Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High‐Fat Diet‐Fed Rats

Abstract

We evaluated the effects of cinnamon polyphenol extract on hepatic transcription factors expressions including SREBP-1c and LXR-α in rats fed high fat diet (HFD). Twenty-eight Wistar rats were allocated into four groups: (i) normal control: animals fed with normal chow; (ii) cinnamon: animals supplemented with cinnamon polyphenol; (iii) HFD: animals fed a high-fat diet; and (iv) HFD + cinnamon: animals fed a high-fat diet and treated with cinnamon polyphenol. Obesity was linked to hyperglycemia, hyperlipidemia, and oxidative stress as imitated by elevated serum glucose, lipid profile, and serum and liver malondialdehyde (MDA) concentrations. Cinnamon polyphenol decreased body weight, visceral fat, liver weight and serum glucose and insulin concentrations, liver antioxidant enzymes, and lipid profile (P < 0.05) and reduced serum and liver MDA concentration compared to HFD rats (P < 0.05). Cinnamon polyphenol also suppressed the hepatic SREBP-1c, LXR-α, ACLY, FAS, and NF-κB p65 expressions and enhanced the PPAR-α, IRS-1, Nrf2, and HO-1 expressions in the HFD rat livers (P < 0.05). In conclusion, cinnamon polyphenol reduces the hyperlipidemia, inflammation, and oxidative stress through activating transcription factors and antioxidative defense signaling pathway in HFD rat liver.

Immunomodulatory and therapeutic role of Cinnamomum verum extracts in collagen-induced arthritic BALB/c mice

“…Cinnamaldehyde has been predicted to have an anti-oxidative function along with a protein modulatory function as outlined by our underlying hypothesis (Tulini et al 2016;Tuzcu et al 2017). Fig.…”

Prenylated flavonoid‐standardized extract from seeds of Psoralea corylifolia L. activated fat browning in high‐fat diet–induced obese mice

“…A large number of studies have reported the beneficial effects of dietary flavonoids on human health (Hossain et al, 2016). Numerous flavonoids including those in Paulownia fortunei flowers, green tea, and cinnamon have been found to protect against obesity-related complications, such as type 2 diabetes mellitus, cardiovascular disease, and nonalcoholic fatty liver disease (Liu et al, 2017;Tuzcu, Orhan, Sahin, Juturu, & Sahin, 2017;Yamashita et al, 2018). However, to our knowledge, there is no report on anti-obesity activity of prenylated flavonoids in the seeds of P. corylifolia L. We found that PFE protected against obesity and significantly reduced bodyweight, fat mass, and white adipose cells in the HFD-induced obese mice.…”

Wild Italian Prunus spinosa L. Fruit Exerts In Vitro Antimicrobial Activity and Protects Against In Vitro and In Vivo Oxidative Stress

“…( Figure 4C), and to the MDA content, in a dose-dependent manner ( Figure 4E). It has been demonstrated that plant polyphenols are related to the improvement of hepatic oxidative stress caused by a high-fat diet through the e activation of Nrf2 transcription factor, which increases expression of antioxidant enzymes [37]. Moreover, it was reported that even the single polyphenol, if isolated, can improve the high-fat-diet-induced hepatic oxidative stress, as in the case of rutin [33] and gallic acid [38].…”