Circadian phase typing in idiopathic generalized epilepsy: Dim light melatonin onset and patterns of melatonin secretion—Semicurve findings in adult patients

Manni, Raffaele; Icco, Roberto De; Cremascoli, Riccardo; Ferrera, Giulia; Furia, Francesca Del; Zambrelli, Elena; Canevini, Maria Paola; Terzaghi, Michele

doi:10.1016/j.yebeh.2016.05.019

Cited by 19 publications

(11 citation statements)

References 22 publications

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“…Proprietary modifications to the commercial assay have resulted in daytime values being recorded consistently around 1 pg/mL. This allows the DLMO to be calculated using a threshold value of 3 pg/mL, for example …”

Section: Melatonin Measurementmentioning

confidence: 88%

“…This allows the DLMO to be calculated using a threshold value of 3 pg/mL, for example. [62][63][64] Stockgrand Ltd. reagents have also been used for saliva melatonin measurement by RIA. Mean daytime levels in pregnant women of between 1.7 and 7.3 pg/mL depending upon the stage of gestation have been reported using this assay (H 3 -melatonin tracer).…”

Section: Saliva Riamentioning

confidence: 99%

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A critical review of melatonin assays: Past and present

Kennaway

2019

Journal of Pineal Research

110

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There has been increased interest in the measurement of melatonin in plasma and saliva recently either as a marker of circadian phase or to understand the physiological role of melatonin. For both situations, there is a need for a specific assay for melatonin that is sensitive enough to detect low concentrations (<2 pg/mL). Since the mid‐1970s, there have been many assays developed to measure melatonin in blood and saliva. Radioimmunoassays and ELISA have predominated because of their relative simplicity and high throughput. In this review, I show that the early radioimmunoassays while providing valuable information about nocturnal melatonin levels in humans, generally produced inaccurate basal (daytime) levels. Mass spectrometry assays, however, have provided us with the target values that immunoassays need to achieve, that is, daytime plasma melatonin levels <1 pg/mL. There are now many contemporary commercial assays available utilising both RIA and ELISA technologies, but not all achieve the standards set by the mass spectrometry assays. The performance of these assays is reviewed. I conclude with recommendations on issues researchers need to consider when conducting melatonin studies, including the importance of time of day of collection, validation of assays, the potential causes of poor assay specificity at low levels, the advantages/disadvantages of using saliva vs plasma and extraction assays vs direct assays, kit manufacturers responsibilities and the reporting requirements when publishing melatonin studies.

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Section: Melatonin Measurementmentioning

confidence: 88%

Section: Saliva Riamentioning

confidence: 99%

A critical review of melatonin assays: Past and present

Kennaway

2019

Journal of Pineal Research

110

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“…Patients with generalized epilepsy show a late circadian phase [133]. The mean Morningness-Eveningness Questionnaire (MEQ) score was reduced in subjects with epilepsy compared to those with focal epilepsy (FE), but was not significantly lower than that in healthy controls.…”

Section: Chronobiology Plays a Role In Epilepsymentioning

confidence: 99%

“…Subjective measures of chronotype do not specify an evening-oriented chronotype in epilepsy. However, data concerning endogenous melatonin secretion suggests that these subjects manifest a late circadian phase [133]. Circadian rhythms of patients admitted for long term EEG and video monitoring, used measurement of the dim light melatonin onset (DLMO).…”

Section: Chronobiology Plays a Role In Epilepsymentioning

confidence: 99%

The role of chronobiology in drug-resistance epilepsy: The potential use of a variability and chronotherapy-based individualized platform for improving the response to anti-seizure drugs

Potruch

Khoury

Ilan

2020

Seizure

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Despite progress in the development of anti-seizure drugs, drug-resistant epilepsy (DRE) occurs in a third of patients. DRE is associated with poor quality of life and increased risk of sudden, unexplained death. The autonomic nervous system and chronobiology play a role in DRE. In the present paper, we provide a narrative review the mechanisms that underlie DRE and characterize some of the autonomic-and chronotherapy-associated parameters that contribute to the degree of response to therapy. Variability describes the functions of many biological systems, which are dynamic and continuously change over time. These systems are required for responses to continuing internal and external triggers, in order to maintain homeostasis and normal function. Both intra-and inter-subject variability in biological systems have been described. We present a platform, which comprises a personalized-based machine learning closed loop algorithm built on epilepsy-related signatures, autonomic signals, and chronotherapy, as a means for overcoming DRE, improving the response, and reducing the toxicity of current therapies.

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“…W innych obserwacjach 160 osobowej grupy, potwierdzono, że chorzy z rozpoznanymi uogólnionymi genetycznie uwarunkowanymi padaczkami, przy niskich wskaźnikach opisanych w kwestionariuszu MEQ częściej wskazują na preferencje tzw. późnych chronotypów w porównaniu do tych z napadami ogniskowymi [54,55].…”

Section: Czy Możemy Mówić O Istnieniu Chronotypów Padaczki Oraz Potrzunclassified

Is epilepsy chronodependent ?

Steinborn¹,

Malendowicz-Major²

2019

Child Neurology

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Napady padaczkowe występują w sposób nawrotowy, w niektórych padaczkach i zespołach padaczkowych nawet cykliczny, uwzględniając rytm okołodobowy, tygodniowy a nawet miesięczny. Celem pracy była analiza danych z piśmiennictwa dotyczącego tzw. chronozależności padaczki i napadów padaczkowych. W dostępnym piśmiennictwie dyskutowany jest problem chronobiologii padaczek oraz jest wiele obserwacji potwierdzających cykliczność napadów padaczkowych w różnych populacjach chorych. Wyodrębnienie tzw. chronotypów padaczek oraz założeń chronofarmakologii wymaga jednak dalszych obserwacji.

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Circadian phase typing in idiopathic generalized epilepsy: Dim light melatonin onset and patterns of melatonin secretion—Semicurve findings in adult patients

Cited by 19 publications

References 22 publications

A critical review of melatonin assays: Past and present

A critical review of melatonin assays: Past and present

The role of chronobiology in drug-resistance epilepsy: The potential use of a variability and chronotherapy-based individualized platform for improving the response to anti-seizure drugs

Is epilepsy chronodependent ?

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