Limitations of fine needle aspiration cytology in subtyping breast malignancies - a report of three cases

Joshi, Arun; Maimoon, Sabiha

doi:10.4103/0970-9371.41899

Cited by 9 publications

(20 citation statements)

References 4 publications

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“…Therefore, the results must be carefully assessed [35], due to certain limitations of FNAC which require final histopathological diagnosis for establishing prognosis and therapy. The key point is to determine the diagnostic accuracy of FNA cytology and to develop distinguishing cytologic criteria addressing the diagnostic challenges [51]. Karim et al showed in rats an FNA sensitivity of 92.3% and specificity of 89.4% for the detection of malignancy in comparison with histologic diagnosis of tissue biopsies.…”

Section: Sensitivity and False Positive Or Negative Resultsmentioning

confidence: 99%

“…Careful assessment of cytological features of squamous cells and the appearance of the background is crucial for achieving a correct di-agnosis. Deep knowledge of the cytomorphology and cytodiagnosis of rare breast malignant tumors is crucial in the FNA analysis [51].…”

Section: Sensitivity and False Positive Or Negative Resultsmentioning

confidence: 99%

“…Fine needle aspiration cytology (FNAC) of the breast is becoming an increasingly important diagnostic tool in the assessment of breast malignancies and their further subtyping with a high degree of accuracy [50,51]. It has been shown to be rapid, minimally invasive and safe diagnostic procedure in pregnancy and lactation, indicating suspicious or malignant findings in 95% of lesions [48,[50][51][52]. ThinPrep Papanicolaou test is considered to be a trusted and widely used technique, much easier and faster as procedure.…”

Section: Fine Needle Aspirationmentioning

confidence: 99%

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Pregnancy associated breast cancer (PABC): Aspects in diagnosis

Kakoulidis¹,

Σκάγιας²,

Politi³

2015

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Diagnosis of a clinical entity like pregnancy associated breast cancer (PABC) is as demanding and challenging as its rarity. Increasing incidence and controversy that exists in the literature upon prognosis, tumor aggressiveness and underlying mechanisms, highlight the importance of optimizing the diagnostic strategy in women with PABC. Adjustment of standard approach for breast cancer by modifying management methods and options plays key role in decision making. Knowledge of diagnostic modalities and their limitations, in accordance with awareness of physiologic hormone-induced changes of pregnancy and lactation, is the fundamental method of diagnosis in PABC. Thorough triple assessment (history/clinical examination, imaging and cytology/histology) enforces healthcare providers with all essential tools to avoid detrimental delay in diagnosis and to confront with their own hesitation to take action due to limited experience of the disease.

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Section: Sensitivity and False Positive Or Negative Resultsmentioning

confidence: 99%

Section: Sensitivity and False Positive Or Negative Resultsmentioning

confidence: 99%

Section: Fine Needle Aspirationmentioning

confidence: 99%

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Pregnancy associated breast cancer (PABC): Aspects in diagnosis

Kakoulidis¹,

Σκάγιας²,

Politi³

2015

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“…8,13 FNAC has certain limitations as it is difficult to subtype breast malignancies. 6,7,9 CONCLUSION FNAC is a safe outpatient procedure, which is cost effective. Our study shows most of the breast lesions are benign and needs only reassurance and early diagnosis to prevent patients discomfort and anxiety.…”

Section: Discussionmentioning

confidence: 95%

Pattern of breast lesions on fine-needle aspiration cytology in consecutive 70 cases: a retrospective and prospective analysis of one year

Singh¹,

Saproo

2016

Int J Res Med Sci

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“…Although today, breast cyst aspiration is a routine procedure 14 , evaluation of nonbloody cyst fluidcan at times be of non diagnostic value 15 .False Negative Cytologic Diagnosis of Breast Carcinoma has also been described 16 .…”

mentioning

confidence: 99%

Meme Kistlerinin Patolojik Panoraması

Sankaye¹,

Kachewar²

2014

Cukurova Medical Journal

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Purpose: Cystic breast lesions are a common finding in young as well as elderly females. Although, mostly benign; they can at times be malignant too. Timely diagnosis is possible with help of Fine needle aspiration cytology (FNAC). This study was carried out with the aim of studying the panorama of various cystic breast lesions on FNAC in our setup. Materials and Methods: This was a four year prospective study carried out from May 2010 to January 2014. Cystic nature of breast mass was confirmed by palpation and by sonomammography. FNAC was then performed and the smears were stained with MGG and Papanicolaou stain. Results: Out of the 72 cases that were diagnosed to be cystic breast lesions clinically or on sonomammography, 64 were found to be benign and 08 were found to be malignant on FNAC. Retrospective imaging correlation of the 08 cystic cases revealed that they were of complex cystic nature and had either thick septae( 03), solid areas (04) or dense contents (01) within. This internal nature of cystic lesions that were found to be malignant on FNAC was not identifiable by clinical palpation alone. None of the lesions diagnosed as simple cystic lesion on sonomammography was found to be malignant on FNAC. Conclusions: FNAC is a satisfactory technique for the primary categorization of palpable cystic breast lumps into benign and malignant categories. Cystic breast lesions are more commonly benign than malignant. Palpation alone cannot identify the simple or complex nature of any palpable cystic lesion and hence sonomammography and ultrasound guided FNAC are indicated in complex cystic lesions of breast.

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Limitations of fine needle aspiration cytology in subtyping breast malignancies - a report of three cases

Cited by 9 publications

References 4 publications

Pregnancy associated breast cancer (PABC): Aspects in diagnosis

Pregnancy associated breast cancer (PABC): Aspects in diagnosis

Pattern of breast lesions on fine-needle aspiration cytology in consecutive 70 cases: a retrospective and prospective analysis of one year

Meme Kistlerinin Patolojik Panoraması

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