Ciprofloxacin in neonatal Enterobacter cloacae septicaemia.

Abstract

rupture and dissection has been described and was the probable cause of death in five of the 51

Ciprofloxacin in preterm neonates: case report and review of the literature

“…Available knowledge on cipro¯oxacin therapy in very low birth weight (<1500 g) infants with neonatal infections (onset of infection before postconceptional age of 40 weeks) [1,5,7] comprises reports on 27 newborns. The infants gestational ages ranged from 24 to 37 weeks (mean 31 weeks), postnatal ages at the time of ciprooxacin therapy from 4 to 137 days (mean 28 days) and body weights from 800 to >2100 g (mean 1230 g).…”

“…Most of these patients were over 6 years of age and reports on the use of cipro¯oxacin in neonates are limited [1,3,5,7]. We report the use of cipro¯oxacin in a preterm infant with an invasive infection due to a multiresistant Enterobacter cloacae and review the available cipro¯oxacin information in preterm neonates.…”

“…The drug can be administered both orally [8] and parenterally, and has been shown to have an excellent tissue and CSF penetration [1]. Ciprooxacin has bactericidal activity against most aerobic Gram-negative micro-organisms and staphylococci.…”

Ciprofloxacin Treatment in Newborns with Multi-Drug-Resistant Nosocomial Pseudomonas<i></i>Infections

“…The patient was followed up to the age of 36 months and neurological fits, dental dyschromia and signs of arthorapthy were not observed. In another report, six premature infants who had had multi-resistant E. cloacae infection and were treated with ciprofloxacin did not show any side effects [9]. Isaac et al [10] reported the successful treatment of ventriculitis caused by a multi-resistant P. aeruginosa strain.…”

Successful treatment of multi-resistant Stenotrophomonas maltophilia meningitis with ciprofloxacin in a pre-term infant

“…In the published cases, patients have received up to 60 mg/kg per day of ciprofloxacin for up to 30 days [5,8,10]. Van den Oever et al [11] suggested, however, that an intravenous dose of 10-20 mg/kg per day is probably adequate for pre-term infants, as adequate peak serum levels (0.98-5.7 mg/l) are still demonstrated, even at relatively low doses (4-10 mg/kg per day) [1,5]. Indeed, adequate ciprofloxacin CSF penetration for meningitis has been established both in adults and infants of all ages (reaching about 65%-150% of serum levels) [4,11].…”