Treatment of Old World cutaneous leishmaniasis with dapsone, itraconazole, cryotherapy, and imiquimod, alone and in combination

Abstract

Background Cutaneous leishmaniasis (CL) is a major public health problem. The currently

Topical 40% <i>Loranthus europaeus</i> Ointment as an Alternative Medicine in the Treatment of Acute Cutaneous Leishmaniasis versus Topical 25% Podophyllin Solution

“…Many modalities of therapies can be used in the treatment of CL like Systemic treatment with pentavalent antimonial compounds [4], antifungal [6] [7] dapsone [8], and oral zinc sulfate [9]. Orintralesionally given like pentavalent antimony compounds [10], hypertonic saline [11], 2% zinc sulfate solution [12] and metronidazole [13].…”

“…Systemic treatments like Pentavalent antimonial compounds (sodium stibogluconate and meglumine antimoniate), have been used since many years, but due to the painful intra-muscular administration with long treatment periods, serious side effects are not always available and the emergence of antimonial-resistant [4] [5], other systemic drugs can be used: antifungal [6] [7] dapsone [8], and oral zinc sulfate [9]. While topical treatment had been effectively used eitherintralesionally given like pentavalent antimony compounds [10], hypertonic saline [11], 2% zinc sulfatesolution [12] and metronidazole [13].…”

Topical Treatment Modalities for Old World Cutaneous Leishmaniasis: A Review

“…Systemic itraconazole alone was demonstrated to be inferior to combination therapy in cutaneous leishmaniasis (Al-Mutairi et al, 2009). Topical formulation of this drug for treatment of cutaneous leishmaniasis has not been reported in the literature.…”

Diffuse cutaneous leishmaniasis - A rare cutaneous presentation in an HIV-positive patient

“…Polymerase chain reaction method has the potential to become technique of choice for diagnosis of cutaneous leishmaniasis, but in our case we could not perform it. [2] However, it was not much clear whether this infection is a case of opportunistic infection or immune reconstitution inflammatory syndrome. In India, CL is commonly seen in states of Rajasthan, Bihar, West Bengal, and Orissa; therefore, endemicity of the disease must be taken into consideration for diagnosis.…”