Circadian Disruption in Night Shift Work and Its Association with Chronic Pulmonary Diseases

Joshi, Arun; Sundar, Isaac K.

doi:10.1002/adbi.202200292

Cited by 4 publications

(4 citation statements)

References 119 publications

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“…In addition, shift work, especially night shift work, was shown to be associated with a higher risk of chronic physical disorders, including diabetes, cardiovascular disease, and cancer [1,40]. Consistent with the findings of previous studies [41][42][43], current results also suggested that shift work was significantly associated with an increased risk of poor health outcomes among the general population in China.…”

Section: Discussionsupporting

confidence: 90%

Association between Shift Work and Health Outcomes in the General Population in China: A Cross-Sectional Study

Gao,

Zheng,

Yang

et al. 2024

Brain Sciences

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Shift work may adversely affect individuals’ health, thus, the current study aimed to investigate the association between shift work and health outcomes in the general population. A total of 41,061 participants were included in this online cross-sectional survey, among which 9612 (23.4%) individuals engaged in shift work and 31,449 (76.6%) individuals engaged in non-shift work. Multiple logistic regression analyses were conducted to explore the association between shift work and health outcomes (psychiatric disorders, mental health symptoms, and physical disorders). In addition, associations between the duration (≤1 year, 1–3 years, 3–5 years, 5–10 years, ≥10 years) and frequency of shift work (<1 or ≥1 night/week) and health outcomes were also explored. The results showed that compared to non-shift workers, shift workers had a higher likelihood of any psychiatric disorders (odds ratios [OR] = 1.80, 95% CI = 1.56–2.09, p < 0.001), mental health symptoms (OR = 1.76, 95% CI = 1.68–1.85, p < 0.001), and physical disorders (OR = 1.48, 95% CI = 1.39–1.57, p < 0.001). In addition, inverted U-shaped associations were observed between the duration of shift work and health outcomes. These results indicated that shift work was closely related to potential links with poor health outcomes. The findings highlighted the importance of paying attention to the health conditions of shift workers and the necessity of implementing comprehensive protective measures for shift workers to reduce the impact of shift work.

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Section: Discussionsupporting

confidence: 90%

Association between Shift Work and Health Outcomes in the General Population in China: A Cross-Sectional Study

Gao,

Zheng,

Yang

et al. 2024

Brain Sciences

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“…There are several potential mechanisms underlying the associations between night shift work and COPD risk. Night shifts may trigger circadian disruption, resulting from the mismatch between internal circadian rhythms and external environmental conditions [40]. Subsequently, the changes in sleep-wake cycles and exposure to light-dark patterns can lead to abnormal levels of cortisol, melatonin, and body temperature, which have been associated with COPD [40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

“…Night shifts may trigger circadian disruption, resulting from the mismatch between internal circadian rhythms and external environmental conditions [40]. Subsequently, the changes in sleep-wake cycles and exposure to light-dark patterns can lead to abnormal levels of cortisol, melatonin, and body temperature, which have been associated with COPD [40][41][42][43]. For example, the night shift can alter the circadian rhythm, which has been reported to suppress melatonin biosynthesis [15,44,45].…”

Section: Discussionmentioning

confidence: 99%

Associations between long-term night shift work and incidence of chronic obstructive pulmonary disease: a prospective cohort study of 277,059 UK Biobank participants

