Circadian regulation of human cortical excitability

Ly, Julien; Gaggioni, Giulia; Chellappa, Sarah Laxhmi; Papachilleos, Soterios; Brzozowski, Alexandre; Borsu, Chloé; Rosanova, Mario; Sarasso, Simone; Middleton, Benita; Luxen, André; Archer, Simon N.; Phillips, Christophe; Dijk, Derk Jan; Maquet, Pierre; Massimini, Marcello; Vandewalle, Gilles

doi:10.1038/ncomms11828

Cited by 171 publications

(172 citation statements)

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“…Experimental designs using PSG sleep/wake assessment, cortisol sampling, and next-day measures of neurocognitive functioning (e.g., memory impairment; Keshavan et al, 2010; Li et al, 2016) may also be useful for clarifying risk factors and mediators of relationships between specific sleep/wake disturbances and clinical and functional outcomes in CHR youth. In addition, research has suggested an influence of circadian phase on cortical excitability (i.e., neural reactivity), which in turn impacts cognitive performance (Ly et al, 2016). Cortical excitability, as measured by scalp EEG responses to transcranial magnetic stimulation, may represent another potential mediator of sleep/wake-cognition relationships for future study with CHR adolescents.…”

Section: Discussionmentioning

confidence: 99%

Adolescents at clinical-high risk for psychosis: Circadian rhythm disturbances predict worsened prognosis at 1-year follow-up

Lunsford‐Avery

Gonçalves

Brietzke

et al. 2017

Schizophrenia Research

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Background Individuals with psychotic disorders experience disruptions to both the sleep and circadian components of the sleep/wake cycle. Recent evidence has supported a role of sleep disturbances in emerging psychosis. However, less is known about how circadian rhythm disruptions may relate to psychosis symptoms and prognosis for adolescents with clinical high-risk (CHR) syndromes. The present study examines circadian rest/activity rhythms in CHR and healthy control (HC) youth to clarify the relationships among circadian rhythm disturbance, psychosis symptoms, psychosocial functioning, and the longitudinal course of illness. Methods Thirty-four CHR and 32 HC participants were administered a baseline evaluation, which included clinical interviews, 5 days of actigraphy, and a sleep/activity diary. CHR (n = 29) participants were re-administered clinical interviews at a 1-year follow-up assessment. Results Relative to HC, CHR youth exhibited more fragmented circadian rhythms and later onset of nocturnal rest. Circadian disturbances (fragmented rhythms, low daily activity) were associated with increased psychotic symptom severity among CHR participants at baseline. Circadian disruptions (lower daily activity, rhythms that were more fragmented and/or desynchronized with the light/dark cycle) also predicted severity of psychosis symptoms and psychosocial impairment at 1-year follow-up among CHR youth. Conclusions Circadian rhythm disturbances may represent a potential vulnerability marker for emergence of psychosis, and thus, rest/activity rhythm stabilization has promise to inform early-identification and prevention/intervention strategies for CHR youth. Future studies with longer study designs are necessary to further examine circadian rhythms in the prodromal period and rates of conversion to psychosis among CHR teens.

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Section: Discussionmentioning

confidence: 99%

Adolescents at clinical-high risk for psychosis: Circadian rhythm disturbances predict worsened prognosis at 1-year follow-up

Lunsford‐Avery

Gonçalves

Brietzke

et al. 2017

Schizophrenia Research

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“…Testing after sleep and after sleep deprivation occurred at the same time of day, which is important because cortical excitability changes with time spent awake and with circadian time. Specifically, a recent study measured the amplitude of the TMS-evoked EEG response using a constant routine protocol, which helps unmasking circadian influences [28]. In line with previous sleep deprivation experiments that measured the EEG reaction to TMS [7] or intrinsic measures of cortical excitability [29], it was found that EEG responses were larger at the end as compared to the beginning of 29 hours of continuous wake [28].…”

Section: Introductionmentioning

confidence: 93%

Sleep, synaptic homeostasis and neuronal firing rates

Cirelli

2017

Current Opinion in Neurobiology

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The synaptic homeostasis hypothesis (SHY) states that wake brings about a net overall increase in synaptic strength in many brain circuits that needs to be renormalized by sleep. I will review recent studies that were either specifically designed to test SHY or were interpreted accordingly, including several experiments that focused on changes in neuronal firing rates. I will emphasize that central to SHY is the idea that what is being regulated across the sleep/wake cycle is synaptic strength, not firing rate, and firing rate taken in isolation is not necessarily an adequate proxy for synaptic strength.

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“…All other components, including the P30, did not show significant differences. We only found a non-significant trend for the P30, with a larger amplitude at 1:00PM compared to 10:30AM, which is in line with previous findings of a non-significant increase of P30 amplitude during daytime (Huber et al 2012;Ly et al 2016). The TEP has shown to be reproducible after 1 week ), similar to our observations in three subjects.…”

Section: Discussionsupporting

confidence: 82%

“…This cluster was located left occipitally, just as the two other N100 clusters that turned out to be non-significant after correction. Two earlier reports did not find a significant change of the first large component of the TEP (P30) during daytime (Huber et al 2012;Ly et al 2016). However, these authors did not analyze any other components.…”

Section: Discussionmentioning

confidence: 94%

“…The P30 of the TEP did not differ between 9AM and 3PM, but was significantly higher at 9PM compared to 9AM in five out of six subjects (Huber et al 2012). In a subsequent study by the same research group, the amplitude and slope of the P30 was significantly lower at 9PM compared to 5PM, but no difference was found between 11AM and 5PM (Ly et al 2016). …”

Section: Introductionmentioning

confidence: 90%

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TMS-EEG: first steps towards a clinical application in epilepsy

Braack¹,

Esther²

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1) A parameter that is robust only when using a very strict measuring protocol, cannot be used in clinical practice2) Complete understanding of the TEP is not necessary for clinical utility 3) A silent TMS coil is required for optimal N100/P180 evaluation 4) Defining TMS as a non-invasive technique is inexplicable5) The search for significant differences has nothing to do with clinically relevant findings 6) Progress would be faster if scientists would share more with each other 7) Technology develops faster than our ability to adequately use it 8) There is an important task for the Technical Physician in the medical device industry 9) Life is what happens to us, while we are making other plans (Allen Saunders)Esther ter Braack 6 June 2018 StellingenBehorende bij het proefschrift TMS-EEG: first steps towards a clinical application in epilepsy 1) Een meetrespons die alleen robuust is met een zeer sterk gecontroleerd meetprotocol, is niet bruikbaar in de klinische praktijk 2) Volledig begrip van de TEP is niet vereist voor klinisch gebruik 3) Een stille TMS spoel is nodig voor optimale N100/P180 evaluatie 4) TMS definiëren als een niet-invasieve techniek is niet uit te leggen 5) De zoektocht naar significante verschillen heeft niets te maken met klinisch relevante resultaten 6) De vooruitgang zou sneller gaan als wetenschappers meer met elkaar zouden delen 7) Technologie ontwikkelt zich sneller dan ons vermogen om deze adequaat te gebruiken 8) Er ligt een belangrijke taak voor de Technisch Geneeskundige in de medische technologie industrie 9) Het leven is wat ons overkomt, terwijl we andere plannen maken (Allen Saunders)Esther ter Braack 6 juni 2018 In all patients, evaluation of AED success is based on the absence or recurrence of the seizures, so during this trial and error based process additional seizures may occur. It can take up to several months to either achieve an effective dosage and/or combination of AEDs, meaning that the patient becomes seizure free; or conclude that the patient suffers from refractory epilepsy. Hence, a major challenge is to shorten the time needed to evaluate the success of AEDs on a single subject level. TMS-EEG: FIRST STEPS TOWARDS A CLINICAL APPLICATION IN EPILEPSY ESTHER M. TER BRAACKIn patients with only one seizure, and a normal EEG and MRI, uncertainty remains. A seizure is a traumatic experience, and an epilepsy diagnosis has potential serious consequences, such as the loss of a driving licence or the need for career changes.Currently there is only one option in these patients: wait if a second seizure occurs. The estimated probability of seizure recurrence in patients with a normal EEG is 27.4% (Krumholz et al. 2007). This means that more than a quarter of these patients do have epilepsy, but the definite diagnosis is made only at a later stage. Therefore, another major challenge is to improve the diagnostic process in patients who present with a single seizure and a normal EEG and MRI scan.When we consider these two major challenges, namely improving diagnostics and short...

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Circadian regulation of human cortical excitability

Cited by 171 publications

References 69 publications

Adolescents at clinical-high risk for psychosis: Circadian rhythm disturbances predict worsened prognosis at 1-year follow-up

Adolescents at clinical-high risk for psychosis: Circadian rhythm disturbances predict worsened prognosis at 1-year follow-up

Sleep, synaptic homeostasis and neuronal firing rates

TMS-EEG: first steps towards a clinical application in epilepsy

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