Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA

Koch, Christiane E; Begemann, Kimberly; Kiehn, Jana‐Thabea; Griewahn, L; Mauer, Jan; Hess, Martin W.; Möser, Andreas; Schmid, Sebastian; Oster, Henrik

doi:10.1038/s41467-020-16882-6

Cited by 33 publications

(36 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rhythmic activity and clock gene expression has been demonstrated in brain sites involved in dopamine signalling, including nucleus accumbans (NAc), ventral tegmental area (VTA), and prefrontal cortex (PFC) (Ángeles‐Castellanos et al., 2008; Chung et al., 2014; DePoy et al., 2017; Verwey et al., 2016). Recent work by Koch et al. (2020) demonstrated a role for the VTA in modulating rhythms in hedonic appetite regulation and sensitivity to hyperpalatable food overconsumption.…”

Section: Circadian Clocks and Rhythms In Feeding Behaviourmentioning

confidence: 99%

“…Recent work by Koch et al. (2020) demonstrated a role for the VTA in modulating rhythms in hedonic appetite regulation and sensitivity to hyperpalatable food overconsumption. Although not investigated in the context of food intake, an influential role for REVERBa in regulating dopamine production (via direct regulation of tyrosine hydroxylase, the rate limiting enzyme in dopamine production) in the VTA has been reported (Chung et al., 2014).…”

Section: Circadian Clocks and Rhythms In Feeding Behaviourmentioning

confidence: 99%

“…(2008) demonstrated that distributing the majority of carbohydrate to lunch or breakfast resulted in significantly lower overall daily glycaemic excursions, compared to carbohydrate evenly distributed across the day or majority at dinner. Another intervention comparing the effect of diurnal distribution of carbohydrates and fats, with carbohydrate‐rich meals consumed until 13.30 hr followed by fat‐rich meals consumed between 16.30–22.00 hr (HC/HF), compared to the inverse of this meal sequence (HF/HC), the HF/HC sequence resulted in impaired glycaemic control in participants with impaired glucose tolerance (IGT), but not in normoglycaemic participants (Kessler et al., 2017). The distribution of carbohydrate to the afternoon resulted in significantly higher post‐prandial glucose and insulin peaks in participants with IGT.…”

Section: Effect Of Time Of Day On Post‐prandial Responses and Metabolmentioning

confidence: 99%

See 2 more Smart Citations

Chrono‐nutrition: From molecular and neuronal mechanisms to human epidemiology and timed feeding patterns

Flanagan

Bechtold

Pot

et al. 2020

Journal of Neurochemistry

122

View full text Add to dashboard Cite

The circadian timing system governs daily biological rhythms, synchronising physiology and behaviour to the temporal world. External time cues, including the light‐dark cycle and timing of food intake, provide daily signals for entrainment of the central, master circadian clock in the hypothalamic suprachiasmatic nuclei (SCN), and of metabolic rhythms in peripheral tissues, respectively. Chrono‐nutrition is an emerging field building on the relationship between temporal eating patterns, circadian rhythms, and metabolic health. Evidence from both animal and human research demonstrates adverse metabolic consequences of circadian disruption. Conversely, a growing body of evidence indicates that aligning food intake to periods of the day when circadian rhythms in metabolic processes are optimised for nutrition may be effective for improving metabolic health. Circadian rhythms in glucose and lipid homeostasis, insulin responsiveness and sensitivity, energy expenditure, and postprandial metabolism, may favour eating patterns characterised by earlier temporal distribution of energy. This review details the molecular basis for metabolic clocks, the regulation of feeding behaviour, and the evidence for meal timing as an entraining signal for the circadian system in animal models. The epidemiology of temporal eating patterns in humans is examined, together with evidence from human intervention studies investigating the metabolic effects of morning compared to evening energy intake, and emerging chrono‐nutrition interventions such as time‐restricted feeding. Chrono‐nutrition may have therapeutic application for individuals with and at‐risk of metabolic disease and convey health benefits within the general population.

show abstract

Section: Circadian Clocks and Rhythms In Feeding Behaviourmentioning

confidence: 99%

Section: Circadian Clocks and Rhythms In Feeding Behaviourmentioning

confidence: 99%

Section: Effect Of Time Of Day On Post‐prandial Responses and Metabolmentioning

confidence: 99%

See 1 more Smart Citation

Chrono‐nutrition: From molecular and neuronal mechanisms to human epidemiology and timed feeding patterns

Flanagan

Bechtold

Pot

et al. 2020

Journal of Neurochemistry

122

View full text Add to dashboard Cite

show abstract

“…The circadian system is required to anticipate and adapt physiology to daily recurring changes in the environment over 24 h ( Dibner et al, 2010 ). It coordinates complex behaviors such as sleep ( Collins et al, 2020 ), activity ( Moore and Eichler, 1972 ; Stephan and Zucker, 1972 ), food intake ( Hatori et al, 2012 ; Koch et al, 2020 ), and stress responses ( Oster et al, 2006 ). In mammals, a master circadian pacemaker is located in the hypothalamic suprachiasmatic nucleus (SCN) and subordinated clocks are present throughout the brain and the periphery ( Ralph et al, 1990 ).…”

Section: Introductionmentioning

confidence: 99%

Feto-Maternal Crosstalk in the Development of the Circadian Clock System

Astiz

Oster

2021

Front. Neurosci.

View full text Add to dashboard Cite

The circadian (24 h) clock system adapts physiology and behavior to daily recurring changes in the environment. Compared to the extensive knowledge assembled over the last decades on the circadian system in adults, its regulation and function during development is still largely obscure. It has been shown that environmental factors, such as stress or alterations in photoperiod, disrupt maternal neuroendocrine homeostasis and program the offspring’s circadian function. However, the process of circadian differentiation cannot be fully dependent on maternal rhythms alone, since circadian rhythms in offspring from mothers lacking a functional clock (due to SCN lesioning or genetic clock deletion) develop normally. This mini-review focuses on recent findings suggesting that the embryo/fetal molecular clock machinery is present and functional in several tissues early during gestation. It is entrained by maternal rhythmic signals crossing the placenta while itself controlling responsiveness to such external factors to certain times of the day. The elucidation of the molecular mechanisms through which maternal, placental and embryo/fetal clocks interact with each other, sense, integrate and coordinate signals from the early life environment is improving our understanding of how the circadian system emerges during development and how it affects physiological resilience against external perturbations during this critical time period.

show abstract

“…All protocols recommend at least ten trials per day, but depending on the intertrial interval this leads to differing test durations from 50 min (Shoji et al 2012) to several hours (Deacon 2006). None of the protocols gives instructions with regard to testing time, although day time might influence motivation to gain food (Acosta et al 2020;Koch et al 2020). Thus, with regard to rewarded alternation and position discrimination, there is not one "perfect" test design.…”

Section: Introductionmentioning

confidence: 99%

Alternate without alternative: Neither preference nor simple learning behaviour shown by C57BL/6J mice in the T-maze

Habedank

Kahnau

Lewejohann

2020

Preprint

View full text Add to dashboard Cite

In rodents, the T-maze test is commonly used to investigate spontaneous alternating behaviour but it can also be used to investigate memory, stimuli discrimination or preference between goods. However, especially regarding T-maze preference tests there is no recommended protocol and researchers frequently report reproduction difficulties of this test using mice.Here, we aimed to develop an efficient protocol with female C57BL/6J mice, conducting two preference tests with different design: In a first test, on two consecutive days with five trials, thirteen mice had to choose between two fluids. In a second preference test, on five consecutive days with two (week 1) or three (week 2) trials, twelve mice had to choose between one arm containing bedding mixed with millet and one containing only bedding. This test design resembled a simple learning test (learn where to find the rewarded and the unrewarded arm on the basis of spatial, olfactory and visual cues).In both experiments, mice took only a few seconds per trial to run the maze and make their choice. However, in both experiments mice failed to show any preference for one of the arms. Instead, they alternated choices. We therefore believe the T-maze test to be rather unsuitable to test preference or learning behaviour with C57BL/6J mice.

show abstract

Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA

Cited by 33 publications

References 65 publications

Chrono‐nutrition: From molecular and neuronal mechanisms to human epidemiology and timed feeding patterns

Chrono‐nutrition: From molecular and neuronal mechanisms to human epidemiology and timed feeding patterns

Feto-Maternal Crosstalk in the Development of the Circadian Clock System

Alternate without alternative: Neither preference nor simple learning behaviour shown by C57BL/6J mice in the T-maze

Contact Info

Product

Resources

About