Circ_0006404 Accelerates Prostate Cancer Progression Through Regulating miR-1299/CFL2 Signaling

Li, Peihuan; Wang, Zhijie; Li, Shuai; Wang, Liuxing

doi:10.2147/ott.s277831

Cited by 26 publications

(17 citation statements)

References 30 publications

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“…Circ_0006404 was shown to exhibit a higher level in PCa specimens than non-tumor specimens. Functional investigations revealed its overexpression displayed a positive role in the progression of tumor growth and metastasis via modulating miR-1299/CFL2 axis ( Li et al, 2021 ). These findings highlighted the important effects of circRNAs on tumor developments.…”

Section: Discussionmentioning

confidence: 99%

Hsa_circRNA_100146 Promotes Prostate Cancer Progression by Upregulating TRIP13 via Sponging miR-615-5p

Zeng

Liu

Yang

et al. 2021

Front. Mol. Biosci.

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Objective: This study was conducted for investigating the functions of circular RNA circRNA_100146 (circRNA_100146) in the development of prostate cancer (PCa) and identifying the underlying mechanisms of the circRNA_100146/miR-615-5p/TRIP13 axis.Materials and Methods: Under the support of RT-PCR, the expression of circRNA_100146 in PCa cells was examined. Cell Counting Kit-8 (CCK-8) assays and clone formation assays were applied to the assessment of cell proliferation. We then determined cell invasion and migration through transwell assays and wound healing assays. RNA pull-down assays and luciferase reporter assays were performed for the exploration of the regulatory effects of potential molecules on the expressions of the targeting genes. In addition, a nude mouse xenograft model was applied to demonstrate the oncogenic roles of circRNA_100146 in PCa.Results: CircRNA_100146 expression was distinctly upregulated in PCa cells. Silencing of circRNA_100146 suppressed PCa cells’ invasion, migration, and proliferation. CircRNA_100146 sponged miR-615-5p to suppress its expressions, while miR-615-5p targeted the 3’-UTR of TRIP13 to repress the expression of TRIP13. In addition, we observed that knockdown of miR-615-5p reversed the suppression of circRNA_100146 silence on the proliferation and invasion of PCa cells. In addition, the tumor growth was also suppressed by silencing circRNA_100146 in vivo.Conclusion: CircRNA_100146 is a tumor promoter in PCa, which promoted progression by mediating the miR-615-5p/TRIP13. CircRNA_100146 can be a potential candidate for targeted therapy of PCa.

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Section: Discussionmentioning

confidence: 99%

Hsa_circRNA_100146 Promotes Prostate Cancer Progression by Upregulating TRIP13 via Sponging miR-615-5p

Zeng

Liu

Yang

et al. 2021

Front. Mol. Biosci.

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“…Circ-0016068 up-regulation facilitated the growth and metastasis of PCa via sequestering miR-330-3p to activate BMI-1 . Circ_0006404 aggravated the deterioration of PCa through competitively binding to miR-1299 and increasing CFL2 expression (Li et al, 2021). Besides, Huang et al discovered that circSLC19A1 (circ_0062019) contributed to PCa cell progression by decoying miR-326 and elevating MAPK1 (Huang et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Circular RNA circ_0062019 exerts oncogenic properties in prostate cancer via mediating miR‐1253/NRBP1 axis

et al. 2021

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ing to 2018 statistics, the incidence of prostate cancer continues to rise, ranking fifth among male cancers (Bray et al., 2018). Despite PCa treatment has made significant progress, advanced PCa still imposes a huge social and economic burden (Cassell et al., 2019).Consequently, exploring new potential biomarkers is essential to discover new treatment strategies for prostate cancer. Circular RNAs (circRNAs) are single-stranded endogenous molecules constructed by back-splicing (Li et al., 2020). CircRNAs with high stability are aberrantly expressed in different diseases and hold great potential as cancer biomarkers (Tang & Hann, 2020). Synchronously, circRNAs are implicated in regulating various biological processes in PCa (Wu et al., 2020). For example, circ_0088233 was prominently boosted in PCa tissues through circRNA microarray detection and exerted oncogenic properties in PCa (Deng et al., 2020).Furthermore, interference of circ-ZNF609 impeded tumour metastasis and increased radiosensitivity in PCa via repressing glycolysis (Du et al., 2020). Also, low levels of circular RNA_LARP4 had apparent correlation with the poor prognosis of PCa patients, and its overexpression alleviated the malignant progression of PCa via combining with FOXO3A (Weng et al., 2020). Besides, prior research revealed that circ_0062019 produced by SLC19A1 gene was conspicuously up-regulated in PCa (Xia et al., 2018). Nevertheless, the mechanism underlying circ_0062019 in PCa needs further inquiry.In terms of circRNAs biological functions, circRNAs block the binding of microRNAs (miRNAs) to downstream target genes through functioning as miRNA sponges (Zhong et al., 2018). For

