Circ_0001178 regulates miR-382/VEGFA axis to facilitate hepatocellular carcinoma progression

Gao, Shan; Hu, Wei; Huang, Xin; Huang, Xingyue; Chen, Wenwei; Hao, Li-dan; Chen, Zubing; Wang, Jian; Wei, Hailiang

doi:10.1016/j.cellsig.2020.109621

Cited by 22 publications

(16 citation statements)

References 30 publications

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“…MicroRNA‐382‐3p has dual functions, acting either as tumor suppressor or as oncogenic miRNA. On the one hand, miR‐382‐3p inhibits angiogenesis, proliferation, invasion and migration via targeting of VEGFA, EZH2, STAT1 and ZIC4 in various cancers 67,68 . But miR‐382‐3p is also a responsive miRNA of TGF‐β1, the well‐known inducer of EMT and chronic inflammation 69 .…”

Section: Discussionmentioning

confidence: 99%

Integrated bioinformatic analysis of dysregulated microRNA‐mRNA co‐expression network in ovarian endometriosis

Liu

Fan

Jin

et al. 2022

Acta Obstet Gynecol Scand

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Introduction:Ovarian endometriosis is a frequently occurring gynecological disease with large socioeconomic impact. Accumulating evidence has suggested that aberrant miRNA-mRNA interactions are involved in the pathogenesis and progression of ovarian endometriosis. This study aims to identify key miRNAs in ovarian endometriosis by using integrated bioinformatic analysis of a dysregulated miRNA-mRNA coexpression network.Material and methods: Expression profiling of miRNA and mRNA in three normal endometria and five pairs of ectopic/eutopic endometria from patients with ovarian endometriosis was determined by high-throughput sequencing techniques. The data were then integrated with the public sequencing datasets (GSE105764 and GSE105765) using a non-biased approach and a miRNA-mRNA co-expression regulatory network was constructed by in-depth bioinformatic analysis. Results:The constructed miRNA-mRNA network included 87 functionally DEMs, 482 target mRNAs and 1850 paired miRNA-mRNA regulatory interactions. Specifically, five miRNAs (miR-141-3p, miR-363-3p, miR-577, miR-767-5p, miR-96-5p) were gradually decreased and two miRNAs (miR-493-5p, miR-592) were gradually increased from normal endometria to eutopic endometria, and then ectopic endometria tissues.Importantly, miR-141-3p, miR-363-3p and miR-96-5p belonged to the miR-200 family, miR-106a-363 cluster and miR-183/96/182 cluster, respectively. Their target mRNAs were mainly associated with cell adhesion, locomotion and binding, which are suggested to play vital regulatory roles in the pathogenesis of ovarian endometriosis. Conclusions: Integrated bioinformatic analysis of the miRNA-mRNA co-expression network defines the crucial roles of the miR-200 family, miR-106a-363 cluster and miR-183/96/182 cluster in the pathogenesis of ovarian endometriosis. Further indepth functional studies are needed to unveil the molecular mechanisms of these | 1075 LIU et aL.

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Section: Discussionmentioning

confidence: 99%

Integrated bioinformatic analysis of dysregulated microRNA‐mRNA co‐expression network in ovarian endometriosis

Liu

Fan

Jin

et al. 2022

Acta Obstet Gynecol Scand

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“…They are a class of covalently closed continuous loops RNAs that can tolerate RNase R digestion so that they are considered better diagnostic markers than linear transcripts 39 . CircRNAs have been well characterized as hub genes, oncogenes or tumour suppressors in various diseases such as sciatic nerve injury, 15 Alzheimer's disease, 40 hepatocellular carcinoma, 16,41 and breast cancer 42 . However, little information has been noted between circRNAs and PE.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, studies have proved that circRNAs participate in various diseases 12,13 . Competing endogenous RNA (ceRNA) is one of the functional roles of circRNAs which is involved in the metastasis of the diseases 14‐16 . A circRNA functions as a miRNA sponge as it binds to the relevant miRNA and influences the generation of miRNAs that interact with their target mRNAs 14,17 .…”

Section: Introductionmentioning

confidence: 99%

Circular RNA VRK1 facilitates pre‐eclampsia progression via sponging miR‐221‐3P to regulate PTEN/Akt

Zhou

Gao

et al. 2021

J Cellular Molecular Medi

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Pre‐eclampsia (PE) is a worldwide pregnancy‐related disorder. It is mainly characterized by defect migration and invasion of trophoblast cells. Recently, circular RNAs (circRNAs) have been believed to play a vital role in PE. The expression patterns and the biological functions of circRNAs in PE remain elusive. Here, we performed a circRNA microarray to identify putative PE‐related circRNAs. Bioinformatics analyses were used to screen the circRNAs which have potential relationships with pre‐eclampsia, and we identified a novel circRNA (circVRK1) that was up‐regulated in PE placenta tissues. By using HTR‐8/SVneo cells, circVRK1 knockdown significantly enhanced cell migration and invasion abilities, as well as epithelial‐mesenchymal transition (EMT). Mechanistically, we found that circVRK1 and PTEN could function as the ceRNAs to miR‐221‐3p. Overexpression of miR‐221‐3p promoted cell migration, invasion and EMT via regulating PTEN. The cotransfection of miR‐221‐3p inhibitor or PTEN reversed the effect from circVRK1 knockdown. Moreover, the circVRK1/miR‐221‐3p/PTEN axis greatly regulated Akt phosphorylation. In general, circVRK1 suppresses trophoblast cell migration, invasion and EMT, by acting as a ceRNA to miR‐221‐3p to regulate PTEN, and further inhibit PI3K/Akt activation. The purpose of this paper is to open wide insights to investigate the onset of PE and provide new potential therapeutic targets in PE.

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“…Circ_0001178 is upregulated in hepatocellular carcinoma (HCC) and can directly bind to miR-382. VEGFA is a downstream target of miR-382, and it has been reported that circ_0001178 promotes liver cancer progression by regulating miR-382 and VEGFA; the knockdown of circ_0001178 inhibits HCC growth in vivo ( 72 ).…”

Section: Effects Of Circrnas On Tumor Angiogenesis In Various Systemsmentioning

confidence: 99%

Research progress on the circRNA‑mediated regulation of tumor angiogenesis through ceRNA mechanisms (Review)

et al. 2022

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Tumors are one of the most common fatal diseases worldwide and pose a severe threat to human health. Effective tumor prevention and treatment strategies are persistent challenges in the medical community. Angiogenesis plays a critical role in and is the basis for tumor development and metastasis. Circular RNAs (circRNAs) are novel single-stranded covalently closed RNA molecules that are widely expressed in tumors due to their structural specificity and conservation. circRNAs affect angiogenesis by functioning as microRNA sponges to regulate vascular endothelial growth factor-related pathways, thereby participating in various stages of tumor growth, invasion and proliferation. The present review summarizes the involvement of circRNAs in the regulation of tumor angiogenesis through competing endogenous RNA mechanisms, with a particular focus on the regulatory role of circRNAs in tumor angiogenesis in various systems. It is considered that circRNAs have great potential for use as tumor diagnostic markers and anti-angiogenic therapies, and are thus worthy of further research and exploration.

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Circ_0001178 regulates miR-382/VEGFA axis to facilitate hepatocellular carcinoma progression

Cited by 22 publications

References 30 publications

Integrated bioinformatic analysis of dysregulated microRNA‐mRNA co‐expression network in ovarian endometriosis

Integrated bioinformatic analysis of dysregulated microRNA‐mRNA co‐expression network in ovarian endometriosis

Circular RNA VRK1 facilitates pre‐eclampsia progression via sponging miR‐221‐3P to regulate PTEN/Akt

Research progress on the circRNA‑mediated regulation of tumor angiogenesis through ceRNA mechanisms (Review)

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