Circadian ontogeny through the lens of nonparametric variables of actigraphy

Ferreira, Ana Beatriz Damiani; Schaedler, Thais; Mendes, Juliana Viana; Anacleto, Tâmile Stella; Louzada, Fernando Mazzilli

doi:10.1080/07420528.2019.1636814

Cited by 7 publications

(8 citation statements)

References 35 publications

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“…One possible way to better characterize the circadian rhythm with actigraphy would be to validate the NPCRA against gold standard measures first, and then to establish normative values across different age groups in both typically developing children and in children with ASD. Only recently, a few studies have attempted to address this research gap [82][83][84]. However, only one study investigated the NPCRA, involving solely 24-h recordings, in children ages 4-11 years [83].…”

Section: Discussionmentioning

confidence: 99%

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Disturbances of Continuous Sleep and Circadian Rhythms Account for Behavioral Difficulties in Children with Autism Spectrum Disorder

Yavuz-Kodat

Reynaud

Geoffray

et al. 2020

JCM

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Sleep disorders are among the most common comorbidities in children with Autism Spectrum Disorder (ASD), and subjectively defined sleep disturbances have been related to ASD symptom severity. However, no study has investigated the differential impact of objectively measured sleep and circadian rhythm disturbances on behavioral difficulties in this population. Fifty-two children with ASD aged 3–10 years underwent assessments of sleep and circadian rest–activity rhythms objectively with actigraphy and subjectively with the Children’s Sleep Habits Questionnaire. Behavioral difficulties were assessed using the ABC-C. Group comparison analyses were used to compare sleep and circadian rhythm parameters of children with higher and lower behavioral difficulties and dominance analysis to rank predictors and address multicollinearity. Children with high irritability had a shorter continuous sleep period compared to those with lower irritability (−60 min, p = 0.04), as well as those with high stereotypic behaviors compared to children with less stereotypies (−75 min, p = 0.006). Objective circadian and sleep disturbances accounted together for, respectively, 17%, 18% and 36% of the variance in social withdrawal, irritability and stereotypic behaviors. The identification of both sleep and circadian rhythm disturbances as explanatory factors for behavioral difficulties warrants their inclusion in the existing behavioral management strategies for children with ASD.

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Section: Discussionmentioning

confidence: 99%

“…Only recently, a few studies have attempted to address this research gap [82][83][84]. However, only one study investigated the NPCRA, involving solely 24-h recordings, in children ages 4-11 years [83]. Further work on this topic using longer follow-up periods is therefore needed.…”

Section: Discussionmentioning

confidence: 99%

Disturbances of Continuous Sleep and Circadian Rhythms Account for Behavioral Difficulties in Children with Autism Spectrum Disorder

Yavuz-Kodat

Reynaud

Geoffray

et al. 2020

JCM

View full text Add to dashboard Cite

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“…The IV or fragmentation relates to the degeneration of the circadian timing system which is associated with daytime sleepiness or nocturnal arousals, poor sleep, decreased quality of life, poor cognitive and motor performance ( 56 , 82 , 83 ). IS correlates with synchronization of the circadian system with external zeitgebers like light-dark cycles through photic synchronization ( 84 ). In this cohort, disease severity was associated strongly with the synchronization circadian timing system (IS) but subclinical inflammation was more sensitive to detect by fragmentation or poor functioning of the circadian timing system (IV).…”

Section: Discussionmentioning

confidence: 99%

Disrupted Circadian Rest-Activity Cycles in Inflammatory Bowel Disease Are Associated With Aggressive Disease Phenotype, Subclinical Inflammation, and Dysbiosis

