Circ_0091579 exerts an oncogenic role in hepatocellular carcinoma via mediating miR-136-5p/TRIM27

Mao, Yantao; Ding, Zhigang; Jiang, Maozhu; Yuan, Bo; Zhang, Yao; Zhang, Xiaobin

doi:10.1016/j.bj.2021.12.009

Cited by 15 publications

(9 citation statements)

References 47 publications

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“…Furthermore, circRNAs can act as sponges of miRNAs to repress miRNA function. Circ_0091579 acts as a sponge of miR-136-5p to up-regulate TRIM27 [ 56 ]. Circular RNA PVT1 (CircPVT1) acts as a sponge of miR-377 to up-regulate TRIM23 and promote HCC [ 57 ].…”

Section: Expression Pattern and Biological Functions Of Trim Proteins...mentioning

confidence: 99%

TRIM proteins in hepatocellular carcinoma

Pan

Huang

et al. 2022

J Biomed Sci

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The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain. Generally, TRIM proteins function as E3 ligases to facilitate specific proteasomal degradation of target proteins. In addition, E3 ligase independent functions of TRIM protein were also reported. In hepatocellular carcinoma, expressions of TRIM proteins are both regulated by genetic and epigenetic mechanisms. TRIM proteins regulate multiple biological activities and signaling cascades. And TRIM proteins influence hallmarks of HCC. This review systematically demonstrates the versatile roles of TRIM proteins in HCC and helps us better understand the molecular mechanism of the development and progression of HCC.

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Section: Expression Pattern and Biological Functions Of Trim Proteins...mentioning

confidence: 99%

TRIM proteins in hepatocellular carcinoma

Pan

Huang

et al. 2022

J Biomed Sci

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“…Similarly, some circRNAs have been concerned because of their roles in liver cancer via sponging flexible regulators, miRNAs. Specifically, knockdown of circ-CSPP1 can suppress HCC development both in vitro and in vivo by upregulation of miR-493-5p and downregulation of HMGB1 [75], circ-CCND1 plays a cancer-promoting role by modulating the miR-497-5p/HMGA2 axis [76], circPUM1 could promote the development of HCC by up-regulating the expression of MAP3K2 via sponging miR-1208 [77], circRNA-5692 can sponge miR-328-5p to enhance DAB2IP expression, and the circRNA-5692-miR-328-5p-DAB2IP regulatory pathway inhibits the progression of HCC [78], circ_CDR1as up-regulates RAF1 expression via targeting miR-1287 and further regulates EMT pathway through MEK/ERK [79], circ_0091579 up-regulates the expression of TRIM27 by acting as a molecular sponge of miR-136-5p [80], and hsa_circ_0003288 enhances the expression of PD-L1 by acting as a sponge of miR-145 to promote EMT [81], migration and invasion of HCC cells, circ_0008194 acts as a sponge of miR-190a to promote AHNAK expression [82], and all of these promote EMT process and HCC proliferation and migration. In addition, circHPS5 upregulates the expression of HMGA2 by acting as a miR-370 sponge, thus accelerating the occurrence and proliferation of HCC tumors and promoting the migration of cancer cells through the EMT pathway.…”

Section: Circrna-associated Cerna Network In Liver Cancermentioning

confidence: 99%

Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR

Guo

Jia

Luo

et al. 2022

IJMS

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Circular RNAs (circRNAs), a class of new endogenous non-coding RNAs (ncRNAs), are closely related to the carcinogenic process and play a critical role in tumor metastasis. CircRNAs can lay the foundation for tumor metastasis via promoting tumor angiogenesis, make tumor cells gain the ability of migration and invasion by regulating epithelial-mesenchymal transition (EMT), interact with immune cells, cytokines, chemokines, and other non-cellular components in the tumor microenvironment, damage the normal immune function or escape the immunosuppressive network, and further promote cell survival and metastasis. Herein, based on the characteristics and biological functions of circRNA, we elaborated on the effect of circRNA via circRNA-associated competing endogenous RNA (ceRNA) network by acting as miRNA/isomiR sponges on tumor angiogenesis, cancer cell migration and invasion, and interaction with the tumor microenvironment (TME), then explored the potential interactions across different RNAs, and finally discussed the potential clinical value and application as a promising biomarker. These results provide a theoretical basis for the further application of metastasis-related circRNAs in cancer treatment. In summary, we briefly summarize the diverse roles of a circRNA-associated ceRNA network in cancer metastasis and the potential clinical application, especially the interaction of circRNA and miRNA/isomiR, which may complicate the RNA regulatory network and which will contribute to a novel insight into circRNA in the future.

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“…At the same time, the overexpression of TRIM27 largely attenuated the influence of miR-136-5p in HCC cells. To sum up, Circ_0091579 could promote the proliferation and migration of HCC cells via the miR-136-5p/TRIM27 axis ( Mao et al, 2021 ).…”

Section: Role Of Trim27 In Cancermentioning

confidence: 99%

Emerging roles of TRIM27 in cancer and other human diseases

Rao²,

Wang³

et al. 2022

Front. Cell Dev. Biol.

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As a member of the TRIM protein family, TRIM27 is a RING-mediated E3 ubiquitin ligase that can mark other proteins for degradation. Its ubiquitination targets include PTEN, IκBα and p53, which allows it to regulate many signaling pathways to exert its functions under both physiological and pathological conditions, such as cell proliferation, differentiation and apoptosis. During the past decades, TRIM27 was reported to be involved in many diseases, including cancer, lupus nephritis, ischemia-reperfusion injury and Parkinson’s disease. Although the research interest in TRIM27 is increasing, there are few reviews about the diverse roles of this protein. Here, we systematically review the roles of TRIM27 in cancer and other human diseases. Firstly, we introduce the biological functions of TRIM27. Next, we focus on the roles of TRIM27 in cancer, including ovarian cancer, breast cancer and lung cancer. At the same time, we also describe the roles of TRIM27 in other human diseases, such as lupus nephritis, ischemia-reperfusion injury and Parkinson’s disease. Finally, we discuss the future directions of TRIM27 research, especially its potential roles in tumor immunity.

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Circ_0091579 exerts an oncogenic role in hepatocellular carcinoma via mediating miR-136-5p/TRIM27

Cited by 15 publications

References 47 publications

TRIM proteins in hepatocellular carcinoma

TRIM proteins in hepatocellular carcinoma

Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR

Emerging roles of TRIM27 in cancer and other human diseases

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