Circadian Fatigue or Unrecognized Restless Legs Syndrome? The Post-Polio Syndrome Model

Romigi, Andrea; Maestri, Michelangelo

doi:10.3389/fneur.2014.00115

Cited by 8 publications

(6 citation statements)

References 16 publications

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“…Fatigue is thought to exhibit circadian variations throughout the day (90). Sleep disorders such as restless leg syndrome (RLS) (87, 91–94), sleep related breathing disturbances (95), obstructive sleep apnoea (OSA) (96), excessive daytime somnolence (EDS), and periodic limb movement in sleep (PLMS) (97) are not only often reported in PPS but they are likely to play an important role in the pathogenesis of fatigue in PPS (98, 99). Fatigue is thought to be more severe in PPS with RLS, and correlate to the severity of RLS (87).…”

Section: Resultsmentioning

confidence: 99%

Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease

et al. 2019

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Post-polio syndrome (PPS) is a neurological condition that affects polio survivors decades after their initial infection. Despite its high prevalence, the etiology of PPS remains elusive, mechanisms of progression are poorly understood, and the condition is notoriously under-researched. While motor dysfunction is a hallmark feature of the condition, generalized fatigue, sleep disturbance, decreased endurance, neuropsychological deficits, sensory symptoms, and chronic pain are also often reported and have considerable quality of life implications in PPS. The non-motor aspects of PPS are particularly challenging to evaluate, quantify, and treat. Generalized fatigue is one of the most distressing symptoms of PPS and is likely to be multifactorial due to weight-gain, respiratory compromise, poor sleep, and polypharmacy. No validated diagnostic, monitoring, or prognostic markers have been developed in PPS to date and the mainstay of therapy centers on symptomatic relief and individualized rehabilitation strategies such as energy conservation and muscle strengthening exercise regimes. Despite a number of large clinical trials in PPS, no effective disease-modifying pharmacological treatments are currently available.

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Section: Resultsmentioning

confidence: 99%

Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease

et al. 2019

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“…Although these authors did not explore clinical RLS in the PPS sample, it is intriguing to note that fatigue could resemble the circadian pattern of RLS symptoms. On the basis of the association presently proved between general fatigue and RLS, and considering that RLS could be difficult to identify because fatigue itself may mask RLS symptoms, one could argue that unrecognized RLS may represent a possible cause of the ‘circadian’ fatigue observed in PSS .…”

Section: Discussionmentioning

confidence: 99%

Restless legs syndrome and post polio syndrome: a case−control study

Romigi

Pierantozzi

Placidi

et al. 2014

Euro J of Neurology

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“…In case of OSA, BiPAP, respiratory physical therapy, as well as, flu vaccines are among the resources indicated 6,8,10 . These sleep disorders may contribute to a cardinal PPS symptom: fatigue 5,8,11,12 . Considering its importance, some approaches were tried to minimize its impact.…”

Section: Sleep Disturbancesmentioning

confidence: 99%

Currents issues in cardiorespiratory care of patients with post-polio syndrome

Orsini

Lopes

Guimarães

et al. 2016

Arq. Neuro-Psiquiatr.

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Post-polio syndrome (PPS) is a condition that affects polio survivors years after recovery from an initial acute attack of the poliomyelitis virus. Most often, polio survivors experience a gradual new weakening in muscles that were previously affected by the polio infection. The actual incidence of cardiovascular diseases (CVDs) in individuals suffering from PPS is not known. However, there is a reason to suspect that individuals with PPS might be at increased risk. Method A search for papers was made in the databases Bireme, Scielo and Pubmed with the following keywords: post polio syndrome, cardiorespiratory and rehabilitation in English, French and Spanish languages. Although we targeted only seek current studies on the topic in question, only the relevant (double-blind, randomized-controlled and consensus articles) were considered. Results and Discussion Certain features of PPS such as generalized fatigue, generalized and specific muscle weakness, joint and/or muscle pain may result in physical inactivity deconditioning obesity and dyslipidemia. Respiratory difficulties are common and may result in hypoxemia. Conclusion Only when evaluated and treated promptly, somE patients can obtain the full benefits of the use of respiratory muscles aids as far as quality of life is concerned.

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Circadian Fatigue or Unrecognized Restless Legs Syndrome? The Post-Polio Syndrome Model

Cited by 8 publications

References 16 publications

Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease

Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease

Restless legs syndrome and post polio syndrome: a case−control study

Currents issues in cardiorespiratory care of patients with post-polio syndrome

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