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“…It was reported that circFOXO3 was up-regulated in PCa tissues and serum samples and played a tumor-promoting role (Kong et al, 2020;Li et al, 2021). Moreover, Li et al (2021) proved that circFOXO3 was stable in PCa through RNase R digestion and Actinomycin D exposure. Silencing circFOXO3 could significantly inhibit the development of PCa in many aspects.…”

Section: The Roles Of Circfoxo3 In Cancers (Figure 2 and Table 1) Prostate Cancermentioning

confidence: 93%

“…For example, knockdown of circFOXO3 affected the normal cell cycle of PCa cells and reduced cell viability, thereby inhibiting tumor proliferation and invasion. At the same time, the apoptosis rate of tumor cells increased, reflecting the effect of circFOXO3 in inhibiting the apoptosis of PCa cells (Kong et al, 2020;Li et al, 2021). Interestingly, they found different mechanisms by which circFOXO3 promoted the development of PCa.…”

Section: The Roles Of Circfoxo3 In Cancers (Figure 2 and Table 1) Prostate Cancermentioning

confidence: 98%

“…First, circFOXO3 could target miR-29a-3p in PCa cells and enhance the expression level of SLC25A15 (Kong et al, 2020). Li et al (2021) demonstrated that circFOXO3 acted as a miR-1299 sponge to up-regulate the expression of cofilin 2, thus showing carcinogenic activity. In addition, Shen et al (2020) stated contradictory research conclusion.…”

Section: The Roles Of Circfoxo3 In Cancers (Figure 2 and Table 1) Prostate Cancermentioning

confidence: 99%

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The Emerging Roles of circFOXO3 in Cancer

Rao

Sheng

et al. 2021

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs which are mainly formed by reverse splicing of precursor mRNAs. They are relatively stable and resistant to RNase R because of their covalently closed structure without 5’ caps or 3’ poly-adenylated tails. CircRNAs are widely expressed in eukaryotic cells and show tissue, timing, and disease specificity. Recent studies have found that circRNAs play an important role in many diseases. In particular, they affect the proliferation, invasion and prognosis of cancer by regulating gene expression. CircRNA Forkhead box O3 (circFOXO3) is a circRNA confirmed to be abnormally expressed in a variety of cancers, including prostate cancer, hepatocellular carcinoma, glioblastoma, bladder cancer, and breast cancer, etc. At present, the feature of circFOXO3 as a molecular sponge is widely studied to promote or inhibit the development of cancers. However, the diverse functions of circFOXO3 have not been fully understood. Hence, it is important to review the roles of circFOXO3 in cancers. This review has summarized and discussed the roles and molecular mechanism of circFOXO3 and its target genes in these cancers, which can help to enrich our understanding to the functions of circRNAs and carry out subsequent researches on circFOXO3.

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Circ_0006404 Accelerates Prostate Cancer Progression Through Regulating miR-1299/CFL2 Signaling

Cited by 26 publications

References 30 publications

Hsa_circRNA_100146 Promotes Prostate Cancer Progression by Upregulating TRIP13 via Sponging miR-615-5p

Hsa_circRNA_100146 Promotes Prostate Cancer Progression by Upregulating TRIP13 via Sponging miR-615-5p

Circular RNA circ_0062019 exerts oncogenic properties in prostate cancer via mediating miR‐1253/NRBP1 axis

The Emerging Roles of circFOXO3 in Cancer

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