Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer

Kayahan, Münire; İdiz, Ufuk Oğuz; Güçin, Zühal; Erözgen, Fazilet; Memmı, Naim; Müslümanoğlu, Mahmut

doi:10.5152/tjbh.2014.1777

Cited by 8 publications

(7 citation statements)

References 33 publications

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“…The most detected tumor type was invasive ductal carcinoma (89.9%). This result was consistent with some literatures [3,6,7] and inconsistent with some of the literature with the largest population of breast cancer series [1,8]. 623 and 380 patients were included in these two published studies, respectively, and they found tumor type-histology was significantly related to ALM (p<0.001 and p=0.003, respectively).…”

Section: Discussionsupporting

confidence: 86%

“…Hormonal receptor status and Ki-67 proliferation index are studied for biological behavior of primary tumor [3]. Related to ER, PR, HER2, and Ki-67 index, molecular subtypes LA, LB, HER2 positive, and TN are formed.…”

Section: Discussionmentioning

confidence: 99%

“…Hormonal receptor status of the tumor as estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 proliferation index are important for ALM, subtyping and choice of treatment modality [1,2]. Other prognostic factors, also for ALM, are age, tumor subtypes as Luminal A (LA), Luminal B (LB), HER2 positive, and Triple negative (TN) according to St. Gallen Consensus 2013 [1,3], histological and nuclear grade, tumor size, multifocality, lymphovascular invasion and the stage of the tumor [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Impact of status of ER, PR, HER2 and Ki-67 index on axillary lymph node metastasis of breast cancer

Çakır¹,

Dogan²,

Akturk³

et al. 2020

Archives of Clinical and Experimental Medicine

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Aim: Axillary status evaluation and, if present, the number of metastatic lymph nodes is important in staging and adjuvant therapy planning of breast cancer. A number of clinical and pathological variables were analyzed to detect factors affecting nodal status. Methods: A total of 298 women with unilateral breast cancer operated with axillary lymph node dissection or sentinel lymph node biopsy, were retrospectively analyzed for age, localization, BIRADS category, pathological features, subtypes as Luminal A, Luminal B, HER2 positive, triple negative, Ki-67 index and number of lymph nodes involved. Results: The mean age was 54.7 years. BIRADS 5 was the most detected category in 208 (69.8%) patients. The most common pathological type was invasive ductal carcinoma in 265 patients (88.9%). The most detected tumor grade was grade 2 in 160 (31.2%). Luminal B was the most common subtype and detected in 173 patients (58.1%). Ki-67 indexes were detected between 0-14% in 69 patients (23.3%), between 15-19% in 31patients (10.4%) and above 20% in 198 patients (66.4%). Conclusions: HER2 positivity, Ki-67 index, and progesterone receptor negativity are the most significant factors affecting axillary lymph node metastasis.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of status of ER, PR, HER2 and Ki-67 index on axillary lymph node metastasis of breast cancer

Çakır¹,

Dogan²,

Akturk³

et al. 2020

Archives of Clinical and Experimental Medicine

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“…High Ki 67 expression is associated with higher histologic grade, larger tumor size, positive lymph node status, short disease-free survival, and overall survival in breast cancer [4,8,9].…”

Section: Discussionmentioning

confidence: 99%

Expression of E cadherin and Ki 67: Emerging Prognostic Markers in Triple-Negative Breast Cancer

Shetty

Rao

2019

Indian J Surg Oncol

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Triple-negative breast cancer (TNBC) is an aggressive subgroup of breast cancer which lacks effective target therapy. Expression of biomarkers is one of the important deciding factors for treatment strategies. The aim of this study was to evaluate expression of E cadherin and Ki 67 in relation to clinicopathological features. This prospective observational study included 141 cases of TNBC. Immunohistochemical staining was employed to analyze two biomarkers: E cadherin and Ki 67 on formalin-fixed paraffin-embedded tumor samples obtained from patients defined as TNBC. The age of the patients ranged from 26 to 84 years. Positive lymph nodes were found in 82 (58.1%). The tumor was grade 3 in 105 (74.4%). The E cadherin receptor was positive in 83 (58.8%). The Ki Index was > 10% in 89 (63.12%). The Ki 67 expression was significantly associated with a high nuclear grade (p = 0.000). The significant association noted between loss of E cadherin expression and positive lymph node (p = 0.0296). According to the results, TNBCs are frequently associated with the younger age groups, and the majority is poorly differentiated. The majorities of these have high expression of the Ki 67 and significantly associated with the higher nuclear grade. Loss of E cadherin was significantly associated with positive lymph nodes. Hence, evaluating the expression of E cadherin and Ki 67 routinely would be helpful for evaluating prognostic implications.

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“… 11 – 15 Many authors have reported significant associations between AR expression by cancer cells and improved overall survival and disease-free survival. 16 – 21 In addition, targeted therapy blocking AR receptors is being developed, and researchers are trying to better understand the molecular signaling pathways by which androgens alter the proliferation of cancer cells. It may be the only endocrine therapy available to a subset of patients with the aggressive triple negative tumors that lack the expression of ER, PR, and HER-2/neu, and hence, are unable to respond to targeted therapy.…”

mentioning

confidence: 99%

Expression of androgen receptor in invasive ductal breast carcinomas: a clinicopathological study from Jordan

Obeidat

Ahram

Khader

et al. 2018

Annals of Saudi Medicine

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BACKGROUNDThe clinical relevance of androgen receptors (ARs) expressed in breast cancer cells and the suggested prognostic impact has been an area of active research. The prevalence rate of AR expression in breast cancer has never been reported among Jordanian patients.OBJECTIVEDetermine the expression rate of ARs among invasive ductal breast cancer cases of different stages and molecular subtypes. Also, analyze the relationship between AR expression and clinicopathologic and immunohistochemical criteria, and assess the impact of AR expression on survival.DESIGNRetrospective medical record review.SETTINGTertiary care hospital in Amman, Jordan.PATIENTS AND METHODSOur study comprised only of cases of invasive ductal breast carcinoma of no special type among females from records during a 10-year period between 2006 and 2015. Immunohistochemical staining was considered positive if more than 10% of tumor nuclei showed positive staining.MAIN OUTCOME MEASURESThe expression rate of ARs and the association of the expression rate with the clinicopathologic features of invasive breast cancer.SAMPLE SIZE293.RESULTSImmunohistochemical staining for AR revealed positive staining in 180 (61.4%) cases, including approximately 50% of triple-negative breast cancer cases. AR positivity correlated with estrogen receptor (ER) status (P=.007) and smaller T size (P=.014). However, no significant association was found with any of the other variables. AR expression was positively associated with overall survival (P=.022) in general and in ER-positive cases (P=.012). However, in the multivariate Cox regression model, AR was not independently associated with survival.CONCLUSIONSThese results were consistent with international reports showing a significant relationship of AR expression with ER status. In addition, AR expression was significantly associated with smaller tumor size. Although AR status was not independently associated with survival, our data suggest AR is a good prognostic factor.LIMITATIONSSome clinical data were missing.

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Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer

Cited by 8 publications

References 33 publications

Impact of status of ER, PR, HER2 and Ki-67 index on axillary lymph node metastasis of breast cancer

Impact of status of ER, PR, HER2 and Ki-67 index on axillary lymph node metastasis of breast cancer

Expression of E cadherin and Ki 67: Emerging Prognostic Markers in Triple-Negative Breast Cancer

Expression of androgen receptor in invasive ductal breast carcinomas: a clinicopathological study from Jordan

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