circ_0006089 promotes gastric cancer growth, metastasis, glycolysis, and angiogenesis by regulating miR‐361‐3p/TGFB1

Zhou, Ying; Zhang, Qilin; Liao, Bingling; Qiu, Xiaofeng; Hu, Sheng; Xu, Qingmei

doi:10.1111/cas.15351

Cited by 21 publications

(19 citation statements)

References 39 publications

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“…However, the question of whether and how the ceRNA participates in radiationinduced tumor angiogenesis and metastasis is unanswered. In addition, TGF-β1 is a kind of secreted protein that has been studied for many years, and it has been con rmed to participate in numerous cancer cell biological processes, including immune-suppressing, stemness, metastasis, angiogenesis, drug/radioresistance, and so on [63][64][65][66][67][68][69][70][71]. The function of TGF-β1 in radiation biology has also been explored.…”

Section: Discussionmentioning

confidence: 99%

Carbon ion irradiation suppresses angiogenic response in human lung adenocarcinoma cells mediated by LINC00167/miR-663a/TGF-β1 axis

Huang¹,

Xu²,

Guo³

et al. 2022

Preprint

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Background Radiotherapy plays an important role in numerous tumor clinical treatments and over 65% of cancer patients need to accept radiotherapy all over the world. However, tumor angiogenesis and metastasis induced by conventional photon radiotherapy adversely impact the survival of patients, and limit the clinical radiotherapy efficiency. Heavy-ion radiotherapy has attracted wide attention in recent years because of its excellent physical property and outstanding tumor control rate, however, the underlying gene expression regulation mechanism response to heavy-ion irradiation remains elusive. Methods RNA-sequencing (RNA-seq) and public database analysis were employed to identify the differential molecular changes in lung adenocarcinoma cells exposed to both X-ray and carbon ion (C-ion) irradiation. The expression of the identified LINC00167 was verified by real-time quantitative PCR in different lung cancer cell lines and pulmonary bronchial epithelial cell lines. The content of serum vascular endothelial growth factor (VEGF) and transforming growth factor beta 1 (TGF-β1) of 8 lung cancer patients who received X-ray or carbon ion radiotherapy were detected by ELISA experiment. Loss-of-function and gain-of-function experiments were performed to explore the biological roles of LINC00167 and miR-663a in lung cancer cell angiogenesis and metastasis. Comprehensive biochemical and biological techniques were utilized to explore the functions of LINC00167 in tumor angiogenesis and metastasis induced by different radiation types. Results In this study, we confirmed that LINC00167 was highly expressed and induced by X-ray irradiation in lung cancer cells. Moreover, increased LINC00167 expression was positively correlated with tumor angiogenesis and metastasis caused by conventional photon radiotherapy. LINC00167 worked as a sponge of miR-663a to positively regulate the expression of TGF-β1 and the downstream VEGF signaling and then promoted the tumor angiogenesis and metastasis of lung cancer cells. LINC00167 could strengthen the pro-angiogenesis and metastasis ability of lung cancer cells. Photon radiation-induced LINC00167 promoted angiogenesis both in vitro and in vivo. Conclusion Our data suggest that LINC00167/miR-663a/TGF-β1 axis is involved in the differential angiogenic response of lung adenocarcinoma cells exposed to X-ray or C-ion irradiation, providing the molecular mechanisms underlying the suppressed angiogenic response induced by carbon ion radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Carbon ion irradiation suppresses angiogenic response in human lung adenocarcinoma cells mediated by LINC00167/miR-663a/TGF-β1 axis

Huang¹,

Xu²,

Guo³

et al. 2022

Preprint

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“…It controls the innate and adaptive immune system by modulating the behaviors of T cells, NK cells, DCs, and macrophages, thus forming a negative immune regulatory network (Batlle & Massagué, 2019). Thus, cancer‐derived ncRNAs could promote TGF‐β generation to accelerate tumor progression, such as circ_0006089 (Y. Zhou, Zhang, et al, 2022). It was overexpressed in gastric cancer (GC) cells and tissues, and sponged miR‐361‐3p to promote TGF‐β1 production (Y. Zhou, Zhang, et al, 2022).…”

Section: Cancer‐derived Ncrnas and Immunuosuppressive Cytokine Sercetionmentioning

confidence: 99%

Cancer‐derived non‐coding RNAs endow tumor microenvironment with immunosuppressive properties

