Cinnamon extract inhibits degranulation and de novo synthesis of inflammatory mediators in mast cells

Abstract

CE decreases expression of mast cell-specific mediators in vitro and in vivo and thus is a new plant-originated candidate for anti-allergic therapy.

Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells

“…Cinnamon extract has anti-oxidative, antineoplastic, antidiabetic, anti-inflammatory, and anti-allergic effects both in vitro and in vivo [16,[24][25][26]. Ethanolic cinnamon extract has been shown to inhibit degranulation and phosphorylation of ERK 1/2 in RBL-2H3 cells and human intestinal mast cells [16]. Inhibitory effects of cinnamon water extract on phosphorylation of ERK1/2 and scavenger activity in macrophage has been revealed [26].…”

“…Based on these evidences, 4-chloro-cinnamaldehyde and 4-trifluoro-cinnamaldehyde could be a potential therapeutic agent for mast cell-related diseases. Cinnamon extract has anti-oxidative, antineoplastic, antidiabetic, anti-inflammatory, and anti-allergic effects both in vitro and in vivo [16,[24][25][26]. Ethanolic cinnamon extract has been shown to inhibit degranulation and phosphorylation of ERK 1/2 in RBL-2H3 cells and human intestinal mast cells [16].…”

“…Pro-inflammatory mediators such as TNF-α, IL-4, and COX-2 are crucial for allergic and inflammatory responses [4,[16][17][18][19][20][21][22][23]. We measured the effects of 4-chloro-cinnamaldehyde and 4-trifluorocinnamaldehyde on the relative gene expression of pro-inflammatory mediators in RBL-2H3 cells (Fig.…”

“…Therefore, RBL-2H3 cells are suitable for the study of allergic responses [12][13][14][15][16][17][18]. Phorbol myristate acetate (PMA), a PKC activator, and A23187, a calcium ionophore that functions to increase Ca 2+ influx, induce the activation of mast cells [7,19,20].…”

“…Cinnamon extract has been reported to have anti-oxidative, antineoplastic, antidiabetic, anti-inflammatory, and anti-allergic effects both in vitro and in vivo [16,[24][25][26]. Cinnamon extracts contain various compounds, including cinnamaldehyde, cinnamic acid, and cinnamate [24,27].…”