Circular RNA circ_0062019 exerts oncogenic properties in prostate cancer via mediating miR‐1253/NRBP1 axis

Ren, Xiaojun; Cheng, Jiyan; Zhu, Min; Chen, Xiao; Jiang, Min; Hu, X.; Lu, Yanan

doi:10.1111/and.14343

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…A study found that circ0062019 is highly expressed in PCa tissue and multiple PCa cell lines [ 173 ]. Knockdown of circ0062019 inhibits the proliferation and the cell cycle of PCa cells, promoting cellular apoptosis.…”

Section: Expression and Biological Function Of Circrnas In Urinary Sy...mentioning

confidence: 99%

The function and mechanisms of action of circular RNAs in Urologic Cancer

et al. 2023

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Kidney, bladder, and prostate cancer are the three major tumor types of the urologic system that seriously threaten human health. Circular RNAs (CircRNAs), special non-coding RNAs with a stabile structure and a unique back-splicing loop-forming ability, have received recent scientific attention. CircRNAs are widely distributed within the body, with important biologic functions such as sponges for microRNAs, as RNA binding proteins, and as templates for regulation of transcription and protein translation. The abnormal expression of circRNAs in vivo is significantly associated with the development of urologic tumors. CircRNAs have now emerged as potential biomarkers for the diagnosis and prognosis of urologic tumors, as well as targets for the development of new therapies. Although we have gained a better understanding of circRNA, there are still many questions to be answered. In this review, we summarize the properties of circRNAs and detail their function, focusing on the effects of circRNA on proliferation, metastasis, apoptosis, metabolism, and drug resistance in kidney, bladder, and prostate cancers.

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Section: Expression and Biological Function Of Circrnas In Urinary Sy...mentioning

confidence: 99%

The function and mechanisms of action of circular RNAs in Urologic Cancer

et al. 2023

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“…Therefore, the circRNA/EMT axis is a regulator of prostate cancer invasion. The delineation of molecular pathways that can be targeted for treatment of this malignant disease warrants further research [ 217 , 218 ].…”

Section: Circrna/emt Axis In Different Cancersmentioning

confidence: 99%

Circular RNAs in EMT-driven metastasis regulation: modulation of cancer cell plasticity, tumorigenesis and therapy resistance

Ashrafizadeh,

Dai,

Torabian

et al. 2024

Cell. Mol. Life Sci.

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The non-coding RNAs comprise a large part of human genome lack of capacity in encoding functional proteins. Among various members of non-coding RNAs, the circular RNAs (circRNAs) have been of importance in the pathogenesis of human diseases, especially cancer. The circRNAs have a unique closed loop structure and due to their stability, they are potential diagnostic and prognostic factors in cancer. The increasing evidences have highlighted the role of circRNAs in the modulation of proliferation and metastasis of cancer cells. On the other hand, metastasis has been responsible for up to 90% of cancer-related deaths in patients, requiring more investigation regarding the underlying mechanisms modulating this mechanism. EMT enhances metastasis and invasion of tumor cells, and can trigger resistance to therapy. The cells demonstrate dynamic changes during EMT including transformation from epithelial phenotype into mesenchymal phenotype and increase in N-cadherin and vimentin levels. The process of EMT is reversible and its reprogramming can disrupt the progression of tumor cells. The aim of current review is to understanding the interaction of circRNAs and EMT in human cancers and such interaction is beyond the regulation of cancer metastasis and can affect the response of tumor cells to chemotherapy and radiotherapy. The onco-suppressor circRNAs inhibit EMT, while the tumor-promoting circRNAs mediate EMT for acceleration of carcinogenesis. Moreover, the EMT-inducing transcription factors can be controlled by circRNAs in different human tumors.

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Cellular senescence: A potential mode of circular RNAs regulating prostate cancer

Li,

Fan,

Zhang

et al. 2023

MedComm – Oncology

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Cellular senescence is a state characterized by permanent cell cycle stoppage, which has long been viewed as a protective mechanism against neoplasia. However, accumulating evidence reveal that cellular senescence variously stimulates tumorigenesis and malignant progression in certain contexts. Senescence‐associated secretory phenotype (SASP) is a crucial feature of senescent cells and the main way they function. Prostate cancer (PCa) is apparently an age‐related tumor with a high prevalence in the elderly. With the aggravation of population aging the morbidity of PCa continues to rise. And with the progress of the disease, most patients eventually develop castration‐resistant PCa (CRPC) or drug resistance, which poses a challenge for the treatment of PCa and aggravates the burden on patients and society. Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs formed by back‐splicing of pre‐mRNAs. Characterized by special covalently closed circular structure, they play important regulatory roles in various tumors. Numerous studies have revealed that circRNAs can regulate PCa and cellular senescence in diverse ways. This review explores a potential mode that circRNAs regulate PCa, reveales a significant mechanism of tumorigenesis and progression for PCa, suggesting a new strategy for PCa research.

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Circular RNA circ_0062019 exerts oncogenic properties in prostate cancer via mediating miR‐1253/NRBP1 axis

Cited by 7 publications

References 30 publications

The function and mechanisms of action of circular RNAs in Urologic Cancer

The function and mechanisms of action of circular RNAs in Urologic Cancer

Circular RNAs in EMT-driven metastasis regulation: modulation of cancer cell plasticity, tumorigenesis and therapy resistance

Cellular senescence: A potential mode of circular RNAs regulating prostate cancer

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