et al. 2022

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Patients with inflammatory bowel disease (IBD)—Crohn's disease (CD), and ulcerative colitis (UC), have poor sleep quality. Sleep and multiple immunologic and gastrointestinal processes in the body are orchestrated by the circadian clock, and we recently reported that a later category or chronotype of the circadian clock was associated with worse IBD specific outcomes. The goal of this study was to determine if circadian misalignment by rest-activity cycles is associated with markers of aggressive disease, subclinical inflammation, and dysbiosis in IBD. A total of 42 patients with inactive but biopsy-proven CD or UC and 10 healthy controls participated in this prospective cohort study. Subjects were defined as having an aggressive IBD disease history (steroid dependence, use of biologic or immunomodulator, and/or surgery) or non-aggressive history. All participants did two weeks of wrist actigraphy, followed by measurement of intestinal permeability and stool microbiota. Wrist actigraphy was used to calculate circadian markers of rest-activity– interdaily stability (IS), intradaily variability (IV), and relative amplitude (RA). Aggressive IBD history was associated with decrease rest-activity stability (IS) and increased fragmentation compared to non-aggressive IBD and health controls at 0.39 ±.15 vs. 0.51 ± 0.10 vs. 0.55 ± 0.09 (P < 0.05) and 0.83 ± 0.20 vs. 0.72 ± 0.14 (P < 0.05) but not HC at 0.72 ± 0.14 (P = 0.08); respectively. There was not a significant difference in RA by IBD disease history. Increased intestinal permeability and increased TNF-α levels correlated with an increased rest activity fragmentation (IV) at R = 0.35, P < 0.05 and R = 0.37, P < 0.05, respectively; and decreased rest-activity amplitude (RA) was associated with increased stool calprotectin at R = 0.40, P < 0.05. Analysis of intestinal microbiota showed a significant decrease in commensal butyrate producing taxa and increased pro-inflammatory bacteria with disrupted rest-activity cycles. In this study, different components of circadian misalignment by rest-activity cycles were associated with a more aggressive IBD disease history, increased intestinal permeability, stool calprotectin, increased pro-inflammatory cytokines, and dysbiosis. Wrist activity allows for an easy non-invasive assessment of circadian activity which may be an important biomarker of inflammation in IB.

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“…Using the Chronos-Fit software package (Zuther P. and Lemmer B., Frankfurt, Germany), the parametric indices of the 24 h rest-activity rhythm (MESOR, A, and ϕ) were calculated. Nonparametric indices (IS, IV, L5, mid-phase of L5 (L5t), M10, and mid-phase of M10 (M10t)) were calculated as described in [30,31,35]. In addition, the average weekly motor activity in bed (AciB) and outside of bed (AcoB) was calculated.…”

Section: Wrist Actimetrymentioning

confidence: 99%

“…An important advantage of the method is that it has been used to develop and test a wide range of indicators that have long been actively used in clinical practice [30][31][32]. Wrist actimetry is used to calculate parametric (Midline Estimating Statistic of Rhythm (MESOR), amplitude (A), and acrophase (ϕ) [33,34]) and nonparametric (interdaily stability (IS), intradaily variability (IV), the least active 5 h period (L5) that is nocturnal activity, and the most active 10 h period (M10) that is daily activity [30,31,35]) indices. It is of interest to study the relationship of the indicators of the state of the circadian system and sleep function, assessed by the questionnaire survey method, with the objective indicators obtained by the method of wrist actimetry, which will enable future determination of approaches for a reliable assessment of the contribution of the circadian system misalignment to the development of various pathologies.…”

Section: Introductionmentioning

confidence: 99%

Actimetry-Derived 24 h Rest–Activity Rhythm Indices Applied to Predict MCTQ and PSQI

et al. 2022

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The aim of this study was to identify wrist actimetry-based indices associated with the sleep–wake rhythm characteristics of healthy individuals. The study involved 79 healthy subjects of both sexes (age range 15–62 years (mean: 21.5 ± 9.6 years, women: 77.8%)). Each participant provided personal data, filled out two questionnaires, the Munich ChronoType Questionnaire (MCTQ) and the Pittsburgh Sleep Quality Index (PSQI), and wore a wrist actimeter for a week. A significant positive association of the chronotype with the mid-phase of the most active 10 h period (M10t: B = 0.252, p = 0.015), the mid-phase of the least active 5 h period (L5t: B = 0.338, p = 0.005), and the interdaily stability (IS: B = −0.021, p = 0.017) was noted, as well as the sleep duration with the M10t (B = −0.257, p = 0.003), L5t (B = −0.340, p = 0.001), and IS (B = 0.042, p = 0.003). There was a significant association of social jetlag (B = 0.320, p = 0.032) and sleep quality (B = 0.990, p = 0.013) with motor activity in bed, as well as sleep efficiency with the acrophase (B = −0.043, p = 0.007). Nonparametric indices of the 24 h rest–activity rhythm are useful tools for assessing the sleep–wake rhythm of healthy individuals.

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Circadian ontogeny through the lens of nonparametric variables of actigraphy

Cited by 7 publications

References 35 publications

Disturbances of Continuous Sleep and Circadian Rhythms Account for Behavioral Difficulties in Children with Autism Spectrum Disorder

Disturbances of Continuous Sleep and Circadian Rhythms Account for Behavioral Difficulties in Children with Autism Spectrum Disorder

Disrupted Circadian Rest-Activity Cycles in Inflammatory Bowel Disease Are Associated With Aggressive Disease Phenotype, Subclinical Inflammation, and Dysbiosis

Actimetry-Derived 24 h Rest–Activity Rhythm Indices Applied to Predict MCTQ and PSQI

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