Cinnamon Shows Antidiabetic Properties that Are Species-Specific: Effects on Enzyme Activity Inhibition and Starch Digestion

Hayward, Nicholas J.; McDougall, Gordon J.; Farag, S. O.; Allwood, J. William; Austin, Ceri; Campbell, Fiona; Horgan, Graham; Ranawana, Viren

doi:10.1007/s11130-019-00760-8

Cited by 49 publications

(26 citation statements)

References 35 publications

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“…238 C. burmanii, Vietnamese; C. loureirii and Ceylon; C. zeylanicum showed great potential to suppress the formation of AGEs. 239 In diabetic rats, cinnamon and its active component procyanidin-B2 (PCB2) inhibited AGE accumulation and ameliorated AGE-mediated pathogenesis of diabetic nephropathy. 240 It has also been reported that the procyanidin-B2 fraction has the physiological significance of delaying diabetic cataracts by repressing AGEs in diabetic rats.…”

Section: Improvement Of Diabetes Complicationsmentioning

confidence: 99%

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

et al. 2021

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Section: Improvement Of Diabetes Complicationsmentioning

confidence: 99%

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

et al. 2021

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“…All cinnamon types showed potent species-speci c effects on starch digestion enzyme activity inhibition. C. cassia was most effective against α-amylase and all tests strongly inhibited α-glucosidase when compared to acarbose 25 . Natural agents that slow carbohydrate absorption may mimic the protective effect of acarbose.…”

Section: Discussionmentioning

confidence: 95%

“…and many medicinal values including antitumor, anti‐inflammatory, analgesic, anti‐diabetic, anti‐obesity, antibacterial, antiviral, cardiovascular protective, cytoprotective, neuroprotective, immunoregulatory effects, and anti‐tyrosinase activity (Zhang et al., 2019). C. cassia was most effective against α‐amylase and all tests strongly inhibited α‐glucosidase when compared to acarbose (Hayward et al., 2019). Natural agents slowing carbohydrate absorption may mimic the protective or preventative effect of acarbose.…”

Section: Discussionmentioning

confidence: 99%

A nutraceutical combination of cinnamon, purple onion, and tea linked with key enzymes on treatment of type 2 diabetes

Weng¹,

Chen²,

Huang³

et al. 2021

J Food Biochem

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Background: Diabetes mellitus (DM) is concomitant with signi cant morbidity and mortality and its prevalence is accumulative worldwide. The conventional antidiabetic agents are known to mitigate the symptoms of diabetes; however, they may also cause adverse effects. This study explores the e cacy of polyherbal dietary supplement cinnamon, purple onion, and tea on the mediation of postprandial hyperglycemia for in the search of combinations with a maximal response.Materials and methods: A starch solution (3 g/kg Bwt) of oral starch tolerance test (OSTT) and glucose solution (4 g/kg Bwt) of oral glucose tolerance test (OGTT) with and without cinnamon, purple onion, tea extract (15 mg/kg Bwt), and mixture (each 5 mg/kg Bwt, 1:1:1), metformin (14 mg/kg Bwt), or acarbose (50 mg/kg Bwt) was administered to high fat plus high fructose-induced diabetic mice after an overnight fast. Postprandial plasma glucose levels were measured and incremental areas under the response curve were calculated.Results: Compared with acarbose, the mixture of extracts (purple onion, cinnamon, and tea) indicated decreasing blood glucose in OSTT. In OGTT, the mixture of extracts showed greater e cacy for hypoglycemia when compared with metformin. The molecular docking of α-Amylase, α-Glucosidase, and AMPK con rmed the putatively acting molecules from the extracts of purple onion, cinnamon, and tea.Conclusions: Overall, this investigation evidenced a bene cial mediation for the progression of lowering blood glucose with a combinatory extract of cinnamon, dietary onion, and tea, implicating their prospective as nutraceuticals that might ameliorate hyperglycemia in diabetes.

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“…Few clinical studies in humans also proved its effect against type 2 diabetes [9, 10]. Hayward et al [11] compared the anti-hyperglycaemic properties of the four major commercial cinnamon types used around the world namely Cinnamomum cassia (Chinese cinnamon), C. burmanii (Indonesian cinnamon), C. loureirii (Vietnamese cinnamon) and C. zeylanicum (Ceylon cinnamon). Among them, C. zeylanicum showed the greatest potential to inhibit the formation of advanced glycation end products (AGEs) during digestion thus proved its antihyperglycemic activity.…”

Section: Introductionmentioning

confidence: 99%

Phytotherapeutic potential of bi-herbal extract of cinnamon and turmeric: in vivo antidiabetic studies

2021

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Background The spices, cinnamon and turmeric have both culinary and pharmaceutical applications. Earlier studies proved their effect on reducing the symptoms associated with type 2 diabetes, a major lifestyle disease affecting millions world over. In our work, we prepared a bi-herbal extract of cinnamon and turmeric and studied its effect to alleviate the symptoms of type 2 diabetes in rat model. Method The phenolic rich bi-herbal extract was given to diabetes induced male wistar rats for 28 days at two different concentrations (50 and 150 mg/Kg bwt.). The changes in blood glucose level were monitored at weekly interval. At the end of the experiment, blood serum was collected and used for the estimation of lipid profile, Glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Total Protein (TP), Albumin, Urea and Creatinine levels. Result The serum analysis revealed that administration of the bi-herbal extract at 150 mg/Kg bwt. significantly reduced the blood glucose level (152.60 ± 40.2 mg/dL; p < 0.05) of diabetic animals as compared to diabetic control (335.40 ± 67.3 mg/dL; p < 0.05) at the end of 4 weeks. The treatment also resulted in the reduction of total cholesterol and LDL-cholestrol levels as compared to diabetic control animals. The histopathological examination of tissues showed the improvement in pancreatic architecture and restoration of tissue integrity in liver and kidney. Conclusion The study concludes that methanol extract of combination of cinnamon and turmeric has good hypoglycemic, hypolipidemic and organ protective potential in diabetic rats which could be developed into functional food supplementation for the prevention of type 2 diabetes.

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Cinnamon Shows Antidiabetic Properties that Are Species-Specific: Effects on Enzyme Activity Inhibition and Starch Digestion

Cited by 49 publications

References 35 publications

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

A nutraceutical combination of cinnamon, purple onion, and tea linked with key enzymes on treatment of type 2 diabetes

Phytotherapeutic potential of bi-herbal extract of cinnamon and turmeric: in vivo antidiabetic studies

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