Circadian dynamics of vasopressin in mouse selection lines: Translation and release in the SCN

Veen, Daan R. van der; Castillo, Marina; Zee, Eddy A. van der; Jansen, Koen; Gerkema, Menno P.; Bult‐Ito, Abel

doi:10.1016/j.brainres.2005.07.068

Cited by 10 publications

(7 citation statements)

References 51 publications

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“…AVP is rhythmically expressed both in vivo and in vitro (Cassone et al 1988; Dardente et al 2004; Mahoney et al 2009; Miller, et al 2006; Noguchi and Watanabe 2008; Shinohara, et al 1998; Sukhov, et al 1993; Van der Veen, et al 2005; Yoshikawa et al 2015). Of three AVP receptors, V 1a (V1) and V 1b (V3) are expressed within the SCN (Kalamatianos, et al 2004a; Li, et al 2009), which are both Gα q coupled receptors that stimulate phospholipase C to cause DAG-mediated activation of PKC and IP3-induced mobilization of intracellular calcium (Figure 4C, Maybauer, et al 2008).…”

Section: Scn Coupling Mechanismsmentioning

confidence: 99%

Collective timekeeping among cells of the master circadian clock

Evans

2016

Journal of Endocrinology

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The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is the master circadian clock that coordinates daily rhythms in behavior and physiology in mammals. Like other hypothalamic nuclei, the SCN displays an impressive array of distinct cell types characterized by differences in neurotransmitter and neuropeptide expression. Individual SCN neurons and glia are able to display self-sustained circadian rhythms in cellular function that are regulated at the molecular level by a 24 h transcriptional-translational feedback loop. Remarkably, SCN cells are able to harmonize with one another to sustain coherent rhythms at the tissue level. Mechanisms of cellular communication in the SCN network are not completely understood, but recent progress has provided insight into the functional roles of several SCN signaling factors. This review discusses SCN organization, how intercellular communication is critical for maintaining network function, and the signaling mechanisms that play a role in this process. Despite recent progress, our understanding of SCN circuitry and coupling is far from complete. Further work is needed to map the circuitry of the SCN fully and define the signaling mechanisms that allow for collective timekeeping in the SCN network.

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Section: Scn Coupling Mechanismsmentioning

confidence: 99%

Collective timekeeping among cells of the master circadian clock

Evans

2016

Journal of Endocrinology

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“…European ground squirrels, Spermophilus citellus, have absent or suppressed circadian rhythmicity when first emerging from hibernation; spontaneous regeneration of rhythmicity correlates positively with the number of Avp-ir neurons in the SCN (Hut et al, 2002). In two mice lines selected for nest-building behavior, differences in circadian rhythms are accompanied by different number of Avp-ir neurons in the SCN, as well as different transport and release of Avp in the SCN ( Van der Veen et al, 2005). Reduced diurnal rhythms of Avpr1a mRNA in the SCN are seen in aged (19-20 months old), compared to young, rats (2-3 months old) (Kalamatianos et al, 2004).…”

Section: Regulation Of Behavior By the Suprachiasmatic Nucleusmentioning

confidence: 99%

Vasopressin: Behavioral roles of an “original” neuropeptide

Caldwell

Lee

Macbeth

et al. 2008

Progress in Neurobiology

427

416

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Vasopressin (Avp) is mainly synthesized in the magnocellular cells of the hypothalamic supraoptic (SON) and paraventricular nuclei (PVN) whose axons project to the posterior pituitary. Avp is then released into the blood stream upon appropriate stimulation (e.g., hemorrhage or dehydration) to act at the kidneys and blood vessels. The brain also contains several populations of smaller, parvocellular neurons whose projections remain within the brain. These populations are located within the PVN, bed nucleus of the stria terminalis (BNST), medial amygdala (MeA) and suprachiasmatic nucleus (SCN).Since the 1950's, research examining the roles of Avp in the brain and periphery has intensified. The development of specific agonists and antagonists for Avp receptors has allowed for a better elucidation of its contributions to physiology and behavior. Anatomical, pharmacological and transgenic, including "knockout," animal studies, have implicated Avp in the regulation of various social behaviors across species.Avp plays a prominent role in the regulation of aggression, generally of facilitating or promoting it. Affiliation and certain aspects of pair-bonding are also influenced by Avp. Memory, one of the first brain functions of Avp that was investigated, has been implicated especially strongly in social recognition. The roles of Avp in stress, anxiety, and depressive states are areas of active exploration. In this review, we concentrate on the scientific progress that has been made on understanding the role of Avp in regulating of these and other behaviors across species, as well as discuss the implications for human behavior.

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“…, 1999), is reduced in the SCN of CalB−/− mice. The pattern of vasopressin expression seen in CalB−/− mice is in agreement with previous work (Van der Veen et al. , 2005).…”

Section: Discussionmentioning

confidence: 99%

Targeted mutation of the calbindin D_28K gene disrupts circadian rhythmicity and entrainment

Kriegsfeld

Mei

Yan

et al. 2008

Eur J of Neuroscience

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The suprachiasmatic nucleus (SCN) is the principal circadian pacemaker in mammals. A salient feature of the SCN is that cells of a particular phenotype are topographically organized; this organization defines functionally distinct subregions that interact to generate coherent rhythmicity. In Syrian hamsters (Mesocricetus auratus), a dense population of directly retinorecipient calbindin D(28K) (CalB) neurons in the caudal SCN marks a subregion critical for circadian rhythmicity. In mouse SCN, a dense cluster of CalB neurons occurs during early postnatal development, but in the adult CalB neurons are dispersed through the SCN. In the adult retina CalB colocalizes with melanopsin-expressing ganglion cells. In the present study, we explored the role of CalB in modulating circadian function and photic entrainment by investigating mice with a targeted mutation of the CalB gene (CalB-/- mice). In constant darkness (DD), CalB-/- animals either become arrhythmic (40%) or exhibit low-amplitude locomotor rhythms with marked activity during subjective day (60%). Rhythmic clock gene expression is blunted in these latter animals. Importantly, CalB-/- mice exhibit anomalies in entrainment revealed following transfer from a light : dark cycle to DD. Paradoxically, responses to acute light pulses measured by behavioral phase shifts, SCN FOS protein and Period1 mRNA expression are normal. Together, the developmental pattern of CalB expression in mouse SCN, the presence of CalB in photoresponsive ganglion cells and the abnormalities seen in CalB-/- mice suggest an important role for CalB in mouse circadian function.

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Circadian dynamics of vasopressin in mouse selection lines: Translation and release in the SCN

Cited by 10 publications

References 51 publications

Collective timekeeping among cells of the master circadian clock

Collective timekeeping among cells of the master circadian clock

Vasopressin: Behavioral roles of an “original” neuropeptide

Targeted mutation of the calbindin D_28K gene disrupts circadian rhythmicity and entrainment

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Circadian dynamics of vasopressin in mouse selection lines: Translation and release in the SCN

Cited by 10 publications

References 51 publications

Collective timekeeping among cells of the master circadian clock

Collective timekeeping among cells of the master circadian clock

Vasopressin: Behavioral roles of an “original” neuropeptide

Targeted mutation of the calbindin D28K gene disrupts circadian rhythmicity and entrainment

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Targeted mutation of the calbindin D_28K gene disrupts circadian rhythmicity and entrainment