Circadian Regulation of Light-Evoked Attraction and Avoidance Behaviors in Daytime- versus Nighttime-Biting Mosquitoes

Baik, Lisa S.; Nave, Ceazar; Au, David D.; Guda, Tom; Chevez, Joshua A.; Ray, Anandasankar; Holmes, Todd C.

doi:10.1016/j.cub.2020.06.010

Cited by 45 publications

(77 citation statements)

References 49 publications

(88 reference statements)

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“…Night-biting mosquitoes (Anopheles) specifically avoid ultraviolet and blue light during the day. Such behavioral attraction to and avoidance of light in both species change with time of day and show distinct sex and circadian neural circuit differences [ 54 ]. Genetic complexity and ecosystem diversity may cause behavioral changes and resistance in the mosquitoes, contributing to diminished effectiveness of insecticide-treated materials [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Randomized trials of housing interventions to prevent malaria and Aedes-transmitted diseases: A systematic review and meta-analysis

Kua

Lee

2021

PLoS ONE

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Background Mosquito-borne diseases remain a significant public health problem in tropical regions. Housing improvements such as screening of doors and windows may be effective in reducing disease transmission, but the impact remains unclear. Objectives To examine whether housing interventions were effective in reducing mosquito densities in homes and the impact on the incidence of mosquito-borne diseases. Methods In this systematic review and meta-analysis, we searched 16 online databases, including NIH PubMed, CINAHL Complete, LILACS, Ovid MEDLINE, and Cochrane Central Register of Controlled Trials for randomized trials published from database inception to June 30, 2020. The primary outcome was the incidence of any mosquito-borne diseases. Secondary outcomes encompassed entomological indicators of the disease transmission. I2 values were used to explore heterogeneity between studies. A random-effects meta-analysis was used to assess the primary and secondary outcomes, with sub-group analyses for type of interventions on home environment, study settings (rural, urban, or mixed), and overall house type (traditional or modern housing), Results The literature search yielded 4,869 articles. After screening, 18 studies were included in the qualitative review, of which nine were included in the meta-analysis. The studies enrolled 7,200 households in Africa and South America, reporting on malaria or dengue only. The type of home environmental interventions included modification to ceilings and ribbons to close eaves, screening doors and windows with nets, insecticide-treated wall linings in homes, nettings over gables and eaves openings, mosquito trapping systems, metal-roofed houses with mosquito screening, gable windows and closed eaves, and prototype houses using southeast Asian designs. Pooled analysis depicted a lower risk of mosquito-borne diseases in the housing intervention group (OR = 0.68; 95% CI = 0.48 to 0.95; P = 0.03). Subgroup analysis depicted housing intervention reduced the risk of malaria in all settings (OR = 0.63; 95% CI = 0.39 to 1.01; P = 0.05). In urban environment, housing intervention was found to decrease the risk of both malaria and dengue infections (OR = 0.52; 95% CI = 0.27 to 0.99; P = 0.05).Meta-analysis of pooled odds ratio showed a significant benefit of improved housing in reducing indoor vector densities of both Aedes and Anopheles (OR = 0.35; 95% CI = 0.23 to 0.54; P<0.001). Conclusions Housing intervention could reduce transmission of malaria and dengue among people living in the homes. Future research should evaluate the protective effect of specific house features and housing improvements associated with urban development.

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Section: Discussionmentioning

confidence: 99%

Randomized trials of housing interventions to prevent malaria and Aedes-transmitted diseases: A systematic review and meta-analysis

Kua

Lee

2021

PLoS ONE

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“…Understanding how wavelength, intensity, background contrast, range of attraction and light flicker interact with each other would provide a more complete picture of light attraction in biting flies. More research is also needed on aspects of light attraction not discussed in this review, such as light height [ 113 , 114 ], light polarisation [ 115 ], time of day effects [ 40 ] and the presence of reflective surfaces [ 72 ]. Finally, future studies should control for thermal emissions, due to the attractiveness of IR light, as well as intensity, as its effects may not be consistent across wavelengths [ 64 , 76 , 78 ].…”