Li,

Yang,

Yao

et al. 2024

BMC Med

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Background Little is known about the effects of night shifts and their interactions with genetic factors on chronic obstructive pulmonary disease (COPD). In this study, we aim to investigate relationships between long-term night shift work exposure and COPD risk, and assess modification effects of genetic predisposition. Methods A total of 277,059 subjects who were in paid employment or self-employed were included in the UK Biobank. Information on current and lifetime employment was obtained, and a weighted COPD-specific genetic risk score (GRS) was constructed. We used Cox proportional hazard models to investigate associations between night shift work and COPD risk, and their interaction with COPD-specific GRS. Results The cohort study included 277,059 participants (133,063 men [48.03%]; mean [SD] age, 52.71 [7.08] years). During a median follow-up of 12.87 years, we documented 6558 incidents of COPD. From day work, irregular night shifts to regular night shifts, there was an increased trend in COPD incidence (P for trend < 0.001). Compared with day workers, the hazard ratio (HR) and 95% confidence interval (CI) of COPD was 1.28 (1.20, 1.37) for subjects with rarely/sometimes night shifts and 1.49 (1.35, 1.66) for those with permanent night shifts. Besides, the longer durations (especially in subjects with night shifts ≥ 10 years) and increasing monthly frequency of night shifts (in workers with > 8 nights/month) were associated with a higher COPD risk. Additionally, there was an additive interaction between night shifts and genetic susceptibility on the COPD risk. Subjects with permanent night shifts and high genetic risk had the highest risk of COPD (HR: 1.90 [95% CI: 1.63, 2.22]), with day workers with low genetic risk as a reference. Conclusions Long-term night shift exposure is associated with a higher risk of COPD. Our findings suggest that decreasing the frequency and duration of night shifts may offer a promising approach to mitigating respiratory disease incidence in night shift workers, particularly in light of individual susceptibility.

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“…Altered production of some reactive species had been observed at an early stage of the pandemic, often accompanied by alterations in the duration and quality of sleep, and mood changes. Yet, manifestations of the latter were also seen in uninfected healthcare personnel working night shifts [ 5 ], and in the population at large due to the unprecedented scope and scale of the societal restrictions [ 6 ]. Moreover, circadian disruptions had been observed before the pandemic in patients suffering from chronic pulmonary disease and other metabolic diseases such as diabetes and obesity [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Uncoupled redox stress: how a temporal misalignment of redox-regulated processes and circadian rhythmicity exacerbates the stressed state

Clark,

Cumpstey,

Santolini

et al. 2023

Open Biol.

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Diurnal and seasonal rhythmicity, entrained by environmental and nutritional cues, is a vital part of all life on Earth operating at every level of organization; from individual cells, to multicellular organisms, whole ecosystems and societies. Redox processes are intrinsic to physiological function and circadian regulation, but how they are integrated with other regulatory processes at the whole-body level is poorly understood. Circadian misalignment triggered by a major stressor (e.g. viral infection with SARS-CoV-2) or recurring stressors of lesser magnitude such as shift work elicit a complex stress response that leads to desynchronization of metabolic processes. This in turn challenges the system's ability to achieve redox balance due to alterations in metabolic fluxes (redox rewiring). We infer that the emerging ‘alternative redox states' do not always revert readily to their evolved natural states; ‘Long COVID’ and other complex disorders of unknown aetiology are the clinical manifestations of such rearrangements. To better support and successfully manage bodily resilience to major stress and other redox challenges needs a clear perspective on the pattern of the hysteretic response for the interaction between the redox system and the circadian clock. Characterization of this system requires repeated (ideally continuous) recording of relevant clinical measures of the stress responses and whole-body redox state (temporal redox phenotyping). The human/animal body is a complex ‘system of systems’ with multi-level buffering capabilities, and it requires consideration of the wider dynamic context to identify a limited number of stress-markers suitable for routine clinical decision making. Systematically mapping the patterns and dynamics of redox biomarkers along the stressor/disease trajectory will provide an operational model of whole-body redox regulation/balance that can serve as basis for the identification of effective interventions which promote health by enhancing resilience.

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Circadian Disruption in Night Shift Work and Its Association with Chronic Pulmonary Diseases

Cited by 4 publications

References 119 publications

Association between Shift Work and Health Outcomes in the General Population in China: A Cross-Sectional Study

Association between Shift Work and Health Outcomes in the General Population in China: A Cross-Sectional Study

Associations between long-term night shift work and incidence of chronic obstructive pulmonary disease: a prospective cohort study of 277,059 UK Biobank participants

Uncoupled redox stress: how a temporal misalignment of redox-regulated processes and circadian rhythmicity exacerbates the stressed state

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