Vaccination against hepatitis B virus has rarely been associated with lichen planus. We report a case of this kind in a child from Nepal. A 12-year-old boy had developed generalized itchy violaceous papules and plaques six weeks after the second dose of hepatitis B virus vaccine. Serum HBsAg and HBeAb were negative, but HBsAb was positive. New crops of generalized, similar eruptions developed after the booster dose of vaccine. All the lesions resolved within three months of systemic steroid therapy. There was no recurrence after one year of follow up. Awareness of such an association is necessary, especially in children, because vaccination campaigns are increasing.
This study emphasizes the need to be aware of the possibility of cases of PKDL in endemic regions of leprosy, as the conditions may be difficult to distinguish clinically and histopathologically.
A 55 years old female came with a lump in the right breast since 1 year. Clinical examination revealed a large mass in the right breast, firm to hard in consistency measuring 6x5.5x5cm. The mass was fixed to the underlying structures. Skin over the mass was red and ulcerated destroying the nipple and areola. A clinical diagnosis of carcinoma of breast was made. FNAC of the mass
Introduction
Coronavirus disease 2019 (COVID-19) vaccine hesitancy amongst healthcare workers (HCW) has been reported in varying degrees in different parts of the world. In this study, we investigate the degree of vaccine hesitancy amongst HCWs and factors associated with it during the second wave of the pandemic in our centre.
Methods
We undertook this single-centre, cross-sectional study in an urban tertiary care hospital, using a modified Oxford COVID-19 vaccine hesitancy scale. We performed descriptive and appropriate univariate analysis. We used the Kruskal Wallis test as appropriate, and Spearman rank correlation to evaluate the relation between general attitude to vaccination and COVID vaccine hesitancy score.
Results
We obtained 223 responses. The majority of HCWs in our sample (n = 201; 90.1%) had received at least one dose of the vaccine. The mean (SD) Oxford vaccine hesitancy score was 28.54 ± 2.05, with no significant difference observed between doctors (28.45 ± 2.26) and nurses (28.68 ± 1.70), or across different specialities. Of the respondents, 92.7% (n = 216) responded positively to taking the vaccine. The lack of dependents at home was the only significant contributor to vaccine hesitancy. Age, gender, marital status, and COVID-19 infection status did not significantly affect vaccine hesitancy.
Conclusion
We found a significantly lower degree of hesitancy towards COVID-19 amongst HCWs in our centre during the pandemic’s second wave. A more comprehensive and multi-centric study is required to validate this finding.
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