Section: Discussionmentioning

confidence: 99%

“…Wild-type Drosophila also prefer blue wavelengths over green (565 nm), but inactivating the blue-sensitive Rh5, or removing the UV-sensitive R7 cells, causes flies to prefer green [ 38 ]. The attractiveness of specific wavelength bands can also vary throughout the day and appears to be circadian regulated [ 39 , 40 ]. Wild-type Drosophila show a peak of UV (365 nm) and blue (460 nm) light avoidance behaviour during midday.…”

Section: Physiology Of the Dipteran Eyementioning

confidence: 99%

Artificial light and biting flies: the parallel development of attractive light traps and unattractive domestic lights

et al. 2021

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Light trapping is an important tool for monitoring insect populations. This is especially true for biting Diptera, where light traps play a crucial role in disease surveillance by tracking the presence and abundance of vector species. Physiological and behavioural data have been instrumental in identifying factors that influence dipteran phototaxis and have spurred the development of more effective light traps. However, the development of less attractive domestic lights has received comparatively little interest but could be important for reducing interactions between humans and vector insects, with consequences for reducing disease transmission. Here, we discuss how dipteran eyes respond to light and the factors influencing positive phototaxis, and conclude by identifying key areas for further research. In addition, we include a synthesis of attractive and unattractive wavelengths for a number of vector species. A more comprehensive understanding of how Diptera perceive and respond to light would allow for more efficient vector sampling as well as potentially limiting the risk posed by domestic lighting.

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“…Our detailed whole-brain dynamic PER cycling results predicted all less time resolved ICC results for the 5 × 6 matrix, with a statistical confidence value of 10 −27 ( Roberts et al, 2015 ). Furthermore, LL rapidly induces circadian behavioral rhythmicity ( Pittendrigh and Daan, 1976 ; Baik et al, 2018 , 2020 ). Circadian rhythmicity under an LL entrainment is preserved in mutant flies lacking functional CRY ( Emery et al, 2000 ; Dolezelova et al, 2007 ; Baik et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Weekend Light Shifts Evoke Persistent Drosophila Circadian Neural Network Desynchrony

et al. 2021

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We developed a method for single-cell resolution longitudinal bioluminescence imaging of PERIOD (PER) protein and TIMELESS (TIM) oscillations in cultured male adult Drosophila brains that captures circadian circuit-wide cycling under simulated day/night cycles. Light input analysis confirms that CRYPTOCHROME (CRY) is the primary circadian photoreceptor and mediates clock disruption by constant light (LL), and that eye light input is redundant to CRY; 3-h light phase delays (Friday) followed by 3-h light phase advances (Monday morning) simulate the common practice of staying up later at night on weekends, sleeping in later on weekend days then returning to standard schedule Monday morning [weekend light shift (WLS)]. PER and TIM oscillations are highly synchronous across all major circadian neuronal subgroups in unshifted light schedules for 11 d. In contrast, WLS significantly dampens PER oscillator synchrony and rhythmicity in most circadian neurons during and after exposure. Lateral ventral neuron (LNv) oscillations are the first to desynchronize in WLS and the last to resynchronize in WLS. Surprisingly, the dorsal neuron group-3 (DN3s) increase their within-group synchrony in response to WLS. In vivo , WLS induces transient defects in sleep stability, learning, and memory that temporally coincide with circuit desynchrony. Our findings suggest that WLS schedules disrupt circuit-wide circadian neuronal oscillator synchrony for much of the week, thus leading to observed behavioral defects in sleep, learning, and memory.

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Circadian Regulation of Light-Evoked Attraction and Avoidance Behaviors in Daytime- versus Nighttime-Biting Mosquitoes

Cited by 45 publications

References 49 publications

Randomized trials of housing interventions to prevent malaria and Aedes-transmitted diseases: A systematic review and meta-analysis

Randomized trials of housing interventions to prevent malaria and Aedes-transmitted diseases: A systematic review and meta-analysis

Artificial light and biting flies: the parallel development of attractive light traps and unattractive domestic lights

Weekend Light Shifts Evoke Persistent Drosophila Circadian Neural Network Desynchrony

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