posterior gradient of atrophy and hemispheric asymmetry of atrophy were each at least 85% specific for FTLD. Conclusion: Despite variation and overlap of atrophy patterns, visual inspection of regional atrophy on MRI may aid in discriminating AD and FTLD.

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Cinguloparietal Atrophy Distinguishes Alzheimer Disease From Semantic Dementia

Abstract: Alzheimer disease is associated with a specific pattern of cortical atrophy compared with SD.

Cited by 98 publications

References 41 publications

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Hippocampal Shape Analysis of Alzheimer Disease Based on Machine Learning Methods

Visual Assessment of Atrophy on Magnetic Resonance Imaging in the Diagnosis of Pathologically Confirmed Young-Onset Dementias

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