Lichen Planus after HBV Vaccination in a Child: A Case Report from Nepal

Agrawal, Sudha; Garg, Vijay Kumar; Joshi, Arun; Agarwalla, Arun; Sah, Shatrughan Prasad

doi:10.1111/j.1346-8138.2000.tb02240.x

Cited by 19 publications

(23 citation statements)

References 8 publications

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“…So wurde von mehreren Patienten berichtet, die nach aktiver Immunisierung gegen HBV innerhalb weniger Wochen lichenoide Hautveränderungen entwickelten. Seit 1990 wurden 26 Patienten mit durch Hepatitis-B-Impfung ausgelöstem Lichen ruber planus beschrieben, darunter 7 Kinder [1,10,12,17]. In den meisten Fäl-len entwickelten die Patienten 2-3 Monate nach der ersten Injektion des Impfstoffs papulöse, juckende Hautverände-rungen, die histologisch als Lichen ruber planus gesichert wurden.…”

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Lichen ruber planus nach Hepatitis-B-Impfung

et al. 2002

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Lichen planus is a T cell mediated papular skin disease. Chronic hepatic disorders, especially chronic hepatitis, have been found to be associated with lichen planus. Recently, it has been recognized that lichen planus can be triggered by hepatitis B vaccination. Here we report on cases of lichen planus triggered by vaccination and review the current literature. Hepatitis B vaccination is being increasingly used and should be considered as a possible trigger of lichen planus.

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Section: Schlüsselwörterunclassified

Lichen ruber planus nach Hepatitis-B-Impfung

et al. 2002

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“…[13] The conditions commonly associated juvenile OLP include (1) previous history of hepatitis B vaccination; (2) liver disease and (3) genetic predisposition, as in familial LP. [14][15][16] Alterations in clinical features of adult and juvenile LP have been noticed. Several authors have reported that LP in children could exhibit atypical features, like "linear" pattern uncommon seen in adults.…”

Section: Discussionmentioning

confidence: 99%

Juvenile oral erosive lichen planus - A rare case report

Jahan¹,

Vandana²,

Rangdhol³

et al. 2017

IJMDCR

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Lichen planus (LP) is a chronic autoimmune mucocutaneous disease that predominantly affects adults and occurs less frequently in the pediatric patients. Oral LP in childhood is a rare entity with very few cases cited in the literature. The objective of this paper is to contribute a clinically and histologically documented case of juvenile oral LP to the literature. Despite the fact of rare occurrence, early identification and diagnosis of this condition by dental specialists can have a huge impact on the oral health of affected pediatric patients.

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“…Since then, less than 20 cases of LP or lichenoid reactions following HBV vaccination with all types of vaccines (recombinant and plasma-derived) have been reported [3, 5, 10, 11, 12, 13, 14]. Given the diffusion of HBV vaccination, the incidence of postvaccine LP is low.…”

Section: Discussionmentioning

confidence: 99%

“…Since the reaction has occurred following vaccination with all types of HBV vaccines and given the diversity of these vaccines, it seems plausible that any factor common in all vaccines is a candidate causal factor. The only common constituent is the protein S fraction of the HBsAg [3, 5, 9, 10, 11, 12, 13, 14]. Based on the clinical and histological features and the time course of the postvaccine LP, it has been speculated that a T-cell-mediated, graft-versus-host-like reaction takes place.…”

Section: Discussionmentioning

confidence: 99%

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Papulonodular Lichenoid and Pseudolymphomatous Reaction at the Injection Site of Hepatitis B Virus Vaccination

et al. 2002

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Immunization with the hepatitis B virus (HBV) is effective and safe with an estimated incidence of adverse reactions, either local or systemic, of less than 0.1%. Cutaneous side effects are rare and include lichen planus (LP) and lichenoid reactions. We report the case of a 21-year-old female, in whom a persistent, papulonodular lesion developed at the site of the injection, 6 weeks after the second dose of the HBV. Histological examination revealed lichenoid and pseudolymphomatous features. In addition, sensitization to thiomersal, a vaccine constituent, was documented by patch testing. The association of LP with chronic liver disease is well established. Furthermore, less than 20 cases of lichen or lichenoid reactions, following HBV vaccination, have been reported. Although several arguments have been presented, it is still debated whether there is a causal association or the occurrence of LP following HBV vaccination is a simple coincidence. It has been speculated that a T-cell-mediated, graft-versus-host-like reaction, triggered by a sensitizing protein, is directed against keratinocytes expressing an epitope of hepatitis B surface antigen or a similar epitope. Our case may represent a localized lichenoid reaction to HBV vaccination, a local reactive hyperplasia or a persisting delayed hypersensitivity reaction to a vaccine constituent. This is the first case of a local lichenoid reaction at the injection site of the HBV vaccine, providing further documentation for a causal association linking the HBV vaccine with LP.

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Lichen Planus after HBV Vaccination in a Child: A Case Report from Nepal

Cited by 19 publications

References 8 publications

Lichen ruber planus nach Hepatitis-B-Impfung

Lichen ruber planus nach Hepatitis-B-Impfung

Juvenile oral erosive lichen planus - A rare case report

Papulonodular Lichenoid and Pseudolymphomatous Reaction at the Injection Site of Hepatitis B Virus Vaccination

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