circ_100984‐miR‐432‐3p axis regulated c‐Jun/YBX‐1/β‐catenin feedback loop promotes bladder cancer progression

Liang, Tong; Yang, Huihui; Wang, Xiong; Tang, Guyu; Zu, Xiongbing; Lin, Qi

doi:10.1111/cas.14774

Cited by 23 publications

(12 citation statements)

References 45 publications

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“…CircRNA-SORE binds to the YB-1 protein in the cytoplasm, blocks E3 ubiquitin ligase precursor mRNA processing factor 19 (PRP19)-mediated YB-1 ubiquitination and degradation, and ultimately promotes sorafenib resistance in hepatocellular carcinoma [ 145 ]. Circ_100984 indirectly promotes YB-1 expression and EMT by binding to miR-432-3p, promoting breast cancer progression [ 146 ]. Similarly, circ-SAR1A upregulates the expression of YB-1 by acting as a sponge of miR-382 to promote the growth and invasion of renal cell carcinoma cells [ 147 ].…”

Section: Upstream Regulation Of Yb-1mentioning

confidence: 99%

YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy

Yin

Zheng

Luo

et al. 2022

Cells

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Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD) that also belongs to the family of DNA- and RNA-binding proteins. YB-1 is present in both the nucleus and cytoplasm and plays versatile roles in gene transcription, RNA splicing, DNA damage repair, cell cycle progression, and immunity. Cumulative evidence suggests that YB-1 promotes the progression of multiple tumor types and serves as a potential tumor biomarker and therapeutic target. This review comprehensively summarizes the emerging functions, mechanisms, and regulation of YB-1 in cancers, and further discusses targeted strategies.

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Section: Upstream Regulation Of Yb-1mentioning

confidence: 99%

YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy

Yin

Zheng

Luo

et al. 2022

Cells

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“…Collectively, upregulation of circRIMS1 expression could facilitate EMT in BCa. In vitro studies supported a relationship between dysregulated circRNAs and EMT in BCa, including circ0006332, circMTO1, circ5912, circFUT8, circ100984, and circRBPMS, along with upregulation of mesenchymal marker expression, including N-cadherin and vimentin ( Li et al, 2019a ; Li Y. et al, 2019 ; Su et al, 2019a ; He Q. et al, 2020 ; Tong et al, 2020 ; Yang et al, 2021 ). These findings demonstrate that circRNAs may be therapeutic targets, and the development of tools such as CircInteractome ( Dudekula et al, 2016 ) has improved the potential to develop siRNAs that are able to selectively inhibit circRNAs of interest.…”

Section: Circular Rnas and Bladder Cancermentioning

confidence: 78%

“…Mounting evidence revealed that circRNAs can also play an oncogenic role in promoting invasion and metastasis of BCa cells. For instance, circ100984 was found to be highly expressed in BCa ( Tong et al, 2020 ). Silencing circ100984 repressed BCa cell viability, invasion, and migration both in vitro and in vivo .…”

Section: Circular Rnas and Bladder Cancermentioning

confidence: 99%

The Roles of CircRNAs in Bladder Cancer: Biomarkers, Tumorigenesis Drivers, and Therapeutic Targets

Cheng

Zheng

et al. 2021

Front. Cell Dev. Biol.

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Bladder cancer (BCa) is the most prevalent malignancy of the urinary system. Circular RNAs (circRNAs), a novel subtype of non-coding RNAs, play a crucial role in physiological and developmental processes. CircRNAs mainly function as regulators of splicing process and transcription, microRNA sponges, and protein brackets. Recent advances in understanding the pathogenesis of BCa have led to the identification of an abundance of dysregulated circRNAs associated with BCa. These aberrantly expressed circRNAs eventually lead to abnormalities in biological, genetic, and epigenetic information. In this review, we introduce the potential of circRNAs as biomarkers for BCa diagnosis and prognosis. Notably, diverse mechanisms have been proposed for circRNAs driving carcinogenesis, including increasing cell proliferation, promoting invasive and migratory capacity, enhancing endothelial–mesenchymal transition, sustaining stemness, and enabling resistance to chemotherapy. Importantly, a full understanding of circRNA mechanisms is needed to mine promising therapeutic approaches for targeting BCa. In this paper, we present the latest advances in circRNAs and systemically summarize the characteristics and mechanisms of circRNAs in BCa, providing potential perspectives for BCa treatment.

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“…Consistent with our study, knockdown of EFEMP2 in BCa cells triggered reduction in the epithelial marker E-cadherin expression, as well as increase in mesenchymal markers N-cadherin, Snail and Slug, which is associated with augmented cell proliferative, migratory and metastatic capacities [ 22 ]. Depletion of circ_100984 retards the BCa tumor growth and migratory and invasive capacities in vitro and in vivo by inhibiting expression of EMT markers [ 23 ]. Our in vivo experiments also demonstrated that circ_0000658 increased the tumor volume and weight, which promotes the tumorigenesis of BCa cells.…”

Section: Discussionmentioning

confidence: 99%

Circ_0000658 knockdown inhibits epithelial-mesenchymal transition in bladder cancer via miR-498-induced HMGA2 downregulation

Qiu

Liu

Xia

et al. 2022

J Exp Clin Cancer Res

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Background Epithelial-mesenchymal transition (EMT) has been associated with the angiogenesis and oncogenic phenotypes of multiple malignant tumors including bladder cancer (BCa). Circular RNAs (circRNAs) are recognized as crucial regulators in the EMT. This study aims to illustrate the possible role of circular RNA_0000658 (circ_0000658) in BCa and the underlying molecular mechanism. Methods The expression of circ_0000658, microRNA (miR)-498, and high mobility group AT-hook 2 (HMGA2) was assessed in cancer and adjacent normal tissue collected from BCa patients and human BCa cell lines (MGH-U3, T24, 5637 and SW780). BCa cells were transduced with a series of overexpression or shRNA plasmids to clarify the function of circ_0000658 and miR-498 on the oncogenic phenotypes and EMT of BCa cells. Further, we established nude mice xenografted with BCa cells to validate the roles of circ_0000658 on tumor growth in vivo. Results Circ_0000658 was highly expressed in BCa tissue samples and cell lines, which indicated a poor prognosis of BCa patients. Circ_0000658 competitively bound to miR-498 and thus restricted miR-498 expression. Meanwhile, circ_0000658 weakened the binding of miR-498 to the target gene HMGA2 and upregulated the HMGA2 expression. Circ_0000658 elevation or miR-498 knockdown augmented oncogenic phenotypes and EMT of BCa cells, corresponding to a reduction in the expression of β-catenin and E-cadherin as well as an increase in the expression of N-cadherin, Slug, Snail, ZEB1 and Twist. Inhibition of HMGA2 reversed the effects of circ_0000658 overexpression on tumor growth in vivo. Conclusion Altogether, our study uncovered the tumor-promoting role of circ_0000658 in BCa via the miR-498/HMGA2 axis.

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circ_100984‐miR‐432‐3p axis regulated c‐Jun/YBX‐1/β‐catenin feedback loop promotes bladder cancer progression

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 23 publications

References 45 publications

YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy

YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy

The Roles of CircRNAs in Bladder Cancer: Biomarkers, Tumorigenesis Drivers, and Therapeutic Targets

Circ_0000658 knockdown inhibits epithelial-mesenchymal transition in bladder cancer via miR-498-induced HMGA2 downregulation

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