Circadian Interrelationships Among Levels of Plasma Fibrinogen, Blood Platelets, and Serum Interleukin-6

Kanabrocki, Eugene L.; Sothern, Robert B.; Messmore, Harry L.; Roitman-Johnson, B.; McCormick, James B.; Dawson, Susan; Bremner, Fraser W.; Third, Jane L.H.C.; Nemchausky, Bernard A.; Shirazi, Parvez; Scheving, Lawrence E.

doi:10.1177/107602969900500108

Cited by 45 publications

(31 citation statements)

References 38 publications

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“…Our results therefore may not be generalizeable to women in two-week cycles or those getting more than four cycles of treatment. In addition, we obtained a single blood sample at each study timepoint which is not ideal for factors such as IL-6 which display diurnal variability (Kanabrocki et al, 1999;Muc-Wierzgon et al, 1996). We attempted to address this limitation by sampling blood within a fixed time each testing day but in the context of the clinic setting we could only limit our blood sampling times to within a range of approximately 4 hours.…”

Section: Discussionmentioning

confidence: 99%

Predictors of inflammation in response to anthracycline-based chemotherapy for breast cancer

Mills

Ancoli‐Israel

Parker

et al. 2008

Brain, Behavior, and Immunity

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Although chemotherapy for breast cancer can increase inflammation, few studies have examined predictors of this phenomenon. This study examined potential contributions of demographics, disease characteristics, and treatment regimens to markers of inflammation in response to chemotherapy for breast cancer. Thirty-five women with stage I -III-A breast cancer (mean age 50 years) were studied prior to cycle 1 and prior to cycle 4 of anthracycline-based chemotherapy. Circulating levels of inflammatory markers with high relevance to breast cancer were examined, including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), Interleukin-1 receptor antagonist (IL1-RA), vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), Interleukin-(IL-6), soluble P-selectin (sP-selectin), and von Willebrand factor (vWf). Chemotherapy was associated with elevations in VEGF (p≤0.01), sICAM-1 (p≤0.01), sP-selectin (p≤0.02) and vWf (p≤0.05). Multiple regression analysis controlling for age and body mass index (BMI) showed that higher post-chemotherapy levels of inflammation were consistently related to higher prechemotherapy levels of inflammation (p's ≤0.05) as well as to certain disease characteristics. Postchemotherapy IL-6 levels were higher in patients who had larger tumors (p≤0.05) while postchemotherapy VEGF levels were higher in patients who had smaller tumors (p≤0.05). Postchemotherapy sP-selectin levels were highest in women who had received epirubicin, cytoxan, 5fluorouracil chemotherapy (p≤0.01). These findings indicate that chemotherapy treatment can be associated with elevations in certain markers of inflammation, particularly markers of endothelial and platelet activation. Inflammation in response to chemotherapy is most significantly related to inflammation that existed prior to chemotherapy but also potentially to treatment regimen and to certain disease characteristics.

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Section: Discussionmentioning

confidence: 99%

Predictors of inflammation in response to anthracycline-based chemotherapy for breast cancer

Mills

Ancoli‐Israel

Parker

et al. 2008

Brain, Behavior, and Immunity

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“…19,20 In a study by Kanabrocki et al, platelet and fibrinogen aggregation were reported in the afternoon and in the morning, respectively. 21 Yasuda et al stated that the thromboplastin time had a significant reduction in two of the four intervals studied. 22 It seems that platelets also have circadian rhythms.…”

Section: The Effect Of Acute Training and Circadian Rhythm On Blood Hmentioning

confidence: 94%

The Effect of Acute Training and Circadian Rhythm on Blood Hemostasis in Female Athletes

Mahmoodinezhad¹,

Shakerian²,

Ghalavand³

et al. 2016

Int J Basic Sci Med

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Background: Circadian rhythm and physical activity are factors that influence the homeostasis of blood. This study aimed to investigate the effect of exhaustive exercise in the morning and evening on the blood hemostasis in female athletes. Methods: In the present quasi-experimental study, 30 female athletes aged 18-25 were selected by convenience sampling method and randomly divided into two groups (morning and afternoon exercises). The standard Bruce protocol test was used. In the present study, platelets, fibrinogen, and thromboplastin time were measured as indicators of blood coagulation before and after testing. Paired t-test and covariance analysis were used to analyze the measured indices and P ≤ 0.05 was considered significant. Results: An acute exhausting aerobic training session in both groups significantly increased platelet and fibrinogen levels, but a significant decrease was observed in thromboplastin time. Considering the training time, significant difference was observed in the blood thromboplastin time in the morning in comparison with the afternoon. Conclusion: According to the results of this study, the circadian rhythm and acute exhausting aerobic training are effective factors on the blood coagulation and a training session in the morning compared with the evening training has a greater effect on the blood coagulation.

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“…Whereas the rhythm has been approximated by the cosine curve with a single peak in the early morning (38), reconsideration of the original data of Kanabrocki et al (38) suggests the presence of the second peak or a shoulder in the evening. Therefore, human fibrinogen seems to be set to increase rapidly in the morning and persist around the daytime, i.e.…”

Section: Two-peaked Day/night Rhythms In Expression Of Fibrinogenmentioning

confidence: 99%

“…a physically active period in human. The peak in the early morning has been implicated in the incidence of arterial ischemic diseases such as myocardial infarction (38).…”

Section: Two-peaked Day/night Rhythms In Expression Of Fibrinogenmentioning

confidence: 99%

Two-peaked Synchronization in Day/Night Expression Rhythms of the Fibrinogen Gene Cluster in the Mouse Liver

Sakao

Ishihara

Horikawa

et al. 2003

Journal of Biological Chemistry

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Genes expressed with day/night rhythms in the mouse liver were searched for by microarray analysis using an in-house array harboring mouse liver cDNAs. The rhythmic expression with a single peak and trough level was confirmed by RNA blot analysis for 3␤-Hsd and Gabarapl1 genes exhibiting a peak in the light phase and Spot14, Hspa8, Hspa5, and Hsp84-1 genes showing a peak in the dark phase. On the other hand, mRNA levels for all of the three fibrinogen subunits, A␣, B␤ and ␥, exhibited two peaks each in the light and dark phases in a synchronized manner. This two-peaked rhythmic pattern of fibrinogen genes as well as the single peaktrough pattern of other genes was diminished or almost completely lost in the liver of Clock mutant mice, suggesting that the two-peaked expression is also under the control of oscillation-generating genes. In constant darkness, the first peak of the expression rhythm of fibrinogen genes was almost intact, but the second peak disappeared. Therefore, although the first peak in the subjective day is a component of the innate circadian rhythm, the second peak seems to require light stimuli. Fasting in constant darkness caused shifts of time phases of the circadian rhythms. Protein levels of the fibrinogen subunits in whole blood also exhibited circadian rhythms. In the mouse and human loci of the fibrinogen gene cluster, a number of sequence elements resembling circadian transcription factor-binding sites were found. The fibrinogen gene locus provides a unique system for the study of two-peaked day/night rhythms of gene expression in a synchronized form.In mammals, intracellular oscillation generators for circadian rhythms reside in various peripheral organs such as liver as well as in the central pacemaker, the suprachiasmatic nucleus (SCN) 1 of the hypothalamus (1, 2). The SCN and peripheral tissues seem to share common molecular mechanisms for generating the circadian oscillation. The widely accepted mechanism is autoregulatory feedback inhibition of period (Per) and cryptochrome (Cry) genes by their own protein products in antagonism with the positive transcription factor of the CLOCK-BMAL1 heterodimer (3-8).The time phase of the SCN oscillator is adjusted by light stimuli everyday in the light-dark condition (1, 2). The SCN then controls or affects the oscillators of peripheral cells in both relatively direct and indirect manners. The liver provides a well characterized example of these regulations. Although oscillation generators of liver cells are under the circadian control of glucocorticoids (9, 10), presumably through the hypothalamus-hypophysis-adrenal axis, time phases of the liver oscillators are more profoundly affected by feeding time (11-13). Artificial diurnal feeding of nocturnal rodents can completely uncouple the oscillation phase of the liver from that of the SCN. Seemingly, the SCN regulates the liver oscillators indirectly by controlling the sleep-awakeness phase that in turn determines the feeding time under the natural condition.Recently, hundreds of genes exhibit...

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Circadian Interrelationships Among Levels of Plasma Fibrinogen, Blood Platelets, and Serum Interleukin-6

Cited by 45 publications

References 38 publications

Predictors of inflammation in response to anthracycline-based chemotherapy for breast cancer

Predictors of inflammation in response to anthracycline-based chemotherapy for breast cancer

The Effect of Acute Training and Circadian Rhythm on Blood Hemostasis in Female Athletes

Two-peaked Synchronization in Day/Night Expression Rhythms of the Fibrinogen Gene Cluster in the Mouse Liver

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