Hu,

Shi,

et al. 2023

WIREs RNA

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Non‐coding RNAs (ncRNAs) have attracted extensive attention due to their vital roles in tumorigenesis and progression, especially in the immunotherapy resistance. Tumor immunotherapy resistance is a crucial factor hindering the efficacy of tumor treatments, which can be largely attributed to the immunosuppressive properties of tumor microenvironment. Current studies have revealed that cancer‐derived ncRNAs are involved in the formation of tumor immunosuppressive microenvironment (TIME) through multiple ways. They not only promote the expression of immune checkpoint ligands (e.g., PD‐L1, CD47, Gal‐9, and CD276) on cancer cell surfaces, but also enhance the secretion of immunosuppressive cytokines (e.g., TGF‐β, IL‐6, IL‐10, VEGF, and chemokines). Cancer‐derived ncRNAs could also be transferred into surrounding immune‐related cells through extracellular vesicles, thereby inhibiting the cytotoxicity of CD8+T cells and NK cells, restraining the DC‐mediated antigen presentation, inducing the immunosuppressive phenotype transformation of TAMs and CAFs, and enhancing the immunosuppressive functions of Tregs and MDSCs. Herein, we summarize the roles of cancer‐derived ncRNAs in regulating TIME formation and further explore their potential applications as prognostic biomarkers and immunotherapeutic targets, which will help us to address the TIME‐mediated immunotherapy resistance in the future.This article is categorized under: RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs

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“…CircNRIP1 can activate AKT1/mTOR pathway by sponging miRNA-149-5p [52], circRNA-100290 up-regulates EMT-related oncogene ITGA11 by sponging miR-29b-3p [53], circ-0032821 can regulate miR-1236-3p/HMGB1 axis [54], and circ_0005529 up-regulates SP1 by sponging miR-527 [55], thus promoting the proliferation, EMT, migration and invasion of GC cells. Circ-OXCT1 suppresses EMT and metastasis by attenuating the TGF-beta pathway through the circ-OXCT1/miR-136/SMAD4 axis [56], circRNA-0005075 suppresses carcinogenesis via regulating miR-431/p53/EMT [57], circ_0006089 promotes gastric cancer growth, metastasis, glycolysis, and angiogenesis by regulating miR-361-3p/TGFB1 [58], hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis [59], the circular RNA, circ_0006089, also regulates the IGF1R expression by targeting miR-143-3p to promote gastric cancer proliferation, migration, and invasion [60], the overexpression of circ_0051620 is associated with progress and poor prognosis of GC, promoting the development and metastasis via sponging miR-338-3p and decoying ADAM17 [61], and circFGD4 can inactivate β -catenin signal through miR-532-3p/APC pathway to inhibit the activity, migration, and EMT of GC cells [62].…”

Section: Circrna-associated Cerna Network In Gastric Carcinomamentioning

confidence: 99%

Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR

Guo

Jia

Luo

et al. 2022

IJMS

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Circular RNAs (circRNAs), a class of new endogenous non-coding RNAs (ncRNAs), are closely related to the carcinogenic process and play a critical role in tumor metastasis. CircRNAs can lay the foundation for tumor metastasis via promoting tumor angiogenesis, make tumor cells gain the ability of migration and invasion by regulating epithelial-mesenchymal transition (EMT), interact with immune cells, cytokines, chemokines, and other non-cellular components in the tumor microenvironment, damage the normal immune function or escape the immunosuppressive network, and further promote cell survival and metastasis. Herein, based on the characteristics and biological functions of circRNA, we elaborated on the effect of circRNA via circRNA-associated competing endogenous RNA (ceRNA) network by acting as miRNA/isomiR sponges on tumor angiogenesis, cancer cell migration and invasion, and interaction with the tumor microenvironment (TME), then explored the potential interactions across different RNAs, and finally discussed the potential clinical value and application as a promising biomarker. These results provide a theoretical basis for the further application of metastasis-related circRNAs in cancer treatment. In summary, we briefly summarize the diverse roles of a circRNA-associated ceRNA network in cancer metastasis and the potential clinical application, especially the interaction of circRNA and miRNA/isomiR, which may complicate the RNA regulatory network and which will contribute to a novel insight into circRNA in the future.

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circ_0006089 promotes gastric cancer growth, metastasis, glycolysis, and angiogenesis by regulating miR‐361‐3p/TGFB1

Cited by 21 publications

References 39 publications

Carbon ion irradiation suppresses angiogenic response in human lung adenocarcinoma cells mediated by LINC00167/miR-663a/TGF-β1 axis

Carbon ion irradiation suppresses angiogenic response in human lung adenocarcinoma cells mediated by LINC00167/miR-663a/TGF-β1 axis

Cancer‐derived non‐coding RNAs endow tumor microenvironment with immunosuppressive properties

Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR

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