circ01592 regulates unsaturated fatty acid metabolism through adsorbing miR-218 in bovine mammary epithelial cells

Chen, Zhi; Cao, Xiang; Lu, Qinyue; Zhou, Jingpeng; Wang, Yuhao; Wu, Yonghong; Mao, Yongjiang; Xu, Huifen

doi:10.1039/d1fo02797b

Cited by 14 publications

(8 citation statements)

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“…In living organisms, free FAs, generally with low concentration, are mainly bound to fatty acid-binding proteins [11,12]. In this case, FAs in vivo are usually produced by the degradation of deposited fat and basically do not contain VLFCAs, and mitochondrial β-oxidation is the primary way of FAO.…”

Section: The Significance Of Peroxisomal β-Oxidationmentioning

confidence: 99%

The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation

Zong

Zhang

et al. 2022

Agriculture

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Beta-oxidation(β-oxidation) is an important metabolic process involving multiple steps by which fatty acid molecules are broken down to produce energy. The very long-chain fatty acids (VLCFAs), a type of fatty acid (FA), are usually highly toxic when free in vivo, and their oxidative metabolism depends on the peroxisomal β-oxidation. For a long time, although β-oxidation takes place in both mitochondria and peroxisomes, most studies have been keen to explore the mechanism of β-oxidation in mitochondria while ignoring the importance of peroxisomal β-oxidation. However, current studies indicate that it is hard to provide effective treatment for diseases caused by the disorder of peroxisomal β-oxidation, such as X-ALD, SCOX deficiency, and D-BP deficiency; thus, actions should be taken to solve this problem. Based on existing research results, this review will summarize the importance of peroxisomal β-oxidation and help further learning.

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Section: The Significance Of Peroxisomal β-Oxidationmentioning

confidence: 99%

The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation

Zong

Zhang

et al. 2022

Agriculture

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“…Interestingly, the tsRNA/miRNA/mRNA co-expression network revealed that SCD may be regulated by both tsRNAs and miRNAs (tRF-Gly-GCC-037, tRF-Gly-GCC-042, tRF-Gly-CCC-016, miR-218a, and miR-281b). A previous study on dairy cows found that miR-218 could be involved in unsaturated fatty acid metabolism through ELOVL5 [ 48 ]. ELOVL5 is one of the key enzymes in the synthesis of unsaturated fatty acids, and it has been widely reported to participate in the synthesis of long-chain unsaturated fatty acids in human [ 49 ], goat [ 50 ], fish [ 51 ], and pig [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

tsRNA Landscape and Potential Function Network in Subcutaneous and Visceral Pig Adipose Tissue

Wang

Liao

Lei

et al. 2023

Genes

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Noncoding RNAs (ncRNAs) called tsRNAs (tRNA-derived short RNAs) have the ability to regulate gene expression. The information on tsRNAs in fat tissue is, however, limited. By sequencing, identifying, and analyzing tsRNAs using pigs as animal models, this research reports for the first time the characteristics of tsRNAs in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). A total of 474 tsRNAs, 20 and 21 of which were particularly expressed in VAT and SAT, respectively, were found in WAT. According to the analysis of the tsRNA/miRNA/mRNA co-expression network, the tsRNAs with differential expression were primarily engaged in the endocrine and immune systems, which fall under the classification of organic systems, as well as the global and overview maps and lipid metropolis, which fall under the category of metabolism. This research also discovered a connection between the activity of the host tRNA engaged in translation and the production of tsRNAs. This research also discovered that tRF-Gly-GCC-037/tRF-Gly-GCC-042/tRF-Gly-CCC-016 and miR-218a/miR281b may be involved in the regulation of fatty acid metabolism in adipose tissue through SCD based on the tsRNA/miRNA/mRNA/fatty acid network. In conclusion, our findings enrich the understanding of ncRNAs in WAT metabolism and health regulation, as well as reveal the differences between SAT and VAT at the level of tsRNAs.

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“…Generally, fatty acids (FAs) can be divided into short-chain, medium-chain, long-chain, and very-long-chain FAs. According to the degree of unsaturation on the carbon chain, they are also divided into saturated FAs, monounsaturated FAs (containing one double bond), and polyunsaturated FAs (containing multiple double bonds) ( 6 , 7 ). As nutrition has developed, studies have found that FAs with double bonds in different positions have different nutritional value.…”

Section: The Protective Function Of N-3 Pufasmentioning

confidence: 99%

The function of omega-3 polyunsaturated fatty acids in response to cadmium exposure

Chen

Wang

et al. 2022

Front. Immunol.

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Throughout history, pollution has become a part of our daily life with the improvement of life quality and the advancement of industry and heavy industry. In recent years, the adverse effects of heavy metals, such as cadmium (Cd), on human health have been widely discussed, particularly on the immune system. Here, this review summarizes the available evidence on how Cd exposure may affect health. By analyzing the general manifestations of inflammation caused by Cd exposure, we find that the role of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) in vivo can counteract Cd-induced harm. Additionally, we elucidate the effects of n-3 PUFAs on the immune system, and analyze their prophylactic and therapeutic effects on Cd exposure. Overall, this review highlights the role of n-3 PUFAs in the pathological changes induced by Cd exposure. Although n-3 PUFAs remain to be verified whether they can be used as therapeutic agents, as rehabilitation therapy, supplementation with n-3 PUFAs is reliable and effective.

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circ01592 regulates unsaturated fatty acid metabolism through adsorbing miR-218 in bovine mammary epithelial cells

Abstract: The composition of fatty acids plays a key role in regulating milk flavor and quality. Therefore, to improve the quality of milk, it is particularly important to study the regulatory...

Cited by 14 publications

References 50 publications

The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation

The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation

tsRNA Landscape and Potential Function Network in Subcutaneous and Visceral Pig Adipose Tissue

The function of omega-3 polyunsaturated fatty acids in response to cadmium exposure

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