Ciprofloxacin‐releasing bioabsorbable polymer is superior to titanium in preventing <i>Staphylococcus epidermidis</i> attachment and biofilm formation <i>in vitro</i>

Niemelä, Sanna-Mari; Ikäheimo, Irma; Koskela, Markku; Veiranto, Minna; Suokas, Esa; Törmälä, Pertti; Waris, Timo; Ashammakhi, Nureddin; Syrjälä, Hannu

doi:10.1002/jbm.b.30414

Cited by 18 publications

(2 citation statements)

References 21 publications

(23 reference statements)

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“…The principle of local drug release has been developed to avoid or at least limit side effects of drugs. In many systems where implants are produced, heat-based processing systems are used to manufacture drug releasing implants, [116][117][118][119][120][121][122] making the inclusion of heat-sensitive molecules impossible. Employing e-spinning has enabled researchers to develop multifunctional fibers and scaffolds that are capable of releasing drugs, 19-26 83 86 123 124 polypeptides, 27-29 123-125 or polyneucleotiedes, 96 97 etc.…”

Section: Developed Nanomatsmentioning

confidence: 99%

Biodegradable Nanomats Produced by Electrospinning: Expanding Multifunctionality and Potential for Tissue Engineering

Ashammakhi

Ndreu²,

Piras³

et al. 2007

j nanosci nanotechnol

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With increasing interest in nanotechnology, development of nanofibers (n-fibers) by using the technique of electrospinning is gaining new momentum. Among important potential applications of n-fiber-based structures, scaffolds for tissue-engineering represent an advancing front. Nanoscaffolds (n-scaffolds) are closer to natural extracellular matrix (ECM) and its nanoscale fibrous structure. Although the technique of electrospinning is relatively old, various improvements have been made in the last decades to explore the spinning of submicron fibers from biodegradable polymers and to develop also multifunctional drug-releasing and bioactive scaffolds. Various factors can affect the properties of resulting nanostructures that can be classified into three main categories, namely: (1) Substrate related, (2) Apparatus related, and (3) Environment related factors. Developed n-scaffolds were tested for their cytocompatibility using different cell models and were seeded with cells for to develop tissue engineering constructs. Most importantly, studies have looked at the potential of using n-scaffolds for the development of blood vessels. There is a large area ahead for further applications and development of the field. For instance, multifunctional scaffolds that can be used as controlled delivery system do have a potential and have yet to be investigated for engineering of various tissues. So far, in vivo data on n-scaffolds are scarce, but in future reports are expected to emerge. With the convergence of the fields of nanotechnology, drug release and tissue engineering, new solutions could be found for the current limitations of tissue engineering scaffolds, which may enhance their functionality upon in vivo implantation. In this paper electrospinning process, factors affecting it, used polymers, developed n-scaffolds and their characterization are reviewed with focus on application in tissue engineering.

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Section: Developed Nanomatsmentioning

confidence: 99%

Biodegradable Nanomats Produced by Electrospinning: Expanding Multifunctionality and Potential for Tissue Engineering

Ashammakhi

Ndreu²,

Piras³

et al. 2007

j nanosci nanotechnol

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“…These authors also compared this implant function with titanium in preventing S. epidermidis attachment plus biofilm formation in culture media. PLGA/CIPreleasing material significantly suppressed the S. epidermidis attachment and biofilm formation in comparison to the titanium and pure PLGA (Niemelä et al, 2006a). In another formulation, the authors also added CIP and bioactive glass to the PLGA 80/20 and polylactide (P (L/DL) LA 70/30; afterward, the mixture was extruded and self-reinforced.…”

Section: Staphylococcus Epidermidismentioning

confidence: 99%

PLGA-Based Nanoplatforms in Drug Delivery for Inhibition and Destruction of Microbial Biofilm

Shariati

Chegini

Ghaznavi‐Rad

et al. 2022

Front. Cell. Infect. Microbiol.

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The biofilm community of microorganisms has been identified as the dominant mode of microbial growth in nature and a common characteristic of different microorganisms such as Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. The biofilm structure helps in the protection from environmental threats including host immune system and antimicrobial agents. Thus, the biofilm community has led to a higher prevalence of multidrug-resistant (MDR) strains in recent years. In this regard, the use of a new class of antibiotics, natural compounds, and anti-biofilm enzymes has been considered for the destruction of the microbial biofilm. However, different drawbacks such as low penetration, high susceptibility to degradation, instability, and poor solubility in aqueous solutions limit the use of anti-biofilm agents (ABAs) in a clinical setting. As such, recent studies have been using poly lactic-co-glycolic acid (PLGA)-based nanoplatforms (PLGA NPFs) for delivery of ABAs that have reported promising results. These particles, due to proper drug loading and release kinetics, could suppress microbial attachment, colonization, and biofilm formation for a long time. Additionally, PLGA NPFs, because of the high drug-loading efficiencies, hydrophilic surface, negative charge, and electrostatic interaction, lead to effective penetration of antibiotics to the deeper layer of the biofilm, thereby eliminating the microbial biofilm. Thus, PLGA NPFs could be considered as a potential candidate for coating catheters and other medical material surfaces for inhibition and destruction of the microbial biofilm. However, the exact interaction of PLGA NPFs and the microbial biofilm should be evaluated in animal studies. Additionally, a future goal will be to develop PLGA formulations as systems that can be used for the treatment of the MDR microbial biofilm, since the exact interactions of PLGA NPFs and these biofilm structures are not elucidated. In the present review article, we have discussed various aspects of PLGA usage for inhibition and destruction of the microbial biofilm along with different methods and procedures that have been used for improving PLGA NPF efficacy against the microbial biofilm.

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New injectable and radiopaque antibiotic loaded acrylic bone cements

et al. 2008

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The use of antibiotic loaded bone cements (ALBCs) has become a common clinical practice in the prevention and treatment of prosthesis-related infections. However, due to antibiotic resistance, there is a general interest in broadening the antibacterial spectrum of currently used drugs. The aim of this work is to formulate ALBCs for specific use in vertebroplasty and kyphoplasty, and to study the effect of the addition of ciprofloxacin alone and in combination with vancomycin on some properties of the cement. The cements were formulated using bismuth salicylate as the radiopacifier. The setting properties, residual monomer content, release of antibiotics, rheological behavior, injectability, and mechanical properties of these formulations were studied. They showed long setting times and low curing temperatures. From the release studies, antibacterial properties are assumed because the concentration of released antibiotic was higher than the minimum effective. Although the experimental cements had slightly reduced mechanical properties, the other alterations shown were negligible.

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Ciprofloxacin‐releasing bioabsorbable polymer is superior to titanium in preventing Staphylococcus epidermidis attachment and biofilm formation in vitro

Cited by 18 publications

References 21 publications

Biodegradable Nanomats Produced by Electrospinning: Expanding Multifunctionality and Potential for Tissue Engineering

Biodegradable Nanomats Produced by Electrospinning: Expanding Multifunctionality and Potential for Tissue Engineering

PLGA-Based Nanoplatforms in Drug Delivery for Inhibition and Destruction of Microbial Biofilm

New injectable and radiopaque antibiotic loaded acrylic bone cements

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