Circadian Modulation of 8-Oxoguanine DNA Damage Repair

Manzella, Nicola; Bracci, Massimo; Strafella, Elisabetta; Staffolani, Sara; Ciarapica, Veronica; Copertaro, Alfredo; Rapisarda, Venerando; Ledda, Caterina; Amati, Monica; Valentino, Matteo; Tomasetti, Marco; Stevens, Richard G.; Santarelli, Lory

doi:10.1038/srep13752

Cited by 62 publications

(69 citation statements)

References 46 publications

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“…When chemical agents are concerned, primary prevention entails replacing a toxic agent with a non-toxic one. Though, certain mutagenic/carcinogenic agents can be produced in synthetic processes as intermediates or as waste products (45)(46)(47)(48)(49)(50)(51)(52)(53)(54).…”

Section: Discussionmentioning

confidence: 99%

Lead exposure and plasma mRNA expression in ERBB2 gene

Ferrante

Ledda

Conti

et al. 2017

Molecular Medicine Reports

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Epidemiologic data for carcinogenicity in those exposed to lead (Pb) suggests relations with cancers although the totality of the evidence is inconsistent. Alterations in the expression of ERBB receptors have been studied during the development and malignant transformation of different kinds of human tumors where they induce proliferation, angiogenesis and metastasis generation. Relevant clinical data demonstrate the role of ERBB2 receptors in the development and malignancy of human cancers. Therefore, the objective of the present investigation is to give more information on the link between plasma mRNA expression in ERBB2 gene and lead blood levels in a healthy population. Blood samples, socio‑demographic, exposure and health data were obtained from 48 healthy men. Real‑time polymerase chain reaction assays were performed to detect ERBB2 gene transcripts, ΔΔCt method was used to quantify gene expression. Pb blood level was assayed using high‑resolution sector field inductively coupled mass spectrometry and is expressed in µg/dl. Plasma mRNA expression in ERBB2 gene was 6.44±3.07 ΔΔCt; Pb blood levels was 16.07±6.74 µg/dl. Regression analysis revealed a significant association (r2=0.5345; p<0.0001) between Pb levels and mRNA expression in ERBB2. So far, it has still not been established if the expression of ERBB2 receptors is influenced by Pb exposure. On the base of the above reported data, we believe an in vitro study might be useful, to understand the molecular mechanisms implicated.

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Section: Discussionmentioning

confidence: 99%

Lead exposure and plasma mRNA expression in ERBB2 gene

Ferrante

Ledda

Conti

et al. 2017

Molecular Medicine Reports

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“…Manzella et al 35 found that pre-sleep levels of oxidative DNA damage measured in lymphocytes of healthy subjects after a full period of wakefulness during which very little melatonin was secreted, were significantly higher than post-sleep levels, after a full night of sleep during which a normal melatonin profile was produced. OGG1 expression levels were also found to be higher in the post-sleep samples, which may have contributed to the observed effects.…”

Section: Discussionmentioning

confidence: 99%

Oxidative DNA damage during sleep periods among nightshift workers

et al. 2016

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Reduced excretion of 8-OH-dG among nightshift workers during day sleep may reflect reduced functioning of DNA repair machinery, which could potentially lead to increased cellular levels of oxidative DNA damage. Melatonin disruption among nightshift workers may be responsible for the observed effect, as melatonin is known to enhance repair of oxidative DNA damage. Quality of sleep may similarly impact DNA repair. Cellular levels of DNA damage will need to be evaluated in future studies to help interpret these findings.

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“…[174]. This conflicting result may be explained by the samples being collected at different points in the day, since the circadian clock can modulate this measure [175]. …”

Section: Common Usesmentioning

confidence: 99%

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

Benjamin²,

2017

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Methylsulfonylmethane (MSM) has become a popular dietary supplement used for a variety of purposes, including its most common use as an anti-inflammatory agent. It has been well-investigated in animal models, as well as in human clinical trials and experiments. A variety of health-specific outcome measures are improved with MSM supplementation, including inflammation, joint/muscle pain, oxidative stress, and antioxidant capacity. Initial evidence is available regarding the dose of MSM needed to provide benefit, although additional work is underway to determine the precise dose and time course of treatment needed to provide optimal benefits. As a Generally Recognized As Safe (GRAS) approved substance, MSM is well-tolerated by most individuals at dosages of up to four grams daily, with few known and mild side effects. This review provides an overview of MSM, with details regarding its common uses and applications as a dietary supplement, as well as its safety for consumption.

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Circadian Modulation of 8-Oxoguanine DNA Damage Repair

Cited by 62 publications

References 46 publications

Lead exposure and plasma mRNA expression in ERBB2 gene

Lead exposure and plasma mRNA expression in ERBB2 gene

Oxidative DNA damage during sleep periods among nightshift workers